A5059078243- Advanced Drug Delivery Systems
- Oral microbiology and periodontitis research
- Dental Radiography and Imaging
- Salivary Gland Disorders and Functions
- Proteoglycans and glycosaminoglycans research
- Liquid Crystal Research Advancements
- Osteoarthritis Treatment and Mechanisms
- Nanoparticle-Based Drug Delivery
- Drug Solubulity and Delivery Systems
- Ocular Surface and Contact Lens
- Platelet Disorders and Treatments
- Corneal Surgery and Treatments
- Microencapsulation and Drying Processes
- Spectroscopy Techniques in Biomedical and Chemical Research
- RNA Interference and Gene Delivery
- Bioactive Natural Diterpenoids Research
- Plant-based Medicinal Research
- Analytical Chemistry and Chromatography
- Coagulation and Flocculation Studies
- Endodontics and Root Canal Treatments
- Inhalation and Respiratory Drug Delivery
- Spectroscopy and Chemometric Analyses
- Advancements in Transdermal Drug Delivery
- Knee injuries and reconstruction techniques
- Silk-based biomaterials and applications
Sun Yat-sen University
2014-2021
Guangdong University of Technology
2017
Periodontitis is a chronic bacterial infection, and its effective treatment dependent on the retention of antibiotics concentrations at periodontal pockets. In this study, solution–gel based inverse lyotropic liquid crystalline (LLC) system was explored to deliver metronidazole pockets for local periodontitis. It found that metronidazole-loaded LLC precursor spontaneously transformed into gel in presence water oral cavity. The low viscosity would allow penetration rather difficult reach...
This study develops a HA combined lyotropic liquid crystal based spray dressing loaded with pirfenidone for wound healing and scar prophylaxis.
To improve the solubility and bioavailability of oridonin (ORI), glycerol monooleate lipid (GMO)- or phytantriol (PYT)-Poloxamer 407-propylene glycol-water systems were firstly used to develop cubosomes containing ORI for oral delivery. These prepared through fragmentation bulk gels under homogenization conditions 1200 bar nine cycles had a mean particle size around 200 nm with narrow distribution, encapsulation efficiency over 85%. Powder X-ray diffraction differential scanning calorimetry...
The transformation of cubic lyotropic liquid crystals in root canals on coming into contact with water provided long-lasting disinfection against multidrug-resistant bacteria to avoid the endodontic reinfection and follow-up visit.
Phytantriol has received increasing amount of attention in drug delivery system, however, the ability phytantriol based liquid crystal as a novel embolic agent to provide sustained release system is yet be comprehensively demonstrated. The purpose this study was prepare phytantriol-based cubic phase precursor solution loaded with anticancer hydroxycamptothecine (HCPT) and evaluate its embolization properties, vitro cytotoxicity. Phase behavior phytantriol–solvent–water investigated by visual...
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Cubosomes have been presented to enhance dissolution of insoluble drugs, but their applications are limited by the practical hurdles associated with both preparation and storage instability, resulting in drug delivery failure. In present study, an innovative cubosome precursor-microparticles (CPMs) spray dried from aqua-free precursor solution was developed improve stability during as well drugs. These CPMs spontaneously self-assembled situ forming homogeneous dispersion hydration...
Osteoarthritis (OA) is a chronic joint disease with occurrence of articular inflammation and cartilage degeneration. An ideal drug delivery system for effective treatment OA should integrate alleviation protection. Herein, lyotropic liquid crystal (LLC) precursor co-loading hyaluronic acid (HA) celecoxib, formulated as the HLC precursor, was developed combined therapeutic efficacy. The in situ gelling property effectively prolongs retention cavity to achieve long-term anti-inflammation...
Abstract Film coating is an important unit operation to produce solid dosage forms, thereby, the monitoring of this process helpful find problems in time and improve quality coated products. Traditional methods adopted monitor include measurement weight gain, performance disintegration dissolution test, etc. However, not only do these cause destruction samples, but also consume energy. There have recently emerged applications analytical technologies (PAT) on film coating, especially some...