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Wesley Shin

ORCID: 0000-0003-0627-0821
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About
Contact & Profiles
A5006658745
Research Areas
  • Single-cell and spatial transcriptomics
  • Phagocytosis and Immune Regulation
  • FinTech, Crowdfunding, Digital Finance
  • Renal and related cancers
  • Tuberculosis Research and Epidemiology
  • CRISPR and Genetic Engineering
  • Myeloproliferative Neoplasms: Diagnosis and Treatment
  • Epigenetics and DNA Methylation
  • Acute Myeloid Leukemia Research
  • Blood disorders and treatments
  • Microfinance and Financial Inclusion
  • Hemoglobinopathies and Related Disorders

Dana-Farber Cancer Institute
 2021-2024

 Dnmt3a-mutated clonal hematopoiesis promotes osteoporosis
OPENALEX - Publications 
Peter G. Kim Abhishek Niroula Veronica Shkolnik Marie McConkey Amy Lin and 23 more Mikołaj Słabicki John P. Kemp Alexander G. Bick Christopher J. Gibson Gabriel K. Griffin Aswin Sekar Daniel J. Brooks Waihay J. Wong Drew N. Cohen Md Mesbah Uddin Wesley Shin James P. Pirruccello Jonathan M. Tsai Mridul Agrawal Douglas P. Kiel Mary Bouxsein J. Brent Richards David M. Evans Marc N. Wein Julia F. Charles Siddhartha Jaiswal Pradeep Natarajan Benjamin L. Ebert

Osteoporosis is caused by an imbalance of osteoclasts and osteoblasts, occurring in close proximity to hematopoietic cells the bone marrow. Recurrent somatic mutations that lead expanded population mutant blood termed clonal hematopoiesis indeterminate potential (CHIP). Analyzing exome sequencing data from UK Biobank, we found CHIP be associated with increased incident osteoporosis diagnoses decreased mineral density. In murine models, hematopoietic-specific Dnmt3a, most commonly mutated...

10.1084/jem.20211872 article EN cc-by-nc-sa The Journal of Experimental Medicine 2021-10-26
 Loss of Negative Metabolic Feedback Drives TET2 Mutant Inflammation
OPENALEX - Publications 
Geon Kim Christopher A. Hergott Ann K. Miller Amy Deik Meaghan Boileau and 16 more Kevin Bullock Kerry A. Pierce Angelina H. Choy Wesley Shin Marie McConkey Justin CT Loke Birgitta Ryback Michael N. Trinh Justine C. Rutter Hong Yue Paul Park Shourya S. Roy Burman Eric S. Fischer Scott A. Armstrong Clary B. Clish Benjamin L. Ebert

10.1182/blood-2024-208145 article EN Blood 2024-11-05
 The Effect of TET2 Loss on Macrophage Phagocytosis
OPENALEX - Publications 
Ann K. Miller Wesley Shin Marie McConkey Justin CT Loke Geon Kim and 1 more Benjamin L. Ebert

10.1182/blood-2024-208226 article EN Blood 2024-11-05
 In Vivo barcoded CRISPR-Cas9 Screen Identifies Ncoa4-mediated Ferritinophagy As a Dependence in Tet2-Deficient Haemopoiesis
OPENALEX - Publications 
Justin CT Loke Geon Kim Meaghan Boileau Thuy T.P. Nguyen Marie McConkey and 8 more Ann K. Miller Wesley Shin Christopher A. Hergott Maria Ericsson Anja E.H. Nordstrom Scott A. Armstrong Joseph D. Mancias Benjamin L. Ebert

10.1182/blood-2024-200955 article EN Blood 2024-11-05
 In Vivo CRISPR Screening Platform for Studying Myeloid Inflammation and Clonal Dynamics
OPENALEX - Publications 
Peter G. Kim Christopher A. Hergott Justin CT Loke Wesley Shin Marie McConkey and 1 more Benjamin L. Ebert

10.1182/blood-2023-188939 article EN Blood 2023-11-02
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