A5038137284- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Eosinophilic Disorders and Syndromes
- Cardiovascular Effects of Exercise
- Cardiac tumors and thrombi
- Gout, Hyperuricemia, Uric Acid
- Acute Myeloid Leukemia Research
- Epigenetics and DNA Methylation
Dana-Farber Cancer Institute
2021-2024
Harvard University
2024
Osteoporosis is caused by an imbalance of osteoclasts and osteoblasts, occurring in close proximity to hematopoietic cells the bone marrow. Recurrent somatic mutations that lead expanded population mutant blood termed clonal hematopoiesis indeterminate potential (CHIP). Analyzing exome sequencing data from UK Biobank, we found CHIP be associated with increased incident osteoporosis diagnoses decreased mineral density. In murine models, hematopoietic-specific Dnmt3a, most commonly mutated...
Gout is a common inflammatory arthritis caused by precipitation of monosodium urate (MSU) crystals in individuals with hyperuricemia. Acute flares are accompanied secretion proinflammatory cytokines, including interleukin-1β (IL-1β). Clonal hematopoiesis indeterminate potential (CHIP) an age-related condition predisposing to hematologic cancers and cardiovascular disease. CHIP associated elevated IL-1β, thus we investigated as risk factor for gout. To test the clinical association between...
Clonal hematopoiesis of indeterminate potential (CHIP), a common age-associated phenomenon, associates with increased risk both hematological malignancy and cardiovascular disease. Although CHIP is known to increase the myocardial infarction heart failure, influence in cardiac arrhythmias, such as atrial fibrillation (AF), less explored.