A5042348890- Chronic Obstructive Pulmonary Disease (COPD) Research
- Lung Cancer Diagnosis and Treatment
- Respiratory Support and Mechanisms
- Liver Disease Diagnosis and Treatment
- Pleural and Pulmonary Diseases
- Hepatocellular Carcinoma Treatment and Prognosis
- Tracheal and airway disorders
- Pulmonary Hypertension Research and Treatments
- Liver Disease and Transplantation
- MRI in cancer diagnosis
- Metabolism, Diabetes, and Cancer
- Airway Management and Intubation Techniques
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Radiology practices and education
- Radiation Dose and Imaging
- Pancreatic function and diabetes
- Dialysis and Renal Disease Management
- Ultrasound in Clinical Applications
- Appendicitis Diagnosis and Management
- Diabetes Treatment and Management
- Pediatric Urology and Nephrology Studies
- Renal and Vascular Pathologies
- Atomic and Subatomic Physics Research
- Tuberous Sclerosis Complex Research
- Advanced MRI Techniques and Applications
Humboldt-Universität zu Berlin
2019-2021
Charité - Universitätsmedizin Berlin
2015-2021
Freie Universität Berlin
2019-2021
Research Institute of Radiology
2016
University of Tübingen
2010-2011
Purpose: Lung volume reduction using one-way endobronchial valves is a bronchoscopic treatment for patients with severe emphysema without collateral ventilation between the target lobe and ipsilateral lobe(s). CT-scan fissure analysis often used as surrogate to predict absence of ventilation. We aimed evaluate predictive value completeness score (FCS) compared functional Chartis measurement provide cut-off values FCS in patient selection. Patients Methods: Multicenter study eligible valves....
Abstract: The exclusion of collateral ventilation (CV) and other factors affect the clinical success endoscopic lung volume reduction (ELVR). However, despite its benefits, outcome ELVR remains difficult to predict. We investigated whether could be predicted by emphysema distribution assessed computed tomography scan baseline perfusion scintigraphy. Data from 57 patients with no CV in target lobe (TL) were retrospectively analyzed after valves. Pulmonary function tests (PFT), St George’s...
Background High fat diet-induced hyperglycemia and palmitate-stimulated apoptosis was prevented by specific inhibition of protein kinase C delta (PKCδ) in β-cells. To understand the role PKCδ more detail impact changes activity on proliferation survival insulin-secreting cells analyzed under stress-free conditions. Methodology Principal Findings Using genetic pharmacological approaches, effect reduced increased proliferation, cell cycle regulation insulin secreting examined. Proteins were...
Purpose: Quantitative analysis of CT scans has proven to be a reproducible technique, which might help understand the pathophysiology chronic obstructive pulmonary disease (COPD) and combined fibrosis emphysema. The aim this retrospective study was find out if lung function patients with COPD Global Initiative for Chronic Obstructive Lung Disease (GOLD) stages III or IV emphysema is measurably influenced by high attenuation areas as correlate concomitant unspecific fibrotic changes...
Purpose: The aim of this retrospective study was to evaluate correlations between parameters quantitative computed tomography (QCT) analysis, especially the 15th percentile lung attenuation (P15), and clinical tests in a large group patients with pulmonary emphysema. Patients Methods: One hundred seventy-two emphysema chronic obstructive disease (COPD) global initiative for (GOLD) stage 3 or 4 were assessed by nonenhanced thin-section CT scans full inspiratory expiratory breath-hold,...
Background: The degree of interlobar emphysema heterogeneity is thought to play an important role in the outcome endoscopic lung volume reduction (ELVR) therapy patients with advanced COPD. There are multiple ways one could possibly define heterogeneity, and there no standardized definition. Purpose: aim this study was derive a formula for calculating index (HI) when evaluating patient ELVR. Furthermore, attempt made identify threshold relevant regard Patients methods: We retrospectively...
Abstract The aim of this study was to evaluate the risk pneumothorax and need for chest tube insertion in CT-guided lung biopsies identify predictors focusing on pulmonary emphysema determined with quantitative computed tomography. To that end, we retrospectively analysed incidence 371 respect score density mask technique. Other possible impact factors considered were lesion diameter, length biopsy pathway within parenchyma, lobe, needle size, puncture technique, patient positioning...
Abstract Noninvasive early detection of liver cirrhosis and fibrosis is essential for management therapy. The aim was to investigated whether a combination the functional parameter relative enhancement (RE) on Gadoxetic Acid magnetic resonance imaging (Gd-EOB-DTPA-enhanced MRI) T1ρ distinguishes healthy liver. We analyzed patients with Gd-EOB-DTPA-enhanced MRI mapping. Signal intensity measured before after contrast; RE calculated. circular regions interest (T1ρ-cROI). A quotient T1ρ-cROI...
Background Gadolinium ethoxybenzyl diethylenetriaminepentaacetic acid (Gd-EOB-DTPA)-enhanced magnetic resonance imaging (MRI) can be used as an imaging-based liver function test. This study aims to further corroborate its validity. Purpose To compare Gd-EOB-DTPA-enhanced MRI test with the 13 C-methacetin breath Material and Methods Fifty-three patients who underwent T1 relaxometry before 20 min after intravenous Gd-EOB-DTPA administration well a (LiMAx test) were retrospectively analyzed....
Evaluation of emphysema distribution with quantitative computed tomography (qCT) prior to endoscopic lung volume reduction (ELVR) is recommended. The aim this study was determine which the commonly assessed qCT parameters best predicts outcome treatment. 50 patients who underwent technically successful ELVR at our institution were retrospectively analyzed. We performed analysis CT scans obtained and carried out Mann-Whitney U-tests a logistic regression identify that predict in terms...
Purpose To assess the reproducibility of renal resistive index (RRI) in a routine clinical setting. Materials and Methods 22 patients with kidney allograft 19 physicians participated our prospective study. Within 2 hours each patient was examined by 5 different using out 3 different, randomly allocated ultrasound machines. Each investigator determined hilar parenchymal RRI allograft. The limit were assessed as well Cronbach’s alpha intraclass correlation coefficient (ICC). deviation from...
Abstract Objectives To investigate the impact of interventionalist’s experience and gender on radiation dose procedural time in CT-guided interventions. Methods We retrospectively analyzed 4380 interventions performed at our institution with same CT scanner from 2009 until 2018, 1287 (29%) by female 3093 (71%) male interventionalists. Radiation dose, number fluoroscopy images taken per intervention, total time, type degree difficulty were derived saved reports images. All 16...
<b>Background:</b> Selecting severe emphysema patients for endobronchial valve (EBV) treatment can be done using quantitative CT-scan (QCT) fissure analysis to predict the absence of collateral ventilation (CV), or a functional measurement CV Chartis. <b>Objective:</b> To evaluate diagnostic value CT completeness score compared Chartis CV. <b>Methods:</b> Multicenter prospective trial in eligible EBV (Zephyr EBV, PulmonX, USA) treatment. (PulmonX, was used assess status and QCT (FCS,...
It has become clinical routine to assess interlobar collateral ventilation (CV) prior endoscopic lung volume reduction (ELVR), mainly by endobronchial <i>in-vivo</i> measurement (Chartis, Pulmonx Inc., USA) or software based quantitative analyses of fissure integrity (FI) from CT scans (QCT). We asked the question, whether Chartis QCT is better exclude CV. 52 severe COPD patients received assessments in 121 lobes ELVR. In a retrospective analysis, (Thirona, Netherlands) were compared...
Die Protein Kinase C delta (PKCδ) ist ein pro-apoptotisches Enzym, welches für die Fettsäure- und Zytokin-induzierte Apoptose von Insulin-sezernierenden Zellen verantwortlich gemacht wird. Proliferierende INS-1E Zellen, permanent eine PKCδ exprimieren, welche wegen einer Mutation in der ATP-bindenden Domäne keine Kinaseaktivität mehr besitzt, zeigen verzögertes Wachstum. Mit dieser Studie wurde Mechanismus untersucht, über welchen Zellwachstum beeinflusst.
<b>Introduction:</b> Bronchoscopic lung volume reduction using endobronchial valves (EBV) is efficient in severe emphysema when interlobar collateral ventilation (CV) absent or minimal. CV can be assessed directly during bronchoscopy the Chartis system indirectly CT fissure analysis. measurements have been reported to inconclusive 20-30% of cases due dynamic expiratory airway collapse that results a low flow phenotype (LF). It has shown completeness (FC) >95% reflects negativity while FC...