A5083422709- Liver Disease Diagnosis and Treatment
- Cancer Immunotherapy and Biomarkers
- Computational Physics and Python Applications
- Cancer, Stress, Anesthesia, and Immune Response
- Advanced Battery Technologies Research
- Gene Regulatory Network Analysis
- Electric and Hybrid Vehicle Technologies
- Hippo pathway signaling and YAP/TAZ
- Lipid metabolism and biosynthesis
- Cell Image Analysis Techniques
- Advanced Computational Techniques and Applications
- Multilevel Inverters and Converters
- Autophagy in Disease and Therapy
- Energy Harvesting in Wireless Networks
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Advanced Proteomics Techniques and Applications
- Hepatocellular Carcinoma Treatment and Prognosis
- Liver Disease and Transplantation
- Cancer Research and Treatments
- Microbial Metabolic Engineering and Bioproduction
- Eosinophilic Disorders and Syndromes
- Tryptophan and brain disorders
- Renal Transplantation Outcomes and Treatments
- Bioinformatics and Genomic Networks
- Vehicle emissions and performance
Third Affiliated Hospital of Sun Yat-sen University
2020-2025
Sun Yat-sen University
2020-2025
Jinan University
2025
European Bioinformatics Institute
2023-2024
Southwest Petroleum University
2024
State Key Laboratory of Oil and Gas Reservoir Geology and Exploitation
2024
University of Groningen
2019-2023
Xinxiang Medical University
2021-2023
Hebei University of Engineering
2022
Zhejiang University
2018-2021
Many cell biological and biochemical mechanisms controlling the fundamental process of eukaryotic division have been identified; however, temporal dynamics biosynthetic processes during cycle are still elusive. Here, we show that key temporally segregated along cycle. Using budding yeast as a model single-cell methods to dynamically measure metabolic activity, observe two peaks in protein synthesis, G1 S/G2/M phase, whereas lipid polysaccharide synthesis only once, phase. Integrating...
Signaling networks are critical for virtually all cell functions. Our current knowledge of signaling has been summarized in pathway databases, which, while useful, highly biased toward well-studied processes, and do not capture context specific network wiring or cross-talk. Mass spectrometry-based phosphoproteomics data can provide a more unbiased view active processes given context, however, it suffers from low signal-to-noise ratio poor reproducibility across experiments. While progress...
Battery equalizers are widely used in multi-battery systems to maintain balanced charge among individual battery cells. While the research on hardware realization of has received significant attention, rigorous analysis equalization process at system level remains largely unexplored. In this paper, we study three types structures: series-based, layer-based, and module-based. Specifically, derive mathematical models that describe system-level behavior processes under these structures. Then,...
Abstract Background: Hepatic ischemia-reperfusion injury (HIRI) remains a common complication during liver transplantation (LT) in patients. As key downstream effector of the Hippo pathway, Yes-associated protein (YAP) has been reported to be involved various physiological and pathological processes. However, it elusive whether how YAP may control autophagy activation ischemia-reperfusion. Methods: Human tissues from patients who had undergone LT were obtained evaluate correlation between...
To investigate the exposure-response (E-R) relationship, including exposure-efficacy and exposure-safety, of ropeginterferon alfa-2b treatment in patients with polycythaemia vera (PV).
Abstract Protein induced by vitamin K absence or antagonist II (PIVKA-II) plays a critical role in the diagnosis of hepatocellular carcinoma (HCC), however, studies on its efficacy diagnosing recurrent HCC were rarely found. A multicenter, retrospective, and observational study was conducted. During overall follow-up 5 years, patients who had curative resection monitored every 3 months first year post-surgery 6 thereafter if no recurrence occurred. Tumor markers collected at for those with...
We aimed to develop a convenient nomogram predict preoperative MVI in patients with hepatocellular carcinoma (HCC). Patients who underwent surgical resection due HCC from June 2018 2023 at the Third Affiliated Hospital of Sun Yat-sen University were retrospectively reviewed. Univariate and multivariable logistic linear regression analyses used investigate potential risk factors for MVI. A was plotted based on these factors. The tumor diameter (≥ 5 cm), BCLC stage, PLT (>127.50 × 109/L), AST...
ABSTRACT Ropeginterferon alfa‐2b (ropeg) represents a new‐generation interferon‐based therapy approved for polycythaemia vera (PV) treatment. This study aimed to elucidate its population pharmacokinetics‐pharmacodynamics (PopPK‐PD) and exposure‐response (E‐R) relationships. A PopPK model was developed using pooled data from four clinical studies, including two Phase I studies in healthy volunteers ( n = 48) II Chinese or Japanese patients with PV 78). Sequential modeling used analyze (PK‐PD)...
The agricultural sector is the largest source for air pollutants of ammonia (NH3) and greenhouse gases (GHGs) nitrous oxide (N2O) methane (CH4). Establishing a unified homologous emission inventory GHGs essential synergistic abatement pathway studies pollution climate change. However, current agriculture inventories are unclear due to separated classification inconsistent calculating methodologies. This study adopted approach develop NH3, N2O, CH4 from in China 2021, based on crop livestock...
ABSTRACT Hepatic ischemia–reperfusion injury (HIRI) substantially influences the prognosis of liver transplant recipients. Although kynurenic acid (KYNA) has been associated with protective effects against in various organs, precise mechanisms underlying its role HIRI are not well elucidated. In this study, a 70% mouse model and an vitro hypoxia/reoxygenation were employed to examine KYNA on HIRI. we illustrate that methylation status Hippo signalling pathway by enhancing expression fat mass...
Ropeginterferon alfa-2b (Ropeg) is approved for the treatment of adults with polycythemia vera (PV). This report aims to analyze ethnic sensitivity Ropeg PV, comparing pharmacokinetics (PK), efficacy, and safety profiles across diverse groups. We conducted a relevant review PV analysis data obtained from clinical studies involving Ropeg. The PK behavior ropeg showed no significant differences between Chinese overseas populations. Their efficacy were similar analyses indicated that...
Black phosphorus is a promising candidate for future nanoelectronics with moderate electronic band gap and high carrier mobility. Introducing the magnetism into black will widely expand its application scope may present bright prospect in spintronic nanodevices. Here, we report our first-principles calculations of spin-polarized structure monolayer (phosphorene) adsorbed on magnetic europium oxide (EuO) substrate. Effective spin injection phosphorene realized by means interaction nearby...
Intrahepatic cholangiocarcinoma (ICC) is a heterogeneous hepatobiliary tumor with poor prognosis, and it lacks reliable prognostic biomarkers effective therapeutic targets. Long non-coding RNAs (lncRNAs) have been documented to be involved in the progression of various cancers. However, role lncRNAs ICC remains largely unknown. In present work, we used bioinformatics analysis identify differentially expressed human tissues, among which lncRNA-PAICC was found an independent marker ICC....
Abstract Purpose Transjugular intrahepatic portosystemic shunt (TIPS) and splenectomy with periesophagogastric devascularization (SPD) are widely used to treat cirrhotic portal hypertension (PH) prevent variceal rebleeding. However, direct comparisons between these two approaches rare. This study was designed compare the long-term outcomes of TIPS SPD in patients PH Methods The included a history gastroesophageal bleeding 18 80 years age who were admitted Third Affiliated Hospital Sun...
Background Acute rejection (AR) after liver transplantation (LT) remains an important factor affecting the prognosis of patients. CD8 + T cells are considered to be regulatory lymphocytes involved in AR LT. Our previous study confirmed that autophagy mediated by promoting activation and proliferation cells. However, underlying mechanisms regulating during remain unclear. Methods Human biopsy specimens orthotopic LT were collected assess relationship between JNK autophagy. The effect...
Background:: Research has revealed that the expression of PD-L1 is significantly upregulated in tumour cells and binding programmed cell death protein 1 (PD-1) to ligand (PD-L1) inhibits response T cells, thereby suppressing immunity. Therefore, blocking PD-L1/PD-1 signalling become an important target clinical immunotherapy. Some old drugs, namely, non-anticancer have also been found antitumour effects, maprotiline one them. Maprotiline a tetracyclic antidepressant widely used treat...
Abstract For various research questions in metabolism, it is highly desirable to have means available, with which the flux through specific pathways can be perturbed dynamically, a reversible manner, and at timescale that consistent fast turnover rates of metabolism. Optogenetics, principle, offers such possibility. Here, we developed an initial version photo-switchable isocitrate dehydrogenase (IDH) aimed controlling metabolic citric acid cycle budding yeast. By inserting protein-based...
Battery equalizers are widely used in multi-battery systems to maintain balanced charge among individual battery cells. While research on the hardware realization of has received significant attention, rigorous analysis equalization process from system's point view remains largely unexplored. In this paper, we study two types system structures: series connection-based and module-based. Specifically, develop mathematical models that describe system-level behavior processes under these...
Modular multilevel converters (MMC) can be used in many applications such as medium voltage multimegawatt drives and HVDC power transmission. Modulation strategy plays an important role for the good performance of MMC. In this paper, a submodule (SM) regrouping method MMC is presented based on this, sampling time staggered space vector pulse width modulation (STS-SVM) technique proposed Each group has three SMs, which irrespectively from phases. Thus, SVM scheme two-level converter applied...