A5036710783- RNA Research and Splicing
- Acute Myeloid Leukemia Research
- RNA modifications and cancer
- Bladder and Urothelial Cancer Treatments
- Hemoglobinopathies and Related Disorders
- Diabetes and associated disorders
- Thermoregulation and physiological responses
- Electrolyte and hormonal disorders
- Iron Metabolism and Disorders
- Blood groups and transfusion
- Urological Disorders and Treatments
- Pancreatic function and diabetes
- Cell Adhesion Molecules Research
- Ion Transport and Channel Regulation
- Urinary and Genital Oncology Studies
- RNA and protein synthesis mechanisms
- Diet, Metabolism, and Disease
Florida College
1983-2023
University of Florida
1983-2023
Sickle cell disease (SCD) is a diverse group of blood disorders with significant global burden. Contemporary interest in the underlying inflammatory paradigm SCD has emphasized role neutrophil-lymphocyte ratio (NLR) as prognostic marker.We retrospectively reviewed 268 hospitalized patients SCDs different genotypes (HbSS, HbSβ0 thalassemia, HbSβ+ and HbSC), totaling 3329 hospital admissions over 10-year period. Patients were stratified into SS/Sβ0 Sβ+/SC groups for statistical analysis...
Diabetes insipidus is a rarely encountered cause of hypernatremia, often presenting diagnostic and therapeutic dilemma for the encountering physician. Patients are asymptomatic number years due to compensation their polyuria with polydipsia, but may have dramatic presentations in situations where they lose access hydration. Our case 62-year-old woman who was found unconscious signs symptoms heat stroke, later resistant hypernatremia that persisted despite extensive free water...
ABSTRACT Refractory disease is the greatest challenge in acute myeloid leukaemia (AML). Previously, we found vascular-associated AML cells as a source for refractory disease. In this study use bioassay of co-cultured on bone marrow-derived endothelial (BMECs) to screen 31 million compounds within mixture-based synthetic combinatorial library followed by deconvolution leading identification novel polyamine sulfonamide that selectively toxic AML. Using three distinct proteomics methods...
Abstract Refractory and relapsed disease is the greatest challenge in acute myeloid leukemia (AML), we have shown that blood vessels serve as sanctuary sites for AML. Using a high throughput screening assay mimicking AML vascular niche, screened 31 million compounds identified hit compound 2470-51 selectively killed cells CD34+CD38-CD123+ stem cells, while sparing bone marrow-derived endothelial normal hematopoietic progenitor (HSPC) well CD4+ T lymphocytes from healthy volunteers. In vivo...
Refractory and relapsed disease is the greatest challenge in acute myeloid leukemia (AML), we have shown that blood vessels serve as sanctuary sites for AML. Using a high throughput screening assay mimicking AML vascular niche, screened 31 million compounds identified hit compound 2470-51 selectively killed cells CD34+CD38-CD123+ stem cells, while sparing bone marrow-derived endothelial normal hematopoietic progenitor (HSPC) well CD4+ T lymphocytes from healthy volunteers. In vivo...