A5001109063- Acute Myeloid Leukemia Research
- Cutaneous lymphoproliferative disorders research
- Acute Lymphoblastic Leukemia research
- CNS Lymphoma Diagnosis and Treatment
- Lymphoma Diagnosis and Treatment
- Hematopoietic Stem Cell Transplantation
- Cancer Diagnosis and Treatment
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Peptidase Inhibition and Analysis
- Alcoholism and Thiamine Deficiency
- Cancer Immunotherapy and Biomarkers
- Hearing Loss and Rehabilitation
- Urinary and Genital Oncology Studies
- Folate and B Vitamins Research
- Chronic Myeloid Leukemia Treatments
- Ear Surgery and Otitis Media
- Bladder and Urothelial Cancer Treatments
- Fungal Infections and Studies
- Cancer Genomics and Diagnostics
- Gastroesophageal reflux and treatments
- Actinomycetales infections and treatment
- Histiocytic Disorders and Treatments
- Pneumocystis jirovecii pneumonia detection and treatment
- Breast Lesions and Carcinomas
- Male Breast Health Studies
Florida College
2022-2024
University of Florida
2022-2024
UF Health Shands Hospital
2023
University of Florida Health Science Center
2023
University of Florida Health
2023
Sawai ManSingh Medical College and Hospital
2021
Background: Gallbladder carcinoma (GBC) is a rare, aggressive malignancy comprising 0.5% of gastrointestinal cancers. It has poor survival outcomes due to its insidious onset, lack standardized screening, and limited therapies. Advanced-stage diagnosis with liver, lymph node, peritoneal metastasis common, while bone rare. The knowledge on in GBC case reports small series, clinical significance largely unexplored. Methods: study extracted the demographic variables patients metastatic (M1)...
Background: Acute erythroid leukemia (AEL), also known as pure leukemia, is a rare subtype of acute myeloid (AML) characterized by the proliferation malignant precursors. Outcome data at population level are scarce. Methods: We performed retrospective analysis Surveillance Epidemiology and End Results (SEER) database. All cases with histologically confirmed diagnosis (pure) during period 2000–2019 were included in study. The Kaplan–Meier method was used to perform survival analysis....
A phase 1b study was conducted to evaluate the safety and feasibility of ciprofloxacin etoposide combination treatment in subjects with relapsed refractory acute myeloid leukemia. Eleven were enrolled study. Utilizing standard '3 + 3' design, escalating doses (750 mg, 1000 mg) twice daily on D1-D10 a fixed dose (200 D2-D8 administered. Maximum tolerated determined be mg 200 etoposide. Serious adverse events occurred 54.5% (
Abstract Myelodysplastic neoplasms (MDS) define clonal hematopoietic malignancies characterized by heterogeneous mutational and clinical spectra typically seen in the elderly. Curative treatment entails allogeneic stem cell transplant, which is often not a feasible option due to older age significant comorbidities. Immunotherapy has cytotoxic capacity elicit tumor-specific killing with long-term immunological memory. While number of platforms have emerged, therapeutic vaccination presents as...
Background: There is paucity of data on the spectrum breast diseases in India due to lack reporting system. This study was conducted understand pattern northwest India. It by far largest provide epidemiological disease Methods: Total 8604 pathological reports were obtained from four major diagnostic centers North West These included benign and malignant lesions. Results: 5985 (69.56%) lesions group 2619 (30.43%) group. Women formed 92.73% (7978) Among lesions, most common discrete lumps...
In 2021, the FDA approved combination of pembrolizumab with platinum and fluoropyrimidine-based chemotherapy for advanced esophageal gastroesophageal junction (GEJ) cancers, regardless PD-L1 score. Pembrolizumab alone may benefit MSI-H adenocarcinomas, but most patients pMMR/MSS types require it in standard chemotherapy. The NCCN recognizes predictive value CPS recommends plus ≥10. Undifferentiated carcinoma esophagus, a rare cancer subtype poor prognosis, still lacks well-defined optimal...
e19031 Background: Acute Erythroid Leukemia (AEL), also known as pure erythroid leukemia, is a rare subtype of Myeloid (AML) characterized by proliferation malignant precursors. It can occur at any age and portends aggressive course with dismal outcomes. Treatment consists high-intensity chemotherapy allogeneic hematopoietic stem cell transplant. Outcome data population level scarce. Methods: We performed retrospective analysis the Surveillance Epidemiology End Results (SEER) database, U.S....
e19053 Background: Recent advances and approval of multiple targeted non-targeted agents have significantly transformed care for Acute Myeloid Leukemia (AML) over the past 5 years, particularly older/unfit patients. While this has provided clinicians with several treatment options in both upfront relapsed/refractory setting, it also increased complexity clinical decision making. Although trials shown immense promise these therapies, real-world outcomes not been reported. The primary aim...
Introduction: In 2017, the FDA granted an accelerated approval for pembrolizumab (anti PD-1) patients with unresectable or metastatic tumors demonstrating dMMR/MSI-H, irrespective of primary site, as second-line later treatment. March 2023, converted it to full approval. Although a single agent may offer benefits approximately 10%-20% gastroesophageal adenocarcinoma cases that are MSI-H, majority pMMR/MSS. For these patients, immune checkpoint inhibitors (ICIs), including pembrolizumab,...
Introduction: Achalasia is primarily a motility disorder of the esophagus driven by aberrant peristalsis and failure sphincter relaxation. Per review current literature regarding achalasia, patients present with dysphagia, usually to solids and, if progressed, liquids. Seldomly, untreated achalasia results in thiamine deficiency presents as Wernicke’s-Korsakoff (WK). This acute neurologic condition affects central peripheral nervous system known triad ataxia, ophthalmoplegia confusion....
Introduction: With the increasing incidence of advanced stage gallbladder adenocarcinoma, several studies have been conducted to understand management and outcomes. However, there is paucity data on site-specific metastasis. Bone a rare site metastasis in adenocarcinoma prognostic significance this manifestation unclear. Methods: We performed retrospective analysis Surveillance Epidemiology End Results (SEER) database, U.S. population-based registry maintained by National Cancer Institute....
Abstract Background B-Acute Lymphoblastic Leukemia can rarely present with extramedullary involvement to non-CNS/testicular sites. Extramedullary relapse of B-ALL after allogeneic hematopoietic stem cell transplant is not well described in the literature and has shown demonstrate different clinical course than medullary relapse. Case presentation A 35-year-old female a history BCR-ABL negative presented recurrent unusual leukemic infiltration bone, genital tract, gastrointestinal tract...
•We report a case of brain abscess caused by Nocardia farcinica.•The patient had completed chemotherapy for diffuse large B cell lymphoma 2 months before infection.•Initial imaging was unable to differentiate infection vs disease recurrence.•Biopsy and diagnosis were delayed the patient's comorbidities goals care.•Clinical suspicion merits expeditious diagnostic evaluation. A 78-year-old female with history (DLBCL) admitted fatigue, lower extremity weakness, vision changes. Magnetic...
Abstract Introduction: Neurolymphomatosis (NL) is an extremely rare manifestation of lymphoproliferative and hematologic malignancies characterized by direct neoplastic infiltration the peripheral nervous system, ubiquitously portends poor outcomes with dismal survival. This challenging infrequent clinical entity most commonly associated B-cell non-Hodgkin lymphomas (NHLs), only a few cases NL as presentation mantle cell lymphoma (MCL) ever reported. The heterogenous features overlap several...