A5052842311- Renal Transplantation Outcomes and Treatments
- Polyomavirus and related diseases
- Renal Diseases and Glomerulopathies
- Organ Transplantation Techniques and Outcomes
- Pharmacological Effects and Toxicity Studies
- Renal and Vascular Pathologies
- Organ and Tissue Transplantation Research
- Parathyroid Disorders and Treatments
- Central European Literary Studies
- Neurological Complications and Syndromes
- Polish Historical and Cultural Studies
- Language and Culture
- Dialysis and Renal Disease Management
- Liver Disease and Transplantation
- Transplantation: Methods and Outcomes
- Pediatric Urology and Nephrology Studies
- Organ Donation and Transplantation
- Bone health and treatments
- Renal cell carcinoma treatment
- German Literature and Culture Studies
- Parvovirus B19 Infection Studies
- Erythropoietin and Anemia Treatment
- Bone and Joint Diseases
- Amyloidosis: Diagnosis, Treatment, Outcomes
- Urticaria and Related Conditions
University Hospital Olomouc
2012-2023
Palacký University Olomouc
1999-2023
Center for Rheumatology
2016
University of Vienna
2014
Ocní klinika
2002-2010
Ageing goes hand in with altered DNA repair and defence mechanisms against damage. To improve the body's overall resistance chromosomal damage, maintaining a healthy active lifestyle is of great concern, especially elderly. As more people are getting older, they change from home living to an institutionalised situation, which often accompanied by malnutrition, depression inactivity. So far, there lack data on damage relation age fitness status. The aim this study was examine effect aerobic...
Aims: To provide the first single-center study of a Czech renal transplant program that compares skin cancer risk estimates to general population. Methods: We studied total 603 patients undergoing transplantation at University Hospital Olomouc Transplant Center between January 1984 and December 2009. The mean time follow-up was 5.5 years. Three were excluded for diagnosis before transplant. cohort linked with National Cancer Registry Republic. For non-melanoma (NMSC), observed number cancers...
Background: Merkel cell carcinoma (MCC) is a rare tumour of the skin that predominantly affects elderly or immunocompromised patients. The malignant transformation cells currently considered to be related an infection with polyomavirus. Case Report: We present case 62-year-old man who developed polyomavirus-positive MCC in non-UV-exposed part right gluteal region 8 years after combined kidney-pancreas transplantation. Following excision and radical re-excision tumour, no adjuvant...
We hypothesized that nucleic acids, free and/or complexed, filtered locally released, might be entrapped in the kidneys because of specific acid binding microbial pattern recognizing Toll-like receptors (TLRs). This hypothesis potential was tested using paraffin sections from healthy control, SLE and transplant kidneys, which were labelled TLR-specific rabbit or goat anti–human antibodies immunoperoxidase staining. Normal contain some double- (TLR-3) single-stranded RNA (TLR-8) receptors,...
Aims: Restoration of renal function after kidney transplantation (KT) is expected to improve oxidative stress (OS). However, little known about the influence calcineurin inhibitors on oxidized low-density lipoproteins (ox-LDL) KT. The aim this study was evaluate ox-LDLs and related markers OS, advanced oxidation protein products (AOPP) total antioxidant status (TAS) in patients KT either cyclosporin A (CyA) or tacrolimus (Tac) treatment. Methods: This a prospective, randomized, single-center...
SLE is characterized by overproduction of various types autoantibodies. Under certain circumstances, antibodies targeting some the neoepitopes complement system can be seen. The most studied among directed against a component anti-C1q. Anti-C1q are present in approximately one third patients with lupus, who often have high clinical disease activity and particular renal involvement. In presence titers anti-C1q also levels C1q C3 C4 components usually low. not limited or specific just for...
From 1995 to 2002 we monitored a group of 127 patients who had undergone kidney transplantations in the Olomouc transplantation centre. The aim our study was assess function kidneys after transplantation, which were rinsed during removal from cadaverous donors and afterwards treated by different preservative dilutions. We divided into three groups approximate similar size, according used dilution - EC (Eurocollins), HTK (Custodiol) UW (Viaspan). In first weeks assessed each group, immediate...
Background. Thrombotic microangiopathy (TMA) significantly affects kidney graft survival, but its pathophysiology remains poorly understood. Methods. In this multicenter, retrospective, case–control paired study designed to control for donor-associated risks, we assessed the recipients’ risk factors de novo TMA development and effects on survival. The group consists of patients with found in case biopsies from 2000 2019 (n = 93), recipients grafts 93). Graft follow-up was initiated at time...
The most serious complication of renal biopsy is vascular damage with subsequent haemorrhage. To our knowledge, we present a first ever case lumbar artery (LA) rupture accompanied by massive retroperitoneal bleeding, which developed after significant amount time following the itself. In 63-year-old Caucasian female patient, percutaneous left kidney was performed under continuous ultrasound guidance. On fourteenth day procedure, she examined for sudden onset region pain. Computed tomography...
Tacrolimus and Cyclosporine A (CyA) are cornerstones in immunosuppressive therapy. side eff ects include hypertension hypercholesterolemia both of which may increase the risk cardiovascular mortality, gingival hyperplasia hirsutism known to reduce quality life. The aim this prospective study was evaluate changes profile cosmetic after conversion from CyA tacrolimus.25 stable kidney transplant recipients (9 male, 16 female) were converted a tacrolimus--based regimen. Mean age 45.7 +/- 13.5...
The CONCERTO study results showing the beneficial effects of conversion from cyclosporine to tacrolimus prolonged-release (tacrolimus PR) in stabilised patients after kidney transplantation, were first published 2011. This communication describes our experience PR transplant patients. aim was determine whether it could be used routine clinical practice Czech and Slovak Republics.Evaluation carried out at five transplantation centres Republic Slovakia. In all participating Centres, drug...