Construction of contiguous all-carbon quaternary stereogenic centers is a long-standing challenge in synthetic organic chemistry. In this report, phosphine-catalyzed enantioselective (3+2) annulation reaction between allenes and isoindigos, containing either two identical or different oxindole moieties, introduced as powerful strategy for the construction spirocyclic bisindoline alkaloid core structures. The reported reactions feature high chemical yields, excellent enantioselectivities,...

The available methods of chemical synthesis have arguably contributed to the prevalence aromatic rings, such as benzene, toluene, xylene, or pyridine, in modern pharmaceuticals. Many sp

A phosphine-catalyzed highly enantioselective and diastereoselective (up to 98 % ee >20 : 1 dr) (3+2) annulation between vinylcyclopropanes N-tosylaldimines has been developed, which allows facile access a range of functionalized chiral pyrrolidines. Notably, this method makes use as synthon for phosphine-mediated asymmetric reaction, will offer new opportunities potential applications cyclopropanes substrates in organic transformations.

The highly enantioselective and complete hydrogenation of protected indoles benzofurans has been developed, affording facile access to a range chiral three-dimensional octahydroindoles octahydrobenzofurans, which are prevalent in many bioactive molecules organocatalysts. Remarkably, we control the nature ruthenium N-heterocyclic carbene complex employed as both homogeneous heterogeneous catalysts, providing new avenues for its potential applications asymmetric more challenging aromatic compounds.

The incorporation of three-dimensional structures into drug molecules has demonstrated significant improvements in clinical success. Late-stage saturation provides a direct pathway for this transformation. However, achieving selective and controllable reduction aromatic rings remains challenging, particularly when multiple coexist. Herein, we present the switchable chemoselective hydrogenation benzene pyridine rings. utility protocol been comprehensively investigated diversified substrates...

We introduced a type of allenic ketone as dielectrophilic C4 synthon in phosphine-mediated reactions. The high electrophilicity the advanced intermediates created upon phosphine activation empowered utilization 3,3′-bis-oxindoles two-carbon reaction partner highly enantioselective [4 + 2] annulation, allowing for facile creation spirocyclic bisindoline structures containing two contiguous quaternary stereogenic centers. Synthetic manipulations annulation product led to concise total...

Abstract A sequential phosphine‐catalyzed asymmetric [3+2] annulation of aldimines with allenoates and oxidative central‐to‐axial chirality transfer strategy has been developed. This approach is operationally simple, allowing for rapid access to a range axially chiral CF 3 ‐containing 2‐arylpyrroles high enantiomeric excess. Furthermore, an atroposelective synthesis esaxerenone presented, illustrating the practical potential reported method.

Bicyclo[1.1.0]butanes (BCBs) have recently garnered significant research interest as versatile precursors for synthesizing potential [n.1.1] bioisosteres and multi-functionalized cyclobutanes in a straightforward atom-economical manner. Here, we report solvent-dependent divergent cyclization of BCBs that provides highly diastereospecific decorated oxygen-containing bicyclo[3.1.1]heptanes (BCHeps), which serve meta-substituted arenes. Additionally, an unprecedented 1,2-difunctionalization...

Abstract Construction of contiguous all‐carbon quaternary stereogenic centers is a long‐standing challenge in synthetic organic chemistry. In this report, phosphine‐catalyzed enantioselective (3+2) annulation reaction between allenes and isoindigos, containing either two identical or different oxindole moieties, introduced as powerful strategy for the construction spirocyclic bisindoline alkaloid core structures. The reported reactions feature high chemical yields, excellent...

A phosphine-catalyzed highly enantioselective and diastereoselective (up to 98 % ee >20 : 1 dr) (3+2) annulation between vinylcyclopropanes N-tosylaldimines has been developed, which allows facile access a range of functionalized chiral pyrrolidines. Notably, this method makes use as synthon for phosphine-mediated asymmetric reaction, will offer new opportunities potential applications cyclopropanes substrates in organic transformations.

Abstract Prostaglandins are among the most significant natural isolates owing to their broad range of bioactivities and unique structures. However, current synthesis prostaglandins still suffers from low yields lengthy steps. Here, We reported a practicability-oriented synthetic strategy for enantioselective divergent PGs. In this approach, multiply substituted five-membered rings in were constructed via key Zhang enyne cycloisomerization with excellent selectivity (> 20:1 dr, 98% ee)....

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Abstract Bicyclo[1.1.0]butane (BCBs) haben in jüngster Zeit als vielseitige Vorstufen für die unkomplizierte und atomökonomische Synthese potenzieller [n.1.1]‐Bioisostere multifunktionalisierter Cyclobutane großes Forschungsinteresse geweckt. Hier berichten wir über eine lösungsmittelabhängige divergente Cyclisierung von BCBs, hochgradig diastereospezifisch dekorierte sauerstoffhaltige Bicyclo[3.1.1]heptane (BCHeps) liefert, Bioisostere meta‐substituierten Arenen dienen. Zusätzlich wurde ein...

Abstract A sequential phosphine‐catalyzed asymmetric [3+2] annulation of aldimines with allenoates and oxidative central‐to‐axial chirality transfer strategy has been developed. This approach is operationally simple, allowing for rapid access to a range axially chiral CF 3 ‐containing 2‐arylpyrroles high enantiomeric excess. Furthermore, an atroposelective synthesis esaxerenone presented, illustrating the practical potential reported method.

Anisotropic etching and conversion of MOF micro/nanostructures results in innovative structures regulates properties. However, the anisotropic higher-order construction MOFs remains a major challenge. Here, for first time, we report preparation two unprecedented Bi-MOF (CAU-17) derivative via facile chemical simultaneous on solid CAU-17 microrods by reaction with Te- Se-containing oxyanions. The TeOx2--mediated hollow tubular are obtained unique splitting, self-welding, dissolution...

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The extraction of long-lived radionuclides from nuclear glass waste (NGW) is a prerequisite for transmutation and resource recovery. However, this remains great challenge due to the recognized extreme chemical stability NGW. Here, we demonstrate first time an ultrasound-assisted wet dissolution method efficient elution Most elements, including major constituents radionuclides, were significantly leached out NGW in 1 mL H2O2/2 M HCl solution within h at 35 oC 270 W ultrasound, which much...