A5102981949- Sepsis Diagnosis and Treatment
- Pharmaceutical Practices and Patient Outcomes
- Patient Safety and Medication Errors
- Intensive Care Unit Cognitive Disorders
- Congenital Heart Disease Studies
- Hemodynamic Monitoring and Therapy
- Cardiac, Anesthesia and Surgical Outcomes
- Respiratory Support and Mechanisms
- RNA Interference and Gene Delivery
- Infective Endocarditis Diagnosis and Management
- Neonatal Respiratory Health Research
- Extracellular vesicles in disease
- Neuroinflammation and Neurodegeneration Mechanisms
- Pulmonary Hypertension Research and Treatments
- Renin-Angiotensin System Studies
- MicroRNA in disease regulation
- Cardiac Arrest and Resuscitation
- Antimicrobial Resistance in Staphylococcus
- Renal function and acid-base balance
- S100 Proteins and Annexins
- Thermoregulation and physiological responses
- Obstructive Sleep Apnea Research
- Clinical Reasoning and Diagnostic Skills
- Pericarditis and Cardiac Tamponade
- Neuropeptides and Animal Physiology
University of Georgia
2019-2024
Charlie Norwood VA Medical Center
2021-2024
Georgia College & State University
2019-2024
Augusta University
2019-2023
Augusta University Health
2020-2023
Orlando Health
2019-2022
Anna Needs Neuroblastoma Answers
2020
American Association of Colleges of Pharmacy
2019
The enormous library of pharmaceutical compounds presents endless research avenues. However, several factors limit the therapeutic potential these drugs, such as drug resistance, stability, off-target toxicity, and inadequate delivery to site action. Extracellular vesicles (EVs) are lipid bilayer-delimited particles naturally released from cells. Growing evidence shows that EVs have great serve effective carriers. Since can not only transfer biological information, but also effectively...
Abstract Introduction Pharmacists are widely recognized members of the critical care health team. However, unlike other professions, pharmacists do not have standardized pharmacist to patient ratios that establish maximal cost‐efficiency while maintaining optimal safety. Though many prior recommendations claim a ratio 1:15 for safe pharmacy practice, ranged as low 1:8 high 1:30. Objectives To determine pharmacists' perceptions within intensive unit (ICU) and qualitatively quantitatively...
Abstract Background Clinical pharmacists are established members of the interprofessional patient care team, but limited guidance for optimal utilization pharmacy resources is available. Objective measurement medication regimen complexity offers a novel process evaluating pharmacist activity. The purpose this study was to evaluate relationship between complexity, as measured by scoring tool (MRC‐ICU), and both interventions drug‐drug interactions (DDIs). Methods This multi‐center,...
Abstract Background The MRC-ICU, a novel regimen complexity scoring tool, provides an objective measure of medication in critically ill patients. MRC-ICU may have the ability to evaluate impact critical care pharmacists on patient outcomes but requires further validation. this study was confirm external validity tool at multiple institutions and intensive unit (ICU) settings. Methods This multicenter, prospective, observational study. electronic medical record reviewed collect demographics...
Providing analgesia and sedation is an essential component of caring for many mechanically ventilated patients. The selection analgesic sedative medications during the COVID-19 pandemic, impact these practices on patient outcomes, remain incompletely characterized.
De-resuscitation practices in septic patients with heart failure (HF) are not well characterized. This study aimed to determine if diuretic initiation within 48 hours of intensive care unit (ICU) admission was associated a positive fluid balance and patient outcomes.This single-center, retrospective cohort included adult an established diagnosis HF admitted the ICU sepsis or shock. The primary outcome incidence receiving early (<48 hours) versus late (>48 diuresis. Secondary outcomes...
Acute respiratory distress syndrome (ARDS) confers high morbidity and mortality, with a death rate reaching 40%. Pre-clinical clinical studies have cited sex-specific sex hormones as critical contributor to divergent immunologic responses. Therefore, exploration of hormone roles following lung injury ARDS development is needed. Tissue inhibitor metalloproteinase-1 (TIMP-1) was the first-discovered natural collagenase located exclusively on X chromosome. This study aimed evaluate prognostic...
Sustained microglial activation contributes to the development of post-stroke cognitive impairment (PSCI). Compound 21 (C21), an angiotensin II type 2 receptor agonist, has shown some neurovascular protection after stroke. This study aimed investigate direct anti-inflammatory effects C21 on macrophages, as well brain innate immune cells.Murine cell line (C8-B4) and RAW 264.7 macrophages were exposed lipopolysaccharide (LPS) co-treated with C21. Pro-inflammatory mediators assessed via RT-qPCR...
Purpose: Critical care pharmacists are considered essential members of the healthcare team; however, justification and recruitment new positions, especially in evening or weekend shifts, remains a significant challenge. The purpose this study was to investigate number interventions, type associated cost savings with addition 1 board certified critical clinical pharmacist shift. Methods: This prospective collection characterization shift pharmacist’s interventions over 12-week period....
<p dir="ltr">Objective</p><p dir="ltr">To determine the efficacy of advanced hybrid closed loop (AHCL) therapy in a high-risk cohort youth on continuous subcutaneous insulin infusion (CSII)+/-continuous glucose monitoring (CGM) with suboptimal glycemia. </p><p dir="ltr">Research Design and Methods</p><p dir="ltr">In 6-month multicentre clinical trial, type 1 diabetes mean most recent HbA1c > 8.5%(65mmol/mol) were randomly assigned 1:1 to AHCL or...
The optimal vasopressor management for septic patients with left ventricular (LV) dysfunction has not been well established, and current evidence is conflicting regarding the discontinuation order.The objective was to evaluate impact of LV on hemodynamic shock by assessing incidence clinically significant hypotension after discontinuation.In this single-center, retrospective cohort study, adult were included if they met Sepsis-3 definition shock, had (defined as an ejection fraction ≤40%),...