A5077446908- Parkinson's Disease Mechanisms and Treatments
- Retinal Development and Disorders
- Nerve injury and regeneration
- Cholinesterase and Neurodegenerative Diseases
- Coenzyme Q10 studies and effects
- Alzheimer's disease research and treatments
- Pluripotent Stem Cells Research
- Autophagy in Disease and Therapy
- Lysosomal Storage Disorders Research
- Nuclear Receptors and Signaling
- Genomics, phytochemicals, and oxidative stress
Chang Gung University
2016-2020
Chang Gung Memorial Hospital
2020
Linkou Chang Gung Memorial Hospital
2016-2019
Alzheimer's disease (AD), probably caused by abnormal accumulation of β-amyloid (Aβ) and aberrant phosphorylation tau, is the most common cause dementia among older people. Generation patient-specific neurons induced pluripotent stem cell (iPSC) technology facilitates exploration features in live human from AD patients. In this study, we generated iPSCs two familial patients carrying a heterozygous D678H mutation APP gene (AD-iPSCs). The derived our AD-iPSCs demonstrated intracellular...
Parkinson's disease (PD) is a common neurodegenerative characterized by progressive loss of dopaminergic (DAergic) neurons in ventral brain. A disaccharide trehalose has demonstrated the potential to mitigate DAergic models for PD. However, rapidly hydrolyzed into glucose trehalase intestine, limiting its clinical practice. Here we investigated neuroprotective potentials two trehalase-indigestible analogs, lactulose and melibiose, sub-chronic 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine...
Parkinson's disease (PD) is a common neurodegenerative accompanied by loss of dopaminergic (DAergic) neurons. The development therapies to prevent progression the main goal drug discovery. There increasing evidence that oxidative stress and antioxidants may contribute pathogenesis treatment PD, respectively. In present study, we investigated antioxidative protective effects indole-derivative compound NC001-8 in DAergic neurons derived from SH-SY5Y cells PD-specific induced pluripotent stem...