A5009936831- Neuroendocrine regulation and behavior
- Stress Responses and Cortisol
- Heat shock proteins research
- Pluripotent Stem Cells Research
- Receptor Mechanisms and Signaling
- Neurotransmitter Receptor Influence on Behavior
- CRISPR and Genetic Engineering
- Evolutionary Game Theory and Cooperation
- Neuropeptides and Animal Physiology
- Tryptophan and brain disorders
- Epigenetics and DNA Methylation
- Treatment of Major Depression
- Virus-based gene therapy research
- Evolutionary Psychology and Human Behavior
- Tissue Engineering and Regenerative Medicine
- Endoplasmic Reticulum Stress and Disease
- Olfactory and Sensory Function Studies
- Toxin Mechanisms and Immunotoxins
- Cancer-related Molecular Pathways
- Primate Behavior and Ecology
- FOXO transcription factor regulation
- Advanced Thermodynamic Systems and Engines
- Ubiquitin and proteasome pathways
- DNA Repair Mechanisms
- interferon and immune responses
Polish Academy of Sciences
2020-2023
Maj Institute of Pharmacology
2020-2023
International Institute of Molecular and Cell Biology
2015-2021
Postgraduate School of Molecular Medicine
2016-2019
Medical University of Warsaw
2016-2019
Greater Poland Cancer Center
2016-2017
Poznan University of Medical Sciences
2013
Utilizing The Cancer Genome Atlas (TCGA) and KM plotter databases we identified six heat shock proteins associated with survival of breast cancer patients. curves samples high low expression genes were compared by log-rank test (Mantel-Haenszel). Interestingly, patients overexpressing two HSPs - HSPA2 DNAJC20 exhibited longer survival, whereas overexpression other four HSP90AA1, CCT1, CCT2, CCT6A resulted in unfavorable prognosis for We explored correlations between level clinicopathological...
// Patrycja Czerwińska 1, 2, 3 , Parantu K. Shah 4 Katarzyna Tomczak Marta Klimczak Sylwia Mazurek Barbara Sozańska 5 Przemysław Biecek 5, 6 Konstanty Korski 7 Violetta Filas Andrzej Mackiewicz 2 Jannik N. Andersen Maciej Wiznerowicz 1 Laboratory for Gene Therapy, Department of Diagnostics and Cancer Immunology, Greater Poland Centre, Poznan, Chair Medical Biotechnology, Poznan University Sciences, Postgraduate School Molecular Medicine, Warsaw, Institute Applied Science, Texas MD Anderson...
Utilizing the TCGA PANCAN12 dataset we discovered that cancer patients with mutations in TP53 tumor suppressor and overexpression of MDM2 oncogene exhibited decreased survival post treatment. Interestingly, case breast patients, this phenomenon correlated high expression level several molecular chaperones belonging to HSPA, DNAJB HSPC families. To verify hypothesis such a genetic background may promote chaperone-mediated chemoresistance, employed lung cell lines constitutively overexpressed...
Abstract Prosocial behavior, defined as voluntary behavior intended to benefit another, has long been regarded a primarily human characteristic. In recent years, it was reported that laboratory animals also favor prosocial choices in various experimental paradigms, thus demonstrating behaviors are evolutionarily conserved. Here, we investigated adult male and female C57BL/6 mice task where subject mouse equally rewarded for entering any of the two compartments cage, but only compartment...
Cellular reprogramming proceeds in a stepwise pathway initiated by binding and transcription of pluripotency factors followed genome-wide epigenetic changes. Priming events, such as erasure DNA methylation chromatin remodeling determines the success acquisition later. Therefore, growing efforts are made to understand regulatory network that makes possible efficient. Here, we analyze role transcriptional corepressor TRIM28, involved heterochromatin formation, during process mouse somatic...
Abstract In humans, adolescence is a time of dynamic behavioral changes, including transient decrease in affect associated with being among family members. Here, we found that the reward value interactions siblings adolescent male mice followed similar course to humans: high preadolescence, mid-adolescence and return initial level late adolescence, as observed social conditioned place preference task. The change was specific interaction, rewarding effect cocaine actually increased during...
Abstract Social interactions can be and often are rewarding. The effect of social contact strongly depends on circumstances, the reward may driven by varied motivational processes, ranging from parental or affiliative behaviors to investigation aggression. Reward associated with nonreproductive in rodents is measured using conditioned place preference (sCPP) paradigm, where a change for an initially neutral context confirms reinforcing effects contact. Here, we revised sCPP method reexamined...
Repeated administration of subanesthetic doses ketamine is a model psychosis-like state in rodents. In mice, this treatment produces range behavioral deficits, including impairment social interactions and locomotion. To date, these phenotypes were described primarily the Swiss C3H/HeHsd mouse strains. A few studies investigated ketamine-induced behaviors C57BL/6J strain, but to our knowledge C57BL/6N strain was not thus far. This surprising, as both C57BL/6 sub-strains are widely used...
Opioid signaling controls the activity of brain's reward system. It is involved in hedonic effects rewards and has essential roles reinforcement motivational processes. Here, we focused on opioid through mu delta receptors dopaminoceptive neurons evaluated role these play reward-driven behaviors. We generated a genetically modified mouse with selective double knockdown expressing dopamine receptor D1. Selective expression transgene was confirmed using immunostaining. Knockdown validated by...
TRIM28, a multi-domain protein, is crucial in the development of mouse embryos and maintenance embryonic stem cells’ (ESC) self-renewal potential. As epigenetic factor modulating chromatin structure, TRIM28 regulates expression numerous genes associated with progression poor prognosis many types cancer. Because similarities between highly dedifferentiated cancer cells normal pluripotent cells, we applied human induced (hiPSC) as model for stemness studies. For first time hiPSC, analyzed...
Heat Shock Protein A2 (HSPA2) is a member of the HSPA (HSP70) chaperone family and has critical role for male fertility. HSPA2 present in number somatic organs. Limited evidence suggests that may be involved regulating epithelial cell differentiation. also emerged as cancer-related chaperone; however, no consensus on its functional significance been reached so far. In this study, we compared phenotypic effects deficit non-transformed human bronchial cells (HBEC), lung, breast, cervical...
Abstract Opioid signaling controls the activity of brain’s reward system. It is involved in hedonic effects rewards and also has essential roles reinforcement motivational processes. Here, we focused on opioid through mu delta receptors dopaminoceptive neurons evaluated role these play reward-driven behaviors. We generated a genetically modified mouse with selective double knockdown expressing dopamine receptor D1. Selective expression transgene was confirmed using immunostaining. Knockdown...
Abstract Social interactions can be and often are rewarding. The effect of social contact strongly depends on circumstances, the reward may driven by varied motivational processes, ranging from parental or affiliative behaviors to investigation aggression. Reward associated with nonreproductive in rodents is measured using conditioned place preference (sCPP) paradigm, where a change for an initially neutral context confirms reinforcing effects contact. Here, we revised sCPP method reexamined...
Abstract Prosocial behavior, defined as voluntary behavior intended to benefit another, has long been regarded a primarily human characteristic. In recent years, it was reported that laboratory animals also favor prosocial choices in various experimental paradigms, thus demonstrating behaviors are evolutionarily conserved. Here, we investigated adult male and female C57BL/6 mice task where subject mouse is equally rewarded for entering any of the two compartments cage, but only compartment...
Repeated administration of subanesthetic doses ketamine is a model psychosis-like state in rodents. In mice, this treatment produces range behavioral deficits, including impairment social interactions and locomotion. To date, these phenotypes were described primarily the Swiss C3H/HeHsd mouse strains. A few studies investigated ketamine-induced behaviors C57BL/6J strain, but to our knowledge C57BL/6N strain was not thus far. This surprising, as both C57BL/6 strains are widely used...