A5056159828- Epigenetics and DNA Methylation
- Genomics and Chromatin Dynamics
- Pluripotent Stem Cells Research
- RNA modifications and cancer
- CRISPR and Genetic Engineering
- Hemoglobin structure and function
- Cancer, Hypoxia, and Metabolism
- Cancer-related gene regulation
- Erythrocyte Function and Pathophysiology
- Neonatal Health and Biochemistry
- Histone Deacetylase Inhibitors Research
- Renal and related cancers
- Genomics and Phylogenetic Studies
- RNA Interference and Gene Delivery
- NF-κB Signaling Pathways
- Ferroptosis and cancer prognosis
- Cancer Immunotherapy and Biomarkers
- FOXO transcription factor regulation
- Cytokine Signaling Pathways and Interactions
- Kruppel-like factors research
- Nuclear Structure and Function
- DNA Repair Mechanisms
- Ubiquitin and proteasome pathways
- Cancer Genomics and Diagnostics
- Genomics and Rare Diseases
Poznan University of Medical Sciences
2013-2024
Greater Poland Cancer Center
2013-2024
Roy Castle Lung Cancer Foundation
2010-2017
University of Liverpool
2010-2017
Abstract BACKGROUND: The UHRF1 gene possesses an essential role in DNA methylation maintenance, but its contribution to tumor suppressor hypermethylation primary human cancers currently remains unclear. METHODS: mRNA expression levels of , DNMT1 DNMT3A DNMT3B and E2F1 were evaluated 105 nonsmall cell lung carcinomas by quantitative polymerase chain reaction. status CDKN2A RASSF1 promoters was examined pyrosequencing. knocked down short hairpin RNA A549 adenocarcinoma cells. RESULTS: All 4...
Reprogramming to induced pluripotent stem cells (iPSCs) and differentiation of (PSCs) are regulated by epigenetic machinery. Tripartite motif protein 28 (TRIM28), a universal mediator Krüppel-associated box domain zinc fingers (KRAB-ZNFs), is known regulate both processes; however, the exact mechanism identity participating KRAB-ZNF genes remain unknown. Here, using reporter system, we show that TRIM28/KRAB-ZNFs alter DNA methylation patterns in addition H3K9me3 cause stable gene repression...
The KRAB-ZNF (Krüppel-associated box domain zinc finger) gene family is composed of a large number highly homologous genes, isoforms, and pseudogenes. proteins encoded by these whose expression often tissue-specific, act as epigenetic suppressors contributing to the addition repressive chromatin marks DNA methylation. Due its high complexity, has not been studied in sufficient detail, involvement members carcinogenesis remains mostly unexplored. In this study, we aimed provide comprehensive...
Lung cancer is a heterogeneous disease at both clinical and molecular levels, posing conceptual practical bottlenecks in defining key pathways affecting its initiation progression. Molecules with central role lung carcinogenesis are likely to be targeted by multiple deregulated may have prognostic, predictive, and/or therapeutic value. Here, we report that Tumor Progression Locus 2 (TPL2), kinase implicated the regulation of innate adaptive immune responses, fulfils as suppressor subject...
Cytoglobin (CYGB) is frequently downregulated in many types of human malignancies, and its exogenous overexpression reduces proliferation cancer cells. Despite implied tumour suppressor (TSG) functions, exact role carcinogenesis remains unclear as CYGB upregulation also associated with hypoxia aggressiveness. In this study, we explore the TSG CYGB, influence on phenotype cancerous cells under stress conditions clinical significance expression promoter methylation non-small cell lung (NSCLC)....
Head and neck squamous cell carcinoma (HNSCC) is one of the ten most common cancers. Most cancer cases originate from alcohol tobacco consumption. However, studies have demonstrated that human papillomavirus (HPV) infection, particularly HPV-16, may also significantly influence disease progression. The KRAB-ZNF family genes involved in epigenetic suppression, its involvement carcinogenesis subject extensive studies. available literature data demonstrate they play different roles, both as...
The global cancer burden remains high; thus, a better understanding of the molecular mechanisms driving carcinogenesis is needed to improve current prevention and treatment options. We previously detected ZNF643/ZFP69B gene upregulated in multiple tumors, we speculated it may play role tumor biology. To test this hypothesis, employed TCGA-centered databases correlate ZNF643 status with various clinicopathological parameters. also performed RNA-seq analysis vitro studies assessing cell...
Krüppel-associated box domain zinc finger protein (KRAB ZNF) explorer is a web-based tool for comprehensive characterization of the mRNA expression status KRAB-ZNF transcription factors in data from The Cancer Genome Atlas study. Key functionalities cover comparative analysis between normal and cancer tissues, an association with various pathological features, including survival analysis, global DNA methylation status, analyses isoform expressions levels tissues.KRAB ZNF available at...
TRIM28, a multi-domain protein, is crucial in the development of mouse embryos and maintenance embryonic stem cells’ (ESC) self-renewal potential. As epigenetic factor modulating chromatin structure, TRIM28 regulates expression numerous genes associated with progression poor prognosis many types cancer. Because similarities between highly dedifferentiated cancer cells normal pluripotent cells, we applied human induced (hiPSC) as model for stemness studies. For first time hiPSC, analyzed...
Dysregulation of histone deacetylases (HDACs) is closely associated with cancer development and progression. Here, we comprehensively analyzed the association between all HDAC family members several clinicopathological molecular traits solid tumors across 22 distinct tumor types, focusing primarily on stemness immunity. To this end, used publicly available TCGA data bioinformatic tools (i.e., GEPIA2, TISIDB, GSCA, Enrichr, GSEA). Our analyses revealed that class I II proteins are phenotypes....
Multicellular organisms comprise a variety of cell types that have the same genotype but distinct phenotypes. This diversity is possible because establishment specific epigenetic landscape stabilizes gene expression profiles are exclusive for particular type. Accumulating data indicate maintenance, loss, and reacquisition pluripotency dynamically regulated by alterations evoked subset cellular factors. A better understanding mechanisms involved in stem biology differentiation will improve...