A5005021337- RNA Research and Splicing
- RNA modifications and cancer
- RNA and protein synthesis mechanisms
- Metabolomics and Mass Spectrometry Studies
- MicroRNA in disease regulation
- Endoplasmic Reticulum Stress and Disease
- Biological and pharmacological studies of plants
- Calcium Carbonate Crystallization and Inhibition
- Cellular transport and secretion
- Genetics, Aging, and Longevity in Model Organisms
- Adipose Tissue and Metabolism
- Field-Flow Fractionation Techniques
- Ginseng Biological Effects and Applications
- Photosynthetic Processes and Mechanisms
- Tryptophan and brain disorders
- Cancer, Hypoxia, and Metabolism
- Ubiquitin and proteasome pathways
- Plant Molecular Biology Research
- RNA Interference and Gene Delivery
- Hippo pathway signaling and YAP/TAZ
- Legume Nitrogen Fixing Symbiosis
- Circadian rhythm and melatonin
- Methane Hydrates and Related Phenomena
- Genomics and Phylogenetic Studies
The Ohio State University
2017-2023
Seoul National University
2015-2023
Vietnam Military Medical University
2022
Hanoi University of Pharmacy
2022
National Library of Vietnam
2022
University of Birmingham
2022
Columbus Center
2022
University of Auckland
2019
Of the four human Argonaute (AGO) paralogs, only AGO2 has been shown to have slicer activity. The others (AGO1, AGO3 and AGO4) thought assemble with microRNAs form slicer-independent effector complexes that bind target mRNAs silence gene expression through translational repression deadenylation but not cleavage. Here, we report recombinant loaded miR-20a cleaves complementary RNAs, whereas let-7a, miR-19b or miR-16 does not, indicating activity this depends on guide RNA. Our cleavage assays...
Optimizing flowering time is crucial for maximizing crop productivity, but gaps remain in the knowledge of mechanisms underpinning temperate legume flowering. Medicago, like winter annual Arabidopsis, accelerates after exposure to extended cold (vernalization, V) followed by long-day (LD) photoperiods. In photoperiodic triggered through CO, a switch that directly activates FT gene encoding mobile florigen and potent activator several CYCLING DOF FACTORs (CDFs), including AtCDF1, act...
Abstract RNase P is a ribonucleoprotein (RNP) that catalyzes removal of the 5′ leader from precursor tRNAs in all domains life. A recent cryo-EM study Methanocaldococcus jannaschii (Mja) produced model at 4.6-Å resolution dimeric configuration, with each holoenzyme monomer containing one RNA (RPR) and copy five proteins (RPPs; POP5, RPP30, RPP21, RPP29, L7Ae). Here, we used native mass spectrometry (MS), photometry (MP), biochemical experiments (i) validate oligomeric state Mja vitro, (ii)...
Abstract Introduction Herbal medicines have been used for a long time all around the world. Since quality of herbal preparations depends on source materials, there has strong need to develop methods correctly identify origin materials. Objective To smartphone metabolomics platform as simpler and low‐cost alternative identification material source. Methodology Schisandra sinensis extracts from Korea China were prepared. The visible spectra samples measured by spectrometer platform. This...
Distinct functions mediated by members of the monopolar spindle-one-binder (MOB) family proteins remain elusive beyond evolutionarily conserved and well-established roles MOB1 (MOB1A/B) in regulating tissue homeostasis within Hippo pathway. Since MOB are adaptors, understanding how they engage protein-protein interactions help assemble complexes is essential to define full scope their biological functions. To address this, we undertook a proximity-dependent biotin identification approach...
ABSTRACT Distinct functions mediated by members of the monopolar spindle-one-binder (MOB) family proteins remain elusive beyond evolutionary conserved and well-established roles MOB1A B in regulating Hippo pathway. Since MOB are adaptors, understanding how they engage protein-protein interactions complexes assembly is essential to define full scope their biological functions. To address this, we undertook a proximity-dependent biotin identification (BioID) approach interactomes all seven...