A5100408168- Cardiac electrophysiology and arrhythmias
- Cardiac Arrhythmias and Treatments
- Cardiovascular Function and Risk Factors
- Ion channel regulation and function
- Cardiac Valve Diseases and Treatments
- Cardiac pacing and defibrillation studies
- Receptor Mechanisms and Signaling
- Neuroscience and Neural Engineering
- Cardiac Structural Anomalies and Repair
- Machine Learning in Bioinformatics
- Cardiac Arrest and Resuscitation
- Chemotherapy-induced cardiotoxicity and mitigation
- ECG Monitoring and Analysis
- Electrospun Nanofibers in Biomedical Applications
- Tissue Engineering and Regenerative Medicine
- Cancer Treatment and Pharmacology
- Hormonal and reproductive studies
- Mechanical Circulatory Support Devices
- Neurological disorders and treatments
- Signaling Pathways in Disease
- Congenital Heart Disease Studies
- Analog and Mixed-Signal Circuit Design
- Parathyroid Disorders and Treatments
- Estrogen and related hormone effects
- Sexual function and dysfunction studies
Emory University
2014-2025
University Health Network
2022
Toronto General Hospital
2022
Jinan University
2021
University of Alabama at Birmingham
2020-2021
Tufts Medical Center
2015-2019
Jinzhou Medical University
2018
Tufts University
2017
Children's Healthcare of Atlanta
2015-2016
McCrone Research Institute
2014
Parasympathetic stimulation of the heart, which provides protection from arrhythmias and sudden death, involves activation G protein–coupled inward rectifying K+ channel GIRK1/4 results in an acetylcholine-sensitive current, IKACh. We describe a unique relationship between lipid homeostasis, lipid-sensitive transcription factor SREBP-1, regulation cardiac parasympathetic response, development ventricular arrhythmia. In embryonic chick atrial myocytes, lowering by culture lipoprotein-depleted...
Although β-blockers can be used to eliminate stress-induced ventricular arrhythmias in patients with catecholaminergic polymorphic tachycardia (CPVT), this treatment is unsuccessful ∼25% of cases. Induced pluripotent stem cell-derived cardiomyocytes (iPSC-CMs) generated from these have potential for use investigating the phenomenon, but it remains unknown whether they recapitulate patient-specific drug responses β-blockers. This study assessed inadequacy β-blocker therapy an individual...
Uremic cardiomyopathy is responsible for high morbidity and mortality rates among patients with chronic kidney disease (CKD), but the underlying mechanisms contributing to this complex phenotype are incompletely understood. Myocardial deformation analyses (ventricular strain) of mild CKD have recently been reported predict adverse clinical outcome. We aimed determine if early myocardial dysfunction in a mouse model could be detected using ventricular strain analyses. was induced 5-week-old...
Aims: To evaluate the ability of N-acetylglucosamine (GlcNAc) decorated nanoparticles and their cargo to modulate calcium handling in failing cardiac myocytes (CMs). Materials & methods: Primary CMs isolated from normal hearts were treated with GlcNAc order assess correct dysfunctional myocytes. Results conclusion: particles reduced aberrant release restored sarcomere function. Additionally, encapsulation a small calcium-modulating protein, S100A1, also showed improved regulation. Thus,...
Chloride (Cl-) channels participate in the regulation of cardiac function response to stress although underlying regulatory mechanism remains poorly understood. This study was designed examine impact pro-apoptotic stimulus staurosporine (STS) on volume-sensitive outwardly rectifying Cl- current (ICl,Vol) cardiomyocytes and possible involved with a focus phosphatidylinositol-3 kinase (PI3K)/Akt. Primary cultured rat neonatal were subjected hypotonic isotonic environment presence or absence...
Type 1 diabetic Akita mice develop severe cardiac parasympathetic dysfunction that we have previously demonstrated is due at least in part to an abnormality the response of end organ stimulation. Specifically, had shown hypoinsulinemia heart results attenuation G-protein coupled inward rectifying K channel (GIRK) which mediates negative chronotropic stimulation decreased expression GIRK1 and GIRK4 subunits channel. We further under control Sterol Regulatory element Binding Protein (SREBP-1),...
Second-generation antipsychotics (SGAs) play a critical role in current treatment of schizophrenia (SCZ). It has been observed that sinus bradycardia, rare but certain situations life threatening adverse drug reaction, can be induced by SGAs across different populations. However, the roles genetic factors this phenomenon have not studied yet. In present study, genome-wide association study single nucleotide polymorphisms (SNPs) was performed on Chinese Han SCZ patients to identify...
Ryanodine receptor 2 (RyR2) plays an important role in maintaining the normal heart function, and mutantions can lead to arrhythmia, failure other diseases. In this study, we successfully identified a piggyBac translocated RyR2 gene heterozygous mouse model (RyR2-PBmice) by tracking red fluorescent protein (RFP) genotyping PCR. Cardiac function tests showed that there was no significant difference between RyR2-PBmice corresponding wild-type mice (WTmice), regardless of whether they were...
Abstract A patient with heart failure due to dilated ischemic cardiomyopathy presented in cardiogenic shock for institution of veno‐arterial extracorporeal membrane oxygenation as a bridge cardiac transplantation. To provide adequate venous drainage and simultaneous decompression the left atrium (indirect ventricular venting), single cannula was placed across interatrial septum so that distal orifice side ports were located within proximal set positioned at cavoatrial junction....
Introduction: Diabetes mellitus is associated with increased risk of sudden cardiac death. Little evidence exists to support specific mechanisms account for this association. We studied the inducibility ventricular tachycardia (VT) in type I diabetic Akita mouse and ionic molecular arrhythmogensis. Methods: Inducibility VT was by programmed stimulation optical mapping. Left myocytes were isolated electrophysiology calcium imaging studies. Sarcomere shortening Ca 2+ transients measured using...
Introduction: The underlying mechanisms contributing to uremic cardiomyopathy during chronic kidney disease (CKD) are poorly understood, limiting treatment options. Hypothesis: We aimed determine if altered calcium (Ca2+) handling in cardiomyocytes contributes diastolic dysfunction a mouse model of CKD. Methods: CKD was induced male 129X1/SvJ mice through five-sixths nephrectomy two-stage surgery. Age-matched served as controls. Transthoracic echocardiography and speckle-tracking based...
Objective To explore the predictive value of routine echocardiographic and electrocardiographic parameters in late gadolinium enhancement (LGE) hypertrophic cardiomyopathy (HCM). Methods The study population consisted a consecutive series 95 HCM patients.According to presence LGE on cardiac magnetic resonance (CMR), these patients were divided into two groups: with (n=71) without (n=24). The echocardiography electrocardiography compared between groups. ROC Logistic analysis made find...
Introduction: Diabetes increases ventricular tachycardia (VT) and sudden cardiac death risk in humans. We previously found the type I diabetic (DMI) heart displays: reduced responsiveness to parasympathetic stimulation; increased QRS/T Wave alternans (marker of proarrhythmic calcium dyshomeostasis); hyperactive GSK3beta. Cardiac stimulation promotes production intracellular cyclic GMP (cGMP). The effects cGMP its downstream effector PKG, on these indices VT II diabetes (DMII) remain poorly...