A5001214223- Ion channel regulation and function
- Nicotinic Acetylcholine Receptors Study
- Orthopedic Infections and Treatments
- Total Knee Arthroplasty Outcomes
- Orthopaedic implants and arthroplasty
- Nail Diseases and Treatments
- Insect and Pesticide Research
- Plant Pathogens and Fungal Diseases
- Venomous Animal Envenomation and Studies
- Click Chemistry and Applications
- Hepatitis B Virus Studies
- Connexins and lens biology
- Liver Disease Diagnosis and Treatment
- Molecular Sensors and Ion Detection
- Synthesis of Organic Compounds
- Hepatitis C virus research
- Synthesis and biological activity
- Cholinesterase and Neurodegenerative Diseases
- Computational Drug Discovery Methods
- Chemical Synthesis and Analysis
- Chemical Synthesis and Reactions
- Fungal Infections and Studies
- Metal complexes synthesis and properties
Russian New University
2022
Peoples' Friendship University of Russia
2022
City University of New York
2014-2019
Brooklyn College
2017-2019
The Graduate Center, CUNY
2014-2017
York College, City University of New York
2012
Chronic hepatitis B virus infection cannot be cured by current therapies, so new treatments are urgently needed. We recently identified novel inhibitors of the ribonuclease H that suppress viral replication in cell culture. Here, we employed immunodeficient FRG KO mice whose livers had been engrafted with primary human hepatocytes to ask whether can vivo. Humanized infected were treated for two weeks #110, an α-hydroxytropolone, and #208, N-hydroxypyridinedione. Hepatitis titers S e antigen...
Disulfide-rich peptide toxins found in the secretions of venomous organisms such as snakes, spiders, scorpions, leeches, and marine snails are highly efficient effective tools for novel therapeutic drug development. Venom have been used extensively to characterize ion channels nervous system platelet aggregation haemostatic systems. A significant hurdle characterizing disulfide-rich from animals is obtaining quantities needed sequence structural analyses. Presented here a strategy...
Cryptococcus neoformans is a pathogen that common in immunosuppressed patients. It can be treated with amphotericin B and fluconazole, but the mortality rate remains 15 to 30%. Thus, novel more effective anticryptococcal therapies are needed. The troponoids based on natural products isolated from western red cedar, have broad range of antimicrobial activities. Extracts cedar inhibit growth several fungal species, neither extracts nor troponoid derivatives been tested against C. We screened...
Introduction. The frequency of hip arthroplasty is steadily increasing throughout the world and, although this operation has become routine, likelihood postoperative complications reaches 4.3 % [1]. most dangerous them are infectious lesions in area endoprosthesis and adjacent tissues. At same time, addition to threat generalization process, there functional disorders joint a general deterioration quality life patient. Timely diagnosis treatment process related can minimize adverse effects...
Multiple tryptophan (Trp) proteins are not amenable to fluorescence study because individual residue emission is resolvable. Biosynthetic incorporation of an indole analogue such as 5-hydroxyindole has provided sufficient spectroscopic resolution low quantum yield and small shift. Here, used the starting framework for building a blue emitting fluorophore high yield, 2-phenyl-6H-oxazolo[4,5-e]indole (PHOXI). This three reagent reaction completed in 10 min under ambient conditions borate...
Introduction. One of the rare complications following hip arthroplasty is periprosthetic joint infection (PJI). Two-stage revision gold standard in treatment deep large joints, providing high probability process resolution as well functional recovery limb and elimination pain syndrome. Aim: to improve results patients with after primary arthroplasty. Materials Methods. 121 (62 main group 59 control group) were included study. In group, was performed using a two-stage technique implantation...