The enhanced release of reactive oxygen species from activated neutrophils plays important role in the pathogenesis inflammatory bowel disease. We previously reported that radon inhalation activates antioxidative functions various organs mice. In this study, we examined protective effects on dextran sulfate sodium- (DSS) induced colitis mice which were subjected to DSS for 7 days. Mice continuously treated with air only (sham) or at a concentration 2000 Bq/m³ day before administration end...

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTMultiple binding modes for the receptor-bound conformations of cyclic AII agonistsKrystina Plucinska, Takahiro Kataoka, Mitsuaki Yodo, Wayne L. Cody, J. X. He, Christine Humblet, G. H. Lu, Elizabeth Lunney, Terry C. Major, and Cite this: Med. Chem. 1993, 36, 13, 1902–1913Publication Date (Print):June 25, 1993Publication History Published online1 May 2002Published inissue 25 June...

This is the first report to provide radiation doses, arising from inhalation of radon itself, in mice and rats. To quantify absorbed doses organs tissues mice, rats, humans, we computed behavior inhaled their bodies on basis a physiologically based pharmacokinetic (PBPK) model. It was assumed that dissolved blood entering gas exchange compartment transported any tissue by circulation be instantaneously distributed according tissue/blood partition coefficient. The calculated concentrations...

Abstract This is the first report to provide radiation doses, arising from inhalation of radon itself, in mice and rats. To quantify absorbed doses organs tissues mice, rats, humans, we computed behavior inhaled their bodies on basis a physiologically based pharmacokinetic (PBPK) model. It was assumed that dissolved blood entering gas exchange compartment transported any tissue by circulation be instantaneously distributed according tissue/blood partition coefficient. The calculated...

We examined dose–dependent or dose rate–dependent changes of superoxide dismutase (SOD) activity using a new large-scale facility for exposing small animals to radon. Mice were exposed radon at concentration 250, 500, 1000, 2000, 4000 Bq/m3 0.5, 1, 2, 4, 8 days. When mice 2000 day•Bq/m3, activation SOD activities in plasma, liver, pancreas, heart, thymus, and kidney showed dose–rate effects. Our results also suggested that continuous exposure increased activity, but transiently returned...

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTMolecular design by cycloaddition reactions. XXI. Periselectivity of reactions fulvenes with heterodienes and heterodienophilesTadashi Sasaki, Ken Kanematsu, Takahiro KataokaCite this: J. Org. Chem. 1975, 40, 9, 1201–1205Publication Date (Print):May 1, 1975Publication History Published online1 May 2002Published inissue 1 1975https://pubs.acs.org/doi/10.1021/jo00897a004https://doi.org/10.1021/jo00897a004research-articleACS PublicationsRequest reuse...

We have previously reported that radon inhalation activates anti-oxidative functions and inhibits carbon tetrachloride (CCl4)-induced hepatopathy. It has also been antioxidant vitamins can inhibit CCl4-induced In the current study, we examined comparative efficacy of treatment with radon, ascorbic acid α-tocopherol on Mice were subjected to intraperitoneal injection CCl4 after inhaling approximately 1000 or 2000 Bq/m3 for 24 h, immediately (100, 300, 500 mg/kg bodyweight) bodyweight)....

It is well known that cigarette tobaccos contain naturally occurring radioactive nuclides such as (210)Pb and (210)Po. In many countries, the radioactivity of has been measured to estimate effective dose from smoking inhalation. The present study covered 24 brands including top 20 sales in Japan between April 2008 March 2009. activity concentrations were by gamma-ray spectrometry, then those its progeny ((210)Po) evaluated assuming equilibrium two nuclides. Their range 2-14 mBq cigarette(-1)...

ABSTRACT Radon therapy using radon (222Rn) gas is classified into two types of treatment: inhalation and drinking water containing radon. Although short- or long-term intake spa effective in increasing gastric mucosal blood flow, useful for treating chronic gastritis ulcer, the underlying mechanisms precise effects protection against injury are unclear. In present study, we examined protective hot spring on ethanol-induced mice. Mice inhaled at a concentration 2000 Bq/m3 24 h were provided...

Abstract The effect of side‐chain cyclization on accessible backbone conformations tripeptides, X‐Ala‐Y (X and/or Y = Cys, Hey ( Hcy: homocysteine ), cis 4‐mercaptoproline (MPc), and trans (MPt)), was elucidated using two variants systematic conformational search. In addition to through a disulfide bond, the thioether (‐S‐CH 2 ‐) amide (‐CO‐NH‐) analogues Cys‐Ala‐Cys Hcy‐Ala‐Hcy were evaluated. number valid allowed ϕ Ψ;space evaluated for each compound, ability cyclic tripeptides accommodate...

The catalase activities in blood and organs of the acatalasemic (C3H/AnLCsbCsb) mouse C3H strain are lower than those normal (C3H/AnLCs aCsa) mouse. We examined effects prior low-dose (0.5 Gy) X-ray irradiation, which reduced oxidative damage under carbon tetrachloride-induced hepatopathy or mice. mice showed a significantly activity higher glutathione peroxidase compared with Moreover, irradiation increased liver to level similar that liver. Pathological examinations analyses glutamic...

We have reported that low-dose, unlike high-dose, irradiation enhanced antioxidation function and reduced oxidative damage. On the other hand, ischemia-reperfusion injury is induced by reactive oxygen species. In this study, we examined inhibitory effects of prior low-dose X-irradiation on in mouse paw. BALB/c mice were irradiated sham or 0.5 Gy X-ray. At 4 hrs after irradiation, left hind leg was bound 10 times with a rubber ring for 0.5, 1, 2 paw thickness measured. Results show swelling...

Abstract Although radon inhalation increases superoxide dismutase (SOD) activities in mouse organs, the mechanisms and pathways have not yet been fully clarified. The aim of this study was to determine details SOD activation brain tissue following at concentrations 500 or 2000 Bq/m3 for 24 h. After inhalation, brains were removed quickly analysis. Radon increased manganese (Mn)-SOD level mitochondrial activity. However, differences significant. There no changes Cu/Zn-SOD cytosolic nuclear...