A5068476945- Gut microbiota and health
- RNA Research and Splicing
- MicroRNA in disease regulation
- RNA and protein synthesis mechanisms
- RNA modifications and cancer
- Lipid metabolism and biosynthesis
- Probiotics and Fermented Foods
- Circular RNAs in diseases
- Wnt/β-catenin signaling in development and cancer
- Neuroendocrine regulation and behavior
- Cancer-related molecular mechanisms research
- Plant and Fungal Interactions Research
- Microbial Community Ecology and Physiology
- Empathy and Medical Education
- Histone Deacetylase Inhibitors Research
- Invertebrate Immune Response Mechanisms
- Reproductive Biology and Fertility
- Apelin-related biomedical research
- Cystic Fibrosis Research Advances
- Protein Tyrosine Phosphatases
- Mycobacterium research and diagnosis
- Fibroblast Growth Factor Research
- Liver physiology and pathology
- Photosynthetic Processes and Mechanisms
- Ubiquitin and proteasome pathways
Centre National de la Recherche Scientifique
2017-2020
Université de Bordeaux
2014-2020
Laboratoire Bordelais de Recherche en Informatique
2018-2020
Kerala Veterinary and Animal Sciences University
2020
Inserm
2014-2019
Immunology from Concept and Experiments to Translation
2018-2019
Biotherapy of Genetic Diseases, Inflammatory Disorders and Cancers
2016-2018
Bordeaux Population Health
2015-2017
University of Manchester
2011-2016
Bangor University
2012
ABSTRACT Dysbiosis is a key term in human microbiome research, especially when patterns are associated with disease states. Although some questions have been raised about how this applied, its use continues undiminished the literature. We investigate ways which researchers discuss dysbiosis and then assess impact of different concepts on research. After an overview term’s historical roots, we conduct quantitative qualitative analyses large selection contemporary statements. categorize both...
Surgery and cisplatin‐based treatment of hepatoblastoma (HB) currently guarantee the survival 70%‐80% patients. However, some important challenges remain in diagnosing high‐risk tumors identifying relevant targetable pathways offering new therapeutic avenues. Previously, two molecular subclasses HB have been described, C1 C2, with C2 being subgroup poorest prognosis, a more advanced tumor stage, worst overall rate. An associated 16‐gene signature to discriminate tumoral subgroups was...
MicroRNAs are essential post-transcriptional regulators. Many animal microRNAs clustered in the genome, and it has been shown that may be transcribed as a single transcript. Polycistronic often members of same family, suggesting role tandem duplication emergence clusters. The mir-2 microRNA family is largest Drosophila melanogaster, with 8 mostly genome. Previous studies suggest copy number genomic distribution subject to significant change during evolution. effects such changes on their...
Abstract Microbiota-gut-brain (MGB) research is a fast-growing field of inquiry with important implications for how human brain function and behaviour are understood. Researchers manipulate gut microbes (“microbiota”) to reveal connections between intestinal microbiota normal functions (e.g., cognition, emotion, memory) or pathological states anxiety, mood disorders, neural developmental disorders such as autism). Many claims made about causal relationships behaviour. By uncovering these...
Spondyloarthritis (SpA) pathophysiology remains largely unknown. While the association with genetic factors has been established for decades, influence of gut microbiota is only an emerging direction research. Despite remarkable efficacy anti-TNF-α treatments, non-responders are frequent and no predictive patient outcome have identified. Our objective was to investigate modifications intestinal composition in patients suffering from SpA three months after treatment. We performed 16S rDNA...
Cystic fibrosis (CF) is a systemic genetic disease that leads to pulmonary and digestive disorders. In the majority of CF patients, intestine site chronic inflammation microbiota disturbances. The link between gut dysbiosis still poorly understood. main objective this study was assess composition in children depending on their intestinal inflammation. We collected fecal samples from 20 with CF. Fecal calprotectin levels were measured analyzed by 16S rRNA sequencing. observed associated...
The unconventional splicing of Hac1 by the ribonuclease Ire1 is a key event in activation unfolded protein response (UPR) Saccharomyces cerevisiae. This independent spliceosome and mediated secondary structure at intron-exon boundaries mRNA. Similar was also described for gene Xbp1 human, mouse, C. elegans D. melanogaster, five other fungi. We used reported RNA structures to build multiple sequence alignment Infernal package search homologous structures. identified non-canonical intron 128...
Introns in protein-coding genes are very rare hemiascomycetous yeast genomes. It has been suggested that these species have experienced extensive intron loss during their evolution from the postulated intron-rich fungal ancestor. However, no intron-devoid identified and some of introns remaining within genomes intron-poor species, such as Saccharomyces cerevisiae , appear to be beneficial growth under stress conditions. In order reveal pattern retention better understand mechanisms...
Hepatoblastoma (HBL) is the most common pediatric liver cancer. In this malignant neoplasm, beta‐catenin protein accumulates and increases Wnt signaling due to recurrent activating mutations in catenin‐beta 1 ( CTNNB1 ) gene. Therefore, a key therapeutic target HBL. However, controlling production with molecules has been challenging. New biological studies could provide alternative solutions for treatment of HBL, especially advanced tumors metastatic disease. study, we identified microRNAs...
Glypican-3 (GPC3) is an oncogene, frequently upregulated in liver malignancies such as hepatocellular carcinoma (HCC) and hepatoblastoma constitutes a potential molecular target for therapy cancer. Using functional screening system, we identified 10 new microRNAs controlling GPC3 expression malignant cells, five of them e.g. miR-4510, miR-203a-3p, miR-548aa, miR-376b-3p miR-548v reduce expression. These 5 were significantly downregulated tumoral compared to non-tumoral inhibited tumor cell...
Apelin is a well-established mediator of survival and mitogenic signaling through the apelin receptor (Aplnr) has been implicated in various cancers; however, little known regarding Elabela (ELA/APELA) signaling, also mediated by Aplnr, its role conversion precursor proELA into mature ELA cancer are unknown. Here, we identified function mTORC1 as an essential that repressed kidney tumor cell growth, migration, survival. Moreover, sunitinib showed synergistic effect repressing growth...
The Saccharomyces cerevisiae genome has undergone extensive intron loss during its evolutionary history. It been suggested that the few remaining introns (in only 5% of protein-coding genes) are retained because their impact on function under stress conditions. Here, we explore possibility novel noncoding RNA structures (ncRNAs) embedded within intronic sequences and contributing to phenotype retention in yeast. We employed de novo structure prediction tools screen S. 36 other fungi....
Tissue regeneration requires expression of a large, unknown number genes to initiate and maintain cellular processes such as proliferation, extracellular matrix synthesis, differentiation migration. A unique model simulate this process in controlled manner is the re-growth caudal fin zebrafish after amputation. Within tissue stem cells differentiate into fibroblasts, epithelial endothelial well melanocytes. Many implicated are deregulated cancer. We therefore undertook systematic gene study...
Diffuse midline glioma (DMG) is a pediatric malignancy with poor prognosis. Most children die less than one year after diagnosis. Recently, mutations in histone H3 have been identified and are believed to be oncogenic drivers. Targeting this epigenetic abnormality using deacetylase (HDAC) inhibitors such as panobinostat (PS) therefore novel therapeutic option currently evaluated clinical trials.BH3 profiling revealed engagement an irreversible apoptotic process of cells exposed PS confirmed...
// Emilie Indersie 1, 2, * , Katarzyna B. Hooks Caroline Capdevielle 2 Monique Fabre 3 Nathalie Dugot-Senant 4 Angélique Desplat Sébastien Lepreux 5 Aksam Merched Christophe F. Grosset and Martin Hagedorn 1 University Bordeaux, INSERM U1035, miRCaDe team, Biothérapie des Maladies Génétiques, Inflammatoires et du Cancer, Bordeaux 33076, France Research in Translational Oncology (Bariton), Necker Hospital, Paris 75015, Plateforme d’histologie UMS 005,...
Abstract Our analysis of microbiota-gut-brain (MGB) research took MGB to task for some its methods, concepts, and interpretations. Commentators then raised numerous issues about the neuroscientific microbiome aspects how it can be understood as a field. We respond by addressing dimensionality (scope depth) causal focus MGB.
ABSTRACT The Saccharomyces cerevisiae genome has undergone extensive intron loss during its evolutionary history. It been suggested that the few remaining introns (in only 5% of protein-coding genes) are retained because their impact on function under stress conditions. Here, we explore possibility novel non-coding RNA structures (ncRNAs) embedded within intronic sequences and contributing to phenotype retention in yeast. We employed de novo structure prediction tools screen S. 36 other...