A5042865371- Cardiac Valve Diseases and Treatments
- Shape Memory Alloy Transformations
- Lattice Boltzmann Simulation Studies
- Paleontology and Evolutionary Biology
- Fluid Dynamics Simulations and Interactions
- Neuroscience and Neural Engineering
- Mechanical Circulatory Support Devices
- 3D Printing in Biomedical Research
- Orthopaedic implants and arthroplasty
- Hydrogels: synthesis, properties, applications
- Mechanical Behavior of Composites
- Electrospun Nanofibers in Biomedical Applications
- Bone Tissue Engineering Materials
- Fire effects on concrete materials
- Metal and Thin Film Mechanics
- Smart Materials for Construction
- Surface Treatment and Residual Stress
- Tissue Engineering and Regenerative Medicine
- Structural Health Monitoring Techniques
- Atrial Fibrillation Management and Outcomes
- Aortic Disease and Treatment Approaches
- Cardiac Arrhythmias and Treatments
- Elasticity and Material Modeling
- Fluid Dynamics and Vibration Analysis
- Ichthyology and Marine Biology
Ri.MED
2021-2025
University College London
2021-2022
University of Palermo
2019-2022
A large majority of thrombi causing ischemic complications under atrial fibrillation (AF) originate in the left appendage (LAA), an anatomical structure departing from atrium, characterized by a morphological variability between individuals. This work analyses hemodynamics simulated for different patient-specific models LAA means computational fluid-structure interaction studies, modeling effect changes contractility and shape resulting AF.Three operating conditions were analyzed: sinus...
Fluid-structure interaction (FSI) is required in the study of several cardiovascular engineering problems were mutual between pulsatile blood flow and tissue structures essential to establish biomechanics system. Traditional FSI methods are partitioned approaches where two independent solvers, one for fluid structure, asynchronously coupled. This process results into high computational costs. In this work, a new scheme which avoids coupling different solvers presented framework truly...
Valve-sparing procedures are surgical techniques allowing to restore adequate function of the native aortic valve by replacing dysfunctional ascending aorta with a prosthetic conduit. A number currently used, such as Yacoub's remodelling and David's reimplantation, based on regular straight More recently, De Paulis proposed use bulging conduits reconstruct shape Valsalva sinuses. This work investigates impact valve-sparing technique function.The performance 3 porcine roots (Medtronic...
Biological soft tissues and polymers used in biomedical applications (e.g. the cardiovascular area) are hyperelastic incompressible materials that commonly operate under multi-axial large deformation fields. Their characterisation requires biaxial tensile testing. Due to typically small sample size, gripping of specimens relies on rakes or sutures, where specimen is punctured at edges gauge area. This approach necessitates an apron, excess material around region. work analyses apron...
Thanks to its unique behaviour characterised by a superelastic response, Nitinol has now become the material of preference in number critical applications, especially area medical implants. However, reversible phase transformation producing exceptional comportment is also responsible for phenomena that make mechanical characterisation particularly complex, hindering assumptions at very basis common uniaxial tensile testing. This necessarily reduces level safety and design optimization...
Nickel–Titanium (NiTi) shape memory alloys subjected to cyclic loading exhibit reversible temperature changes whose modulation is correlated with the applied load. This reveals presence of thermomechanical heat sources activated by stresses. One such source elastocaloric effect, accounting for latent Austenite–Martensite phase transformation. It is, however, observed that when amplitude loads not sufficient activate or further propagate this transformation, material still exhibits a strong...
Abstract This paper focuses on the design, fabrication, and characterization of a platform aiming to dynamically culture cells under mechanical stimulation. The platform, made polymethylmethacrylate (PMMA), allows real-time stimuli, providing valuable insights for living tissue models. Through testing dynamic microfluidic tests, chip functionality was assessed. experimental results validation showcases potential device in mimicking physiological conditions, offering promising avenue...
Thanks to its unique behaviour characterised by a superelastic response, Nitinol has now become the material of preference in number critical applications, especially area medical implants. However, reversible phase transformation producing exceptional comportment is also responsible for phenomena that make mechanical characterisation particularly complex, hindering assumptions at very basis common uniaxial tensile testing. This necessarily reduces level safety and design optimization...