A5074617190- Mesenchymal stem cell research
- 3D Printing in Biomedical Research
- Tissue Engineering and Regenerative Medicine
- Cancer Cells and Metastasis
- Pluripotent Stem Cells Research
- Cancer Immunotherapy and Biomarkers
- Organ and Tissue Transplantation Research
- Bone Tissue Engineering Materials
- MicroRNA in disease regulation
- Cancer Genomics and Diagnostics
- Immunotherapy and Immune Responses
- Immune Cell Function and Interaction
- Biomedical Ethics and Regulation
- Hydrogels: synthesis, properties, applications
- Receptor Mechanisms and Signaling
- Extracellular vesicles in disease
- Neurogenesis and neuroplasticity mechanisms
- Cell death mechanisms and regulation
- T-cell and B-cell Immunology
- Nerve injury and regeneration
- Molecular Biology Techniques and Applications
- Electrospun Nanofibers in Biomedical Applications
- RNA Interference and Gene Delivery
- Silk-based biomaterials and applications
- Myeloproliferative Neoplasms: Diagnosis and Treatment
University of Palermo
2014-2025
University of Trieste
2024
Laboratoire des Sciences de l'Ingénieur, de l'Informatique et de l'Imagerie
2022
University of Palermo
2020
Center For Reconstructive Urethral Surgery
2019
Texas Plastic Surgery
2019
Azienda Ospedaliera Universitaria Policlinico "Paolo Giaccone" di Palermo
2017
University of Milan
2004-2014
University of Padua
2014
Veneto Institute of Molecular Medicine
2014
Rationale : The sympathetic nervous system plays a fundamental role in the regulation of myocardial function. During chronic pressure overload, overactivation induces release catecholamines, which activate β-adrenergic receptors cardiomyocytes and lead to increased heart rate cardiac contractility. However, stimulation leads impaired function, β-blockers are widely used as therapeutic agents for treatment disease. MicroRNA-133 (miR-133) is highly expressed myocardium involved controlling...
Inflammation plays a major pathological role in spinal cord injury (SCI). Although antiinflammatory treatment using the glucocorticoid methyprednisolone sodium succinate (MPSS) improved outcomes several multicenter clinical trials, additional experience suggests that MPSS is only modestly beneficial SCI and poses risk for serious complications. Recent work has shown erythropoietin (EPO) moderates CNS tissue injury, part by reducing inflammation, limiting neuronal apoptosis, restoring...
Abstract Melanoma is one of the most sensitive tumors to immune modulation, and major challenge for melanoma patients’ survival checkpoint inhibitor (ICI) therapy. γδ T lymphocytes play an antitumoral role in a broad variety including they are optimal candidates cellular immunotherapy. Thus, comprehensive analysis correlation between cells receptors context was conducted, with aim devising innovative combined immunotherapeutic strategy. In this study, using GEPIA2.0 database, significant...
Abstract Colorectal cancer has provided an important model to test the stem cell hypothesis of origin, which implies that arises as a result genetic aberrations in cells leading deregulation proliferation/differentiation balance. We and others have demonstrated that, similarly other solid tumors, colon carcinogenesis progression are dictated by highly apoptosis‐resistant stem‐like cells. Our data suggested protection from apoptosis is achieved autocrine production interleukin‐4 (IL‐4)...
Inflammatory bowel disease [IBD] is a complex chronic inflammatory of the human gut with no clear aetiology. Traditionally, dysregulated adaptive immune responses play an important role even though accumulating evidence suggests also for innate immunity. Because well-known plasticity γδ T cells, we investigated their percentage occurrence, phenotypic features and effector functions in intestinal mucosa early-onset long-standing IBD patients, as compared to healthy subjects.Fresh biopsies...
Two‐dimensional (2D) cell cultures have been extensively used to investigate stem biology, but new insights show that the 2D model may not properly represent potential of tissue origin. Conversely, three‐dimensional exhibit protein expression patterns and intercellular junctions are more representative their in vivo condition. Multiclonal cells grow suspension defined as “spheroids,” we previously demonstrated spheroids from adipose‐derived (S‐ASCs) displayed enhanced regenerative...
Abstract Calvarial defects can result from several causes. Tissue engineering hold the potential to restore native form and protective function. We have recently shown that stemness differentiation ability of spheroids adipose-derived stem cells (S-ASCs) promotes osteoblasts growth within Integra in a small vertebral lesion. In our study, we aimed test osteogenic S-ASCs aiding regeneration calvarial defect. Groups containing showed increased bone at defect-Integra interface compared with...
Bones and teeth represent a common finding in ancient DNA studies forensic casework, even after long burial. Genetic typing is the gold standard for personal identification of skeletal remains, but there are two main factors involved successful such samples: (1) set-up an efficient extraction method; (2) most suitable element downstream genetic analyses. In this paper, protocol based on processing 0.5 g bone powder decalcified using Na2EDTA proved to be semi-automated workflow Maxwell® FSC...
Introduction: Spheroids are spherical aggregates of cells that mimic the three-dimensional (3D) architecture tissues more closely than traditional two dimensional (2D) cultures. adipose stem (SASCs) show special features such as high multilineage differentiation potential and immunomodulatory activity. These properties have been attributed to their secreted factors, cytokines growth factors. Moreover, a key role is played by extracellular vesicles (EVs), which lead heterogeneous cargo...