A5000262821- CRISPR and Genetic Engineering
- RNA and protein synthesis mechanisms
- RNA regulation and disease
- RNA Research and Splicing
- Advanced biosensing and bioanalysis techniques
- Animal Nutrition and Physiology
- Enzyme Structure and Function
- Viral Infections and Immunology Research
- Aquaculture Nutrition and Growth
- Genomics and Phylogenetic Studies
- Genetics, Aging, and Longevity in Model Organisms
- Metabolism, Diabetes, and Cancer
- RNA Interference and Gene Delivery
- Congenital heart defects research
- Cytomegalovirus and herpesvirus research
- Gene Regulatory Network Analysis
- Aquaculture disease management and microbiota
- Virus-based gene therapy research
- Melanoma and MAPK Pathways
- Protein Kinase Regulation and GTPase Signaling
- Genetic Syndromes and Imprinting
Yonsei University
2016-2024
Sungkyunkwan University
2023-2024
Handong Global University
2014
Hallym University
2014
We evaluated SpCas9 activities at 12,832 target sequences using a high-throughput approach based on human cell library containing single-guide RNA-encoding and sequence pairs. Deep learning-based training this large dataset of SpCas9-induced indel frequencies led to the development activity-predicting model named DeepSpCas9. When tested against independently generated datasets (our own those published by other groups), DeepSpCas9 showed high generalization performance. is available...
Pseudohypoparathyroidism type Ia (PHP Ia) is a disorder characterized by multiform hormonal resistance including parathyroid hormone (PTH) and Albright hereditary osteodystrophy (AHO). It caused heterozygous inactivating mutations within the Gs alpha-encoding GNAS exons. A 9-year-old boy presented with clinical laboratory abnormalities hypocalcemia, hyperphosphatemia, PTH resistance, multihormone AHO (round face, short stature, obesity, brachydactyly osteoma cutis) which were typical of PHP...