The effect of topography in three-dimensional (3D) printed polymer scaffolds on stem cell differentiation is a significantly underexplored area. Compared to two-dimensional (2D) biomaterials which various well-defined topographies have been incorporated and shown direct range behaviors including adhesion, cytoskeleton organization, differentiation, incorporating topographical features 3D challenging due the difficulty accessing inside porous scaffold. Only roughened strut surface has...

3D printed bioactive glass or bioceramic particle reinforced composite scaffolds for bone tissue engineering currently suffer from low concentration (<50 wt%) hence osteoconductivity. Meanwhile, composites with very high inorganic concentrations are brittle. Scaffolds combining content and ductility urgently required engineering. Herein, PCL/hydroxyapatite (HA) ceramic (up to 90 made ductile (>100% breaking strain) by adding poly(ethylene glycol) which is biocompatible FDA approved. The...

We report a conductive and biodegradable 3D printed polymer scaffold that promotes chondrogenic differentiation of chondroprogenitor cells. The material consists tetraniline-<italic>b</italic>-polycaprolactone-<italic>b</italic>-tetraaniline polycaprolactone.

Kratom (Mitragyna speciosa (Korth.) Havil.) has been used to reduce blood sugar and lipid profiles in traditional medicine, mitragynine is a major constituent kratom leaves. Previous data on the lipid-altering effects of are limited. In this study, phytochemical analyses mitragynine, 7-hydroxymitragynine, quercetin, rutin were performed extracts. The α-glucosidase pancreatic lipase activities investigated extracts mitragynine. LC-MS/MS analysis showed that contents from different. ethanol...

Osseointegration between biomaterial and bone is critical for the clinical success of many orthopaedic dental implants. However, mechanisms in vivo interfacial bonding formation role immune cells this process remain unclear. In study, we investigated bone-scaffold material interfaces two different 3D printed porous scaffolds (polymer/hydroxyapatite sintered hydroxyapatite) that elicited levels foreign body response (FBR). The polymer/hydroxyapatite composite more intensive FBR, which was...

Three-dimensional (3D) printing is a powerful manufacturing tool for making 3D structures with well-defined architectures wide range of applications.The field tissue engineering has also adopted this technology to fabricate scaffolds regeneration.The ability control architecture scaffolds, e.g.matching anatomical shapes and having defined pore size, since been improved significantly.However, the material surface these smooth does not resemble that found in natural extracellular matrix (ECM),...

IntroductionHerbal medicine has been integrated into Thai culture for many centuries. However, studies on using herbal in combination with antidiabetic agents glycemic control managing diabetes are limited. Herein, we aimed to assess the use of medicines different dosages and their association patients type 2 mellitus (T2DM).MethodsThis hospital-based study included 739 T2DM who consecutively visited four district hospitals Thailand. An interviewer-administered questionnaire was used collect...

The human liver cytochrome P450 (CYP) 2A6 and the respiratory CYP2A13 enzymes play role in nicotine metabolism activation of tobacco-specific nitrosamine carcinogens. Inhibition both could offer a strategy for smoking abstinence decreased risks diseases lung cancer. In this study, activity-guided isolation identified four flavonoids 1-4 (apigenin, luteolin, chrysoeriol, quercetin) from Vernonia cinerea Pluchea indica, hirsutinolide-type sesquiterpene lactones 5-8 V. cinerea, acetylenic...

Using phantom samples, we investigated the feasibility of spatially-offset Raman spectroscopy (SORS) as a tool for monitoring non-invasively mineralization bone tissue engineering scaffold in-vivo. The samples consisted 3D-printed scaffolds poly-caprolactone (PCL) and hydroxyapatite (HA) blends, with varying concentrations HA, to mimic mineralisation process. were covered by 4 mm layer skin simulate real in-vivo measurement conditions. At concentration HA approximately 1/3 that (~0.6 g/cm3),...

Menthol/fatty acid HDES enables higher incorporation of curcuminoids in water-rich matrices (3D printed hydrogel). It promotes fibroblast proliferation and, with curcuminoids, synergistically improves anti-biofilm activity.

Cigarette smoking is one of the major risk factors various diseases including respiratory and lung cancer. While liver-specific CYP2A6 associated with nicotine clearance addiction, metabolic activation tobacco-specific nitrosamine by lung-specific CYP2A13 can lead to tumorigenesis.It has been reported that inhibition enzymes flavonoids constituents could be an aids in cessation. This study demonstrates activity kaempferol myricetin structure-function relationship these two previously...

Mosquito-borne diseases, transmitted by mosquito vectors, continue to cause illness and death in many areas of the world, especially tropical subtropical countries. One control measures these diseases has been contingent on vector using synthetic chemical insecticides. Due environmental health concerns insecticides rise resistance mosquitoes, eco-friendly easily biodegradable natural plant compounds that are potential imperative for management. Over past decades, searches insecticidal...

A strong bonding (osseointegration) between biomaterial and bone is critical for the clinical success of many orthopaedic dental implants. However, how this interfacial formed in vivo role immune cells process not clear. In study, we investigated bone-material interfaces two different 3D printed porous scaffolds that elicited levels foreign body response (FBR). The polymer/hydroxyapatite composite more intensive FBR evidenced by components (macrophages/foreign giant cells, fibrous tissue)...

Cigarette smoking has been reported as the significant adverse effects on lung function, which can be evaluated by measuring forced expiratory volume in one second (FEV1), vital capacity (FVC), and ratio of FEV1 to FVC (FEV1/FVC) values.This study investigated prevalence tobacco use nicotine dependence among college students their stress levels inform targeted interventions for prevention cessation.A total 429 participants were interviewed face-to-face, 71.6% female 28.4% male. Pulmonary...