Nociceptive neuronal circuits are formed during embryonic and postnatal times when painful stimuli normally absent or limited. Today, medical procedures for neonates with health risks can involve tissue injury pain which the long-term effects unknown. To investigate impact of neonatal on development nociceptive circuitry, we used an animal model persistent hind paw peripheral inflammation. We found that, as adults, these animals exhibited spinal increased input segmental changes in primary...

Alteration in the intracellular signal transduction pathway primary afferent neurons may contribute to pain hypersensitivity. We demonstrated that very rapid phosphorylation of extracellular signal-regulated protein kinases (pERK) occurred DRG were taking part transmission various noxious signals. The electrical stimulation Aδ fibers induced pERK primarily with myelinated fibers. c-Fiber activation by capsaicin injection small unmyelinated containing vanilloid receptor-1 (VR-1), suggesting...

To investigate the intracellular signal transduction pathways involved in regulating gene expression of brain-derived neurotrophic factor (BDNF) primary afferent neurons, we examined activation extracellular signal-regulated protein kinase (ERK) dorsal root ganglion (DRG) neurons after peripheral inflammation and sciatic nerve transection. Peripheral induced an increase phosphorylation ERK, mainly tyrosine A-containing small-to-medium-diameter DRG neurons. The treatment mitogen-activated...

We investigated the expression of two candidate transducers noxious stimuli in peripheral tissues, vanilloid receptor subtype 1 (VR1) and P2X3, a subunit ionotropic P2X for ATP, spared L4 DRG neurons following L5 spinal nerve ligation, neuropathic pain model. VR1 mRNA increased small- medium-sized from first to 28th day after injury, this up-regulation corresponded well with development maintenance thermal hyperalgesia hind paw. The increase VR1-immunoreactive (ir) was confirmed at third...

We examined two possible mechanisms of neuropathic pain: contribution adjacent intact nerves and decrease in presynaptic inhibition at the central terminal injured primary afferent. To this end, we effects unilateral L5 spinal nerve ligation, which causes mechanical allodynia heat hyperalgesia ipsilateral hind paw, on gene expression L4 dorsal root ganglion (DRG) neurons using situ hybridization (ISH). Specifically, changes messenger RNAs (mRNAs) for neuropeptides have been reported to be...

Pain during inflammatory joint diseases is enhanced by the generation of hypersensitivity in nociceptive neurons peripheral nervous system. To explore signaling mechanisms mechanical inflammation, experimental arthritis was induced injection complete Freund's adjuvant (CFA) into synovial cavity rat knee joints. As a pain index, struggle threshold extension angle measured. In rats with arthritis, phosphorylation extracellular signal-regulated kinase (ERK), passive movement, increased...

Postoperative C-5 palsy is known as a common complication after cervical laminoplasty. The authors of this article have encountered postoperative more often when laminoplasty was combined with instrumented posterior spinal fusion than it performed alone. purpose clinical study to examine the incidence fifth nerve root (C-5 palsy) and surgical results in patients myelopathy who had undergone or without fusion.The retrospectively studied fusion.Clinical data on 58 were evaluated analyzed....

Abstract Purpose The purpose of this study was to examine the outcomes following opening‐wedge high tibial osteotomy (HTO) focusing on return sports in a consecutive series highly active patients who underwent unilateral procedure. Methods Sixty‐three with preoperative Tegner's activity score five or more HTO for varus osteoarthritic knees were included study. clinical results evaluated using Knee Injury and Osteoarthritis Outcome Score (KOOS) International Documentation Committee (IKDC)...

Background: Functional recovery and return to sports after fixation of osteochondritis dissecans (OCD) lesions the knee with osteochondral autologous transplantation (OAT) have not been well investigated. Purpose: To retrospectively evaluate functional clinical outcomes internal OAT for OCD. Study Design: Case series; Level evidence, 4. Methods: A consecutive series patients who underwent OCD between 2010 2020 were initially enrolled in study. Patients adult-onset those fragment removal...

Background: Meniscal saucerization combined with repair of a symptomatic discoid lateral meniscus (DLM) has been expanding. However, the significance meniscal involving complex or degenerative tears remains uncertain. Purpose/Hypothesis: The purpose this study was to assess radiological and clinical outcomes performed for DLM in children adolescents comparison historical control cohort undergoing subtotal meniscectomy. It hypothesized that would lead superior compared Study Design: Cohort...

Abstract Pyogenic spondylitis in older patients with osteoporosis presents significant challenges due to implant failure and comorbidities. This study reports two cases of osteoporotic pyogenic substantial bony destruction, treated cement-augmented pedicle screws (CAPS) titanium mesh cages (TMC). Both achieved complete eradication infection, spinal stabilization, favorable clinical outcomes without recurrence or during follow-up. Patient 1 underwent posterior percutaneous screw fixation...

Background: Osteoporotic vertebral fractures (OVFs) often lead to poor global sagittal alignment (GSA) and reduced quality of life (QOL). While pseudarthrosis kyphotic deformities are well-known predictors conservative treatment failure, the impact collapse, paraspinal muscle degeneration, sarcopenia, nutritional status on GSA remains unclear. This study investigated relationship between these factors in patients with conservatively treated OVFs. Methods: post hoc analysis a multicenter...

Laminoplasty is the preferred operation for most patients with cervical myelopathy due to multilevel ossification of posterior longitudinal ligament (OPLL). Recent studies have demonstrated several significant risk factors poor clinical outcomes after laminoplasty, including older age, lower preoperative Japanese Orthopaedic Association (JOA) score, postoperative change in alignment, kyphosis, and high occupying ratio OPLL (that is, greatest anteroposterior thickness diameter spinal canal at...

Retrospective single-center study.This study aimed to assess the effects of pre and postoperative teriparatide (TPTD) treatment on Hounsfield units (HU) after surgery for adult spinal deformity (ASD).The most commonly used method assessing bone mineral density is dual-energy x-ray absorptiometry. HU values at upper instrumented vertebra (UIV) have been proposed as a surrogate quality, particularly in patients with ASD. However, effect TPTD vertebral remains unclear.We identified 57...

To examine the functional role of dorsal column nuclei in neuropathic pain, electrophysiological properties low- and high-threshold neurons normal rats were examined. Single-neuronal activities recorded from gracile nucleus (GN) at 10-14 days after application four loose ligatures around sciatic nerve (chronic constriction injury; CCI). A total 190 units GN naive CCI rats. The largest population low-threshold mechanoreceptive (LTM) classified as rapidly-adapting (RA) LTM neurons, whereas...

The causative organism of vertebral osteomyelitis (VO) was almost exclusively Staphylococcus aureus. purpose this study to delineate the differences in clinical features and outcomes between patients with methicillin-resistant aureus (MRSA) methicillin-sensitive (MSSA) VO. This retrospectively reviewed 85 consecutive VO treated 2005 2011. Surgical site infections were excluded. Diagnosis made by cultures either blood or biopsied samples. We identified 16 cases MRSA 14 MSSA average follow-up...

Unloading of the proximal medial femoral cortex is usually associated with an increased bone strain at distal part prosthesis, which may cause cortical hypertrophy (CH). The objective this study was to determine factors that be considered a predisposition CH and its effect on stress shielding (SS) or durability fixation stem.A total 240 hip arthroplasties were performed between January 2006 December 2016, all hips implanted Bicontact stem. minimum follow-up period more than 2 years, mean 7.2...

Nutritional status, which is associated with osteoporosis and muscle weakness considered an important factor in the management of acute osteoporotic vertebral fracture (AOVF). However, few reports have investigated nutritional status hospitalized patients AOVF impact malnutrition on their functional prognosis. This study aimed to evaluate elderly using Controlling Status (CONUT) score determine usefulness CONUT predicting prognosis.The admission was retrospectively calculated for 134 (mean...

Background and Objectives: In this retrospective cohort study, we investigate associations between the Hounsfield units (HU) value of upper instrumented vertebra (UIV) proximal junctional kyphosis (PJK) after adult spinal deformity (ASD) surgery. Materials Methods: The consisted 60 patients (mean age 71.7 years) who underwent long fusion surgery (≥6 vertebrae) for ASD with at least 1 year follow-up. preoperative bone mineral density (BMD) measured on DXA scans, HU values UIV UIV+1,...

To examine the outcome of cervical lateral mass screw fixation focusing on analysis risk factors for screw-related complications.Ninety-four patients who underwent posterior with a total 457 screws were included in study. The placed using modified Magerl method. Computed tomographic (CT) images taken early postoperative period all patients, and trajectory angle was measured both axial sagittal plane images.In CT trajectory, 56.5 % directed within acceptable range (within 21-40° planes). As...