A5009497595- Spine and Intervertebral Disc Pathology
- Spinal Fractures and Fixation Techniques
- Scoliosis diagnosis and treatment
- Cervical and Thoracic Myelopathy
- Veterinary Oncology Research
- Osteomyelitis and Bone Disorders Research
- Spondyloarthritis Studies and Treatments
- Pelvic and Acetabular Injuries
- Infectious Diseases and Tuberculosis
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Virus-based gene therapy research
- Orthopedic Infections and Treatments
- Bone health and osteoporosis research
- Sarcoma Diagnosis and Treatment
- Cell Adhesion Molecules Research
- Medical Imaging and Analysis
- RNA Interference and Gene Delivery
- Food Allergy and Anaphylaxis Research
- MicroRNA in disease regulation
- Hip and Femur Fractures
- Musculoskeletal pain and rehabilitation
- Neuroscience and Neuropharmacology Research
- Spinal Hematomas and Complications
- Chronic Lymphocytic Leukemia Research
- NF-κB Signaling Pathways
Japanese Red Cross Society Kyoto Daini Hospital
2025
Miyoshi Kasei (Japan)
2024-2025
Hyogo University
2022-2025
Hyogo Medical University
2015-2024
Gifu University
2008-2015
Creative Commons
2015
Christie's
2015
May Institute
2015
University of California, San Francisco
2003-2014
Kumamoto University
1995-2012
A retrospective study.To assess the mechanisms and independent risk factors associated with proximal junctional kyphosis (PJK) in patients treated surgically for adult spinal deformity long fusions to sacrum.The occurrence of PJK may be related preoperative postoperative sagittal parameters. The adults are not well defined.Consecutive who underwent instrumented fusion surgery (≥6 vertebrae) sacrum a minimum 2 years follow-up were retrospectively studied. Risk included patient factors,...
Object Proximal junctional kyphosis (PJK) is a common and significant complication after corrective spinal deformity surgery. The object of this study was to compare—based on clinical outcomes, postoperative proximal rates, prevalence revision surgery—proximal thoracic (PT) distal (DT) upper instrumented vertebra (UIV) in adults who underwent spine fusion the sacrum for treatment deformity. Methods In retrospective authors evaluated radiographic data from consecutive (age > 21 years) with...
Psoriasis is a chronic inflammatory skin disease characterized by intense proliferation and abnormal differentiation of keratinocytes, although the pathogenesis still not completely clarified.We investigated mechanism keratinocyte seen in psoriasis, focusing on microRNA (miRNA).miRNAs were extracted from tissues sera atopic dermatitis healthy control. To determine pathogenic miRNAs, we performed miRNA polymerase chain reaction (PCR) array analysis. The results confirmed with quantitative...
Background Senile hemangioma, so-called cherry angioma, is known as the most common vascular anomalies specifically seen in aged skin. The pathogenesis of its abnormal angiogenesis still unclear. Methodology/Principal Findings In this study, we found that senile hemangioma consisted clusters proliferated small channels upper dermis, indicating tumor categorized a tumor. We then investigated mechanism endothelial proliferation focusing on microRNA (miRNA). miRNA PCR array analysis revealed...
The role of the bradykinin‐generating system in pathogenesis cancer was explored by simultaneously measuring plasma prekallikrein (PK), precursor kallikrein, which is major enzyme responsible for kinin generation, and kininogens (KNG), are precursors kinin, patients with various cancers. mean value PK healthy volunteers 2.5 ± 0.5 (mean SD) units/mg protein that (all stage IV) 1.7 0.7 units/ mg protein. KNG 12.5 2.0 ng equivalents/mg 10.9 2,8 ng. These data showed values were significantly...
Postoperative C-5 palsy is known as a common complication after cervical laminoplasty. The authors of this article have encountered postoperative more often when laminoplasty was combined with instrumented posterior spinal fusion than it performed alone. purpose clinical study to examine the incidence fifth nerve root (C-5 palsy) and surgical results in patients myelopathy who had undergone or without fusion.The retrospectively studied fusion.Clinical data on 58 were evaluated analyzed....
Abstract Pyogenic spondylitis in older patients with osteoporosis presents significant challenges due to implant failure and comorbidities. This study reports two cases of osteoporotic pyogenic substantial bony destruction, treated cement-augmented pedicle screws (CAPS) titanium mesh cages (TMC). Both achieved complete eradication infection, spinal stabilization, favorable clinical outcomes without recurrence or during follow-up. Patient 1 underwent posterior percutaneous screw fixation...
High molecular weight DNAs prepared from a variety of human tumors maintained in nude mice were assayed for their ability to transform NIH 3T3 cells. 4 21 tested induced transformed foci cultures They Ewing sarcoma line, glioblastoma leiomyosarcoma and lung carcinoma line. Hybridization analyses the transformant with repetitive sequence as probe revealed that four distinct transforming DNA sequences transferred cells tumor lines. The line was homologue oncogene Kirsten murine virus (Ki-ras)....
The present study examined noradrenaline-induced modulation of ATP-evoked currents in dorsal root ganglion (DRG) neurons after sciatic nerve injury (transection). ATP (10 μM) generated fast/mixed type whole-cell membrane currents, possibly as mediated via P2X3/P2X3-like receptors, and slow the P2X2/3 acutely dissociated L4/5 DRG neurons, without significant difference between sham group. For group, noradrenaline enhanced ipsilateral that is not inhibited by H-7, a broad inhibitor protein...
MicroRNAs (miRNAs) are post-transcriptional regulators that bind to complementary sequences in the 3' UTRs of mRNAs, leading gene silencing, and their serum levels can be useful biomarkers for diagnosis, prognosis therapeutic value various diseases. Although miRNAs thought involved pathogenesis human diseases, little is known about psoriasis. Recently, psoriasis has attracted attention its characteristics as a Th17 disease; expression IL-17 increased lesional skin serum. We hypothesized...
Malignant melanoma (MM) is one of the most aggressive cancers in dogs and humans. However, molecular mechanisms its development progression remain unclear. Presently, we examined expression profile microRNAs (miRs) canine oral MM tissues paired normal mucosa by using microRNA-microarray assay quantitative RT-PCR. Importantly, a decreased miR-203 was significantly associated with shorter survival time. Also, -205 were markedly down-regulated human cell lines tested. Furthermore, ectopic...
Hughes-Stovin syndrome (HSS) is an exceedingly rare disease characterized by thrombotic phlebitis and pulmonary or bronchial artery aneurysms. A 68-year-old man presented with ischemic colitis, angiography revealed occlusion of the inferior mesenteric vein arteriovenous malformation in region. Medical treatment was unsuccessful, a left hemicolectomy therefore performed following coil embolization. Subsequently, aneurysm incidentally detected, embolization performed. However, patient...
KIT, a transmembrane receptor tyrosine kinase, is one of the specific targets for anti‐cancer therapy. In humans, its expression and mutations have been identified in malignant melanomas therapies using molecular‐targeted agents promising these tumours. As human melanoma, canine melanoma fatal disease with metastases poor response has observed all standard protocols. our study, KIT exon 11 dogs histologically confirmed oral were evaluated. Although 20 39 cases positive protein, there was no...
Laminoplasty is the preferred operation for most patients with cervical myelopathy due to multilevel ossification of posterior longitudinal ligament (OPLL). Recent studies have demonstrated several significant risk factors poor clinical outcomes after laminoplasty, including older age, lower preoperative Japanese Orthopaedic Association (JOA) score, postoperative change in alignment, kyphosis, and high occupying ratio OPLL (that is, greatest anteroposterior thickness diameter spinal canal at...
Nutritional status, which is associated with osteoporosis and muscle weakness considered an important factor in the management of acute osteoporotic vertebral fracture (AOVF). However, few reports have investigated nutritional status hospitalized patients AOVF impact malnutrition on their functional prognosis. This study aimed to evaluate elderly using Controlling Status (CONUT) score determine usefulness CONUT predicting prognosis.The admission was retrospectively calculated for 134 (mean...