A5089435485- Gastroesophageal reflux and treatments
- Esophageal and GI Pathology
- Eosinophilic Esophagitis
- Dysphagia Assessment and Management
- Helicobacter pylori-related gastroenterology studies
- Gastric Cancer Management and Outcomes
- Gastrointestinal disorders and treatments
- Veterinary medicine and infectious diseases
- Biliary and Gastrointestinal Fistulas
- Liver Disease Diagnosis and Treatment
- Abdominal vascular conditions and treatments
- Esophageal Cancer Research and Treatment
- Gastrointestinal Tumor Research and Treatment
- Gallbladder and Bile Duct Disorders
- Vascular anomalies and interventions
- Global Health Care Issues
- Infectious Encephalopathies and Encephalitis
- Gastrointestinal Bleeding Diagnosis and Treatment
- Stuttering Research and Treatment
- Hepatitis Viruses Studies and Epidemiology
- Gastrointestinal motility and disorders
- Hepatitis B Virus Studies
- SARS-CoV-2 and COVID-19 Research
- Pediatric Hepatobiliary Diseases and Treatments
- Insurance, Mortality, Demography, Risk Management
Tehran University of Medical Sciences
2009-2022
Shariati Hospital
2000-2022
Qom University of Medical Science and Health Services
2021
Digestive Health Research Institute
2015
Digestive Disease Research Institute
2015
GTx (United States)
2011
University of Tehran
2002-2011
Università Campus Bio-Medico
2009
Centre International de Recherche sur le Cancer
2009
King's College London
2009
Ardabil Province, in northwestern Iran, has the highest rate of gastric (predominantly cardia) adenocarcinoma Iran. This study aimed to investigate feasibility endoscopic screening and look for associated Helicobacter pylori infection precancerous lesions.
Background: Therapeutic options for achalasia include pharmacological therapy, surgical myotomy, pneumatic dilatation and intrasphincteric botulinum toxin injection. Aim: To compare injection with in a randomized trial. Patients/methods: Forty adults newly diagnosed were to receive ( n =20) or =20). Symptom scores evaluated at 1, 6 12 months. Clinical relapse was defined as symptom score greater than 50% of baseline. Relapsers received second dilatation. Results: The cumulative 12‐month...
Pneumatic dilatation is considered to be the first line therapy for achalasia, but long-term outcome studies are scarce and limited by their retrospective design. There also no consensus on optimal method performing pneumatic dilation as regard balloon diameter, amount rate inflation pressure.To address these questions in a large prospective study.Over period of 10 years 262 achalasia patients referred our centre were enrolled. All underwent pre-treatment clinical evaluation followed every 6...
Summary Background Pneumatic dilatation is the first line therapy in achalasia, but half of patients relapse within 5 years and require further dilatations. Aim To assess whether botulinum toxin injection before pneumatic superior to alone achalasia patients. Methods Newly diagnosed were randomly assigned receive 1 month (botulinum toxin‐pneumatic group: 27 with median age 38) or undergo (pneumatic 30). Response was assessed by clinical objective methods at various intervals. Results...
Goals To evaluate the effects of probucol, an agent with strong antioxidant properties, in reversing biochemical changes nonalcoholic steatohepatitis (NASH). Background There is currently no well-established medical treatment NASH. It believed that oxidative stress plays a major role hepatic damage these patients. Study Cases biopsy-proven NASH referring to referral center Tehran during 12-month period were included study. Viral, autoimmune and other diseases excluded. Alcohol ingestion was...
Abstract Background: In Iran, there is insufficient information on the efficacy of Helicobacter pylori eradication regimens shorter than 10 days. This study aims at assessing 4‐ and 7‐day H. in a high‐incidence area gastric cancer Iran. Methods: Subjects with an endoscopic diagnosis gastritis, positive urease test, histological chronic gastritis were enrolled. Patients randomly assigned to one three groups: AOC7 (1000 mg amoxicillin, 20 omeprazole, 500 clarithromycin twice daily for 7 days),...
BACKGROUND Although Heller myotomy is one of the most effective treatments for achalasia, it may be associated with early or late symptom relapse in some patients. Therefore, additional treatment required to achieve better control symptoms.To evaluate safety and efficacy pneumatic balloon dilation (PBD) patients after myotomy. METHODS Thirty six post-myotomy were evaluated from 1993 2013. Six excluded analysis because comorbid diseases epiphrenic diverticula. treated PBD. Primary outcome was...
Furazolidone is a much cheaper drug with very low resistance against Helicobacter pylori compared to clarithromycin. We aim evaluate safety and efficacy of sequential furazolidone-based regimen versus clarithromycin-based therapy in H. eradication for ulcer disease.Patients proven peptic or duodenitis were randomized into three groups: OAB-M-F; metronidazole (M) (500 mg bid) the first 5 days, followed by furazolidone (F) (200 second days; OAC-P; clarithromycin (C) 10 OAB-C-F; days days. All...
Abstract Background Achalasia is a well-characterized esophageal motor disorder but the rarity of disease limits performing large studies on its demographic and clinical features. Methods Prospectively, 213 achalasia patients (110 men 103 women) were enrolled in study. The diagnosis established by clinical, radiographic, endoscopic as well manometry criteria. All underwent pre-designed evaluation before within 6 months after treatment. Results Solid dysphagia was most common symptom women....
Idiopathic achalasia (IA) is a chronic disease without definite therapy. Ethanolamine oleate (EO) has multiple biological effects, including inflammatory activities. We investigated the efficacy of EO injection in selected patients with IA.One hundred and thirty-six IA were evaluated prospectively. 13 that are resistant to or poor candidate pneumatic balloon dilation and/or cardiomyotomy at Digestive Disease Research Center, Shariati Hospital, Tehran, as major referral center for Iran an...
Abstract Objectives Achalasia is an esophageal motor disorder characterized by aperistalsis and incomplete relaxation of the lower sphincter (LES). The meaningful correlation between LES pressure severity clinical symptoms uncertain. aim this study was to elucidate scoring pressure. Methods Over a 4-yr period from 1997 2001, all newly diagnosed patients with idiopathic achalasia were consecutively enrolled in study. Diagnosis established based on clinical, radiographic, endoscopic,...
Achalasia is an esophageal motor disorder characterized by aperistalsis and incomplete relaxation of the lower sphincter (LES). The meaningful correlation between LES pressure severity clinical symptoms uncertain. aim this study was to elucidate scoring pressure.Over a 4-yr period from 1997 2001, all newly diagnosed patients with idiopathic achalasia were consecutively enrolled in study. Diagnosis established based on clinical, radiographic, endoscopic, manometric criteria. five cardinal...
Graded pneumatic dilatation (PD) is an appropriate long-term therapy and botulinum toxin injection (BT) a relatively short-term in idiopathic achalasia. Their combination has not been previously scrutinized. This study aimed to evaluate the role of BT enhancing efficacy PD with 30 mm balloons. Patients who underwent balloons after injections group age- sex-matched controls were treated only enrolled study. Symptom scores taken before, 1 month then every 3 months PD. There no significant...
Idiopathic achalasia (IA) is a primary motor disorder of the esophagus. Recently, ethanolamine oleate (EO) has been introduced as novel therapy in IA. We investigate long-term efficacy EO injection selected IA patients. Two hundred twenty patients with were evaluated prospectively. Thirty-one who resistant to or poor candidate pneumatic balloon dilation and/or cardiomyotomy enrolled this study. was injected into lower esophageal sphincter three times at 2-week intervals. Patients symptom...
After a hiatus of 30 years an attempt is now being made to re-assess the previously reported very high esophageal cancer incidence rates in Caspian Littoral. The extraordinarily found eastern side Littoral, were re-confirmed five ago for Turkoman region, using balloon cytology supplemented by esophagoscopy suspected cases. focus this time was on Ardabil province western where moderately high. A pilot chromoendoscopic screening program scheduled 650 asymptomatic adults from randomly selected...
Summary Background: The non‐invasive assessment of primary achalasia is not precise. Aim: To compare investigations before and 1 month after balloon dilation in achalasia. Methods: Fifty‐two patients with were enrolled. Subjective objective variables oesophageal functions analysed dilation. Results: mean predilation symptom score, lower sphincter pressure, height volume barium at 5 min 7.7 ± 2.6, 62.0 25.1 mmHg, 9.2 6.1 cm 53.2 49.8 mL respectively; the postdilation values 3.0 3.0, 34.1 12.5...
Objective Subjective assessment of primary achalasia is not accurate. We aimed to study the utility surface area barium retention in objective these patients. Methods and esophageal functions 99 patients with were evaluated initially 43 them reevaluated 1 month after balloon dilation. Results Before dilation: Ninety-nine enrolled. Forty-one male. The mean age was 37.5±15.3 years. score, resting lower sphincter pressure, height, volume at 5 min 8.03±3.1, 59.1±20 mmHg, 9.9±4.9 cm, 23.6±13.9...
BACKGROUND Achalasia, as an incurable disease is defined by the lack of normal esophageal peristalsis and loss lower sphincter relaxation due to impaired myenteric neural plexus. The exact cause cells degeneration in achalasia still unknown. One hypothesis that certain neurotropic viruses autoimmune factors inflammatory response network, which consequently destroy cells. This study was designed find evidence viral causes achalasia. METHODS In this case-control study, 52 patients with 50...
BACKGROUND Achalasia is the most well known esophageal motility disorder. Laparoscopic Heller myotomy (LHM) effective treatment for achalasia. The aim of this study was to review our results on LHM METHODS In cross-sectional all patients undergoing between 2015 and 2017 were studied. followed by an anterior or posterior partial fundoplication. All up at least six months. RESULTS We conducted prospective 36 consecutive who underwent over 3 years. mean age 36.64 ± 13.47 30 (83.3%) Toupet 6...