A5050883582- HIV/AIDS drug development and treatment
- HIV/AIDS Research and Interventions
- Antibiotics Pharmacokinetics and Efficacy
- Pregnancy and Medication Impact
- Inflammasome and immune disorders
- Pharmacological Effects and Toxicity Studies
- HIV Research and Treatment
- Chronic Lymphocytic Leukemia Research
- Antifungal resistance and susceptibility
- Pharmaceutical studies and practices
- Pneumocystis jirovecii pneumonia detection and treatment
- Cardiac Ischemia and Reperfusion
- Intramuscular injections and effects
- interferon and immune responses
- Biomedical and Engineering Education
- Autoimmune and Inflammatory Disorders
- Lung Cancer Treatments and Mutations
- Autoimmune and Inflammatory Disorders Research
- Gout, Hyperuricemia, Uric Acid
- Colorectal Cancer Treatments and Studies
- Antimicrobial Resistance in Staphylococcus
- Infectious Aortic and Vascular Conditions
- Immunodeficiency and Autoimmune Disorders
- Quality and Safety in Healthcare
- Maternal Mental Health During Pregnancy and Postpartum
Assistance Publique – Hôpitaux de Paris
2015-2024
Hôpitaux Universitaires Henri-Mondor
2019-2024
Inserm
2022-2024
Institut Mondor de Recherche Biomédicale
2022-2024
Université Paris-Est Créteil
2020-2024
École Nationale Vétérinaire d'Alfort
2022-2024
Centre Hospitalier Universitaire Henri-Mondor
2019-2021
GTx (United States)
2021
Hôpital Albert-Chenevier
2019
Saint Louis University Hospital
2018
Abstract The paradigm type I interferonopathy Aicardi-Goutières syndrome (AGS) is most typically characterized by severe neurological involvement. AGS considered an immune-mediated disease, poorly responsive to conventional immunosuppression. Premised on a chronic enhancement of interferon signaling, JAK1/2 inhibition has been trialed in AGS, with clear improvements cutaneous and systemic disease manifestations. Contrastingly, treatment efficacy at the level system less conclusive. Here, we...
Background: A sensitive liquid chromatography coupled with tandem mass spectrometry (MS/MS) method for the analysis in a small volume of plasma 14 tyrosine kinase inhibitors currently used (imatinib, dasatinib, ibrutinib, ponatinib, trametinib, sunitinib, cobimetinib, dabrafenib, erlotinib, lapatinib, nilotinib, bosutinib, sorafenib, and vemurafenib) has been developed validated. This multianalyte MS/MS assay is interest anticancer drug combination therapy. Methods: After simple protein...
AIMS Pregnant women can be exposed to numerous drugs during the gestational period. For obvious ethical reasons, in vivo studies of fetal exposure are limited. Information about transplacental transfer prior their administration pregnant would highly useful. In present study, a novel approach was developed quantitatively predict or administered mother quantitatively. Methods Transplacental parameters estimated from ex human placenta perfusion experiments were implemented...
A simple, rapid, and sensitive liquid chromatography coupled with tandem mass spectrometry method has been developed validated for the quantification of ruxolitinib, olaparib, vismodegib, pazopanib in human plasma.After a simple protein precipitation plasma samples, chromatographic separation was performed using an ultraperformance system positive ionization mode. The mobile phase consisted gradient elution 10-mmol/L formate ammonium buffer containing 0.1% (vol/vol) formic acid (phase A)...
In Schnitzler syndrome, which is mostly diagnosed with a low and asymptomatic monoclonal peak, anakinra has always exhibited complete but only transient control of the auto-inflammatory signs, are induced by interleukin (IL)-1 auto-activation. We focused on treatment case syndrome moderate macroglobulinemia peak. Anakinra failed to improve severe inflammatory anaemia dysglobulinemia, rituximab-dexamethasone-cyclophosphamide chemotherapy alone allowed response. The correlation between...
ABSTRACT The aims of this study were to describe the unbound and total lopinavir (LPV) pharmacokinetics in pregnant women order evaluate if a dosing adjustment is necessary during pregnancy. Lopinavir placental transfer described, several genetic covariates tested explain its variability. A 400 maternal, 79 cord blood, 48 amniotic fluid samples collected from 208 for LPV concentration determinations analysis. Among maternal concentrations, also used measure concentrations. Population models...
Adjusting drug therapy under veno-venous extracorporeal membrane oxygenation (VV ECMO) is challenging. Although impaired pharmacokinetics (PK) VV ECMO have been reported for sedative drugs and antibiotics, data about amiodarone are lacking. We evaluated the of both in vitro vivo.
Aims This prospective study aimed to develop a population pharmacokinetics (PK) model of hydroxyurea (HU) in patients with sickle cell disease. can be used determine the impact glomerular filtration rate (GFR) on HU kinetics. Methods We included 30 patients. They underwent analyses plasma and urine. Six PK 2 periods without angiotensin‐converting enzyme inhibitor. was assayed validated high‐performance liquid chromatography‐UV method. Noncompartmental analysis conducted built Monolix....
Mitochondrial permeability transition pore (mPTP) opening is critical for mediating cell death during hepatic ischaemia-reperfusion injury (IRI). Blocking mPTP by inhibiting cyclophilin D (CypD) a promising pharmacological approach the treatment of IRI. Here, we show that diastereoisomers new class small-molecule inhibitors (SMCypIs) have properties make them attractive candidates development therapeutic agents against liver IRI.Derivatives parent SMCypI were synthesised and evaluated their...
The weaker diffusion of echinocandins in the peritoneal fluid (PF) could promote
A clinical study was conduct in HIV-infected children to evaluate the prophylactic doses of cotrimoxazole [sulfamethoxazole (SMX) and trimethoprim (TMP)] advised by WHO.Children received lopinavir-based antiretroviral therapy with prophylaxis (200 mg SMX/40 TMP once daily). nonlinear mixed effects modelling approach used analyse plasma concentrations. Factors that could impact pharmacokinetic profile were investigated. The model subsequently simulate individual exposure different...
Veno-arterial extracorporeal membrane oxygenation (V-A ECMO) support leads to complex pharmacokinetic alterations, whereas adequate drug dosing is paramount for efficacy and absence of toxicity in critically ill patients. Amikacin a major antibiotic used nosocomial sepsis, especially these We aimed describe amikacin pharmacokinetics on V-A ECMO determine relevant variables improve its dosing. All patients requiring empirical antimicrobial therapy, including sepsis supported or not by ECMO,...
Objective: This study aimed to analyze the outcomes and challenges associated with surgical redo procedures following aortic valve replacement for acute infective endocarditis. While transcatheter implantation is growing in terms of its utilization degenerative bioprostheses failure, valve-in-valve are limited Surgical interventions prosthesis endocarditis carry a significant risk, higher mortality morbidity, often requiring concomitant complex procedures. Methods: was retrospective,...
The MONOD ANRS 12206 trial was designated to assess simplification of a successful lopinavir (LPV)-based antiretroviral treatment in HIV-infected children younger than 3 years age using efavirenz (EFV; 25 mg/kg body weight/day) preserve the class protease inhibitors for that group. In this substudy, EFV concentrations were measured check consistency an dose and compare it with 2016 FDA recommended dose. Fifty-two underwent blood sampling pharmacokinetic study at 6 months 12 after switching...
The OPTIPRIM-ANRS 147 trial compared intensive combination ART (darunavir/ritonavir, tenofovir disoproxil fumarate/emtricitabine, raltegravir and maraviroc) started early during primary HIV-1 infection with standard tritherapy darunavir/ritonavir, fumarate emtricitabine. From month 6 to 18, the percentage of viral load values <50 copies/mL was lower in pentatherapy arm than arm. Here we antiretroviral drug concentrations between two arms.Plasma samples were collected from 50 patients at...
The medical and university department of biology pathology at Henri Mondor hospital in Creteil has been engaged an NF EN ISO 15189 accreditation process since 2014. One the elements this concerns quality handling samples their transportation to laboratories, including implementation place requires fighting against pre-examination non-conformities, which are source many dysfunctions. group implemented several actions a targeted care service. Thanks these, rate non-conformities halved 18...