A5023217276- Hemoglobinopathies and Related Disorders
- Renal Transplantation Outcomes and Treatments
- Antibiotics Pharmacokinetics and Efficacy
- Pneumocystis jirovecii pneumonia detection and treatment
- Liver Disease and Transplantation
- Pharmacological Effects and Toxicity Studies
- Antifungal resistance and susceptibility
- Iron Metabolism and Disorders
- Hepatocellular Carcinoma Treatment and Prognosis
- Cancer Treatment and Pharmacology
- HIV/AIDS drug development and treatment
- Signaling Pathways in Disease
- Colorectal Cancer Treatments and Studies
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Liver Disease Diagnosis and Treatment
- Blood groups and transfusion
- PI3K/AKT/mTOR signaling in cancer
- Chronic Myeloid Leukemia Treatments
- Biochemical and Molecular Research
- Chronic Lymphocytic Leukemia Research
- Antibiotic Resistance in Bacteria
- Pneumonia and Respiratory Infections
- Antimicrobial Resistance in Staphylococcus
- Inflammasome and immune disorders
- Hepatitis C virus research
Assistance Publique – Hôpitaux de Paris
2016-2025
Université Paris-Est Créteil
2013-2025
Hôpitaux Universitaires Henri-Mondor
2015-2024
Inserm
2002-2023
Institut Mondor de Recherche Biomédicale
2022-2023
École Nationale Vétérinaire d'Alfort
2023
Centre Hospitalier Universitaire Henri-Mondor
2007-2022
Institut Pasteur
2021-2022
GERCOR (France)
2022
Early detection of Colon Cancer using Molecular Markers and Microbiota
2019
HIV-1 infection is characterized by a chronic activation of the immune system and suppressed function T lymphocytes. Regulatory CD4+ CD25high FoxP3+CD127low cells (Treg) play key role in both conditions. Here, we show that positive patients have significant increase Treg-associated expression CD39/ENTPD1, an ectoenzyme which concert with CD73 generates adenosine. We vitro CD39/adenosine axis involved Treg suppression HIV infection. inhibitory effects are relieved CD39 down modulation...
Abstract The paradigm type I interferonopathy Aicardi-Goutières syndrome (AGS) is most typically characterized by severe neurological involvement. AGS considered an immune-mediated disease, poorly responsive to conventional immunosuppression. Premised on a chronic enhancement of interferon signaling, JAK1/2 inhibition has been trialed in AGS, with clear improvements cutaneous and systemic disease manifestations. Contrastingly, treatment efficacy at the level system less conclusive. Here, we...
The mechanisms by which Regulatory T cells suppress IL-2 production of effector CD4+ in pathological conditions are unclear. A subpopulation human Treg expresses the ectoenzyme CD39, association with CD73 converts ATP/ADP/AMP to adenosine. We show here that Treg/CD39+ expression activated T-cells more efficiently than Treg/CD39−. This inhibition is due demethylation an essential CpG site il-2 gene promoter, was reversed anti-CD39 mAb. By recapitulating events downstream CD39/adenosine...
A simple and rapid ultra-high-performance liquid chromatography (UHPLC) method using UV detection was developed for the simultaneous determination of eight β-lactam antibiotics in human plasma, including four penicillins, amoxicillin (AMX), cloxacillin (CLX), oxacillin (OXA), piperacillin (PIP), cephalosporins, cefazolin (CFZ), cefepime (FEP), cefotaxime (CTX), ceftazidime (CAZ). One hundred-microliter samples were spiked with thiopental as an internal standard, proteins precipitated by...
Abstract Background Bone marrow -derived cells (BMDCs) can either limit or contribute to the process of pulmonary vascular remodeling. Whether difference in their effects depends on mechanism hypertension (PH) remains unknown. Objectives We investigated effect BMDCs PH induced mice by monocrotaline exposure chronic hypoxia. Methods Intravenous administration active metabolite (monocrotaline pyrrole, MCTp) C57BL/6 within 15 days, due remodeling small distal vessels. Three days after MCTp...
Invasive candidiasis, including intra-abdominal candidiasis (IAC), is a common complication after liver transplantation. Antifungal drugs such as echinocandins and fluconazole (FCZ) are frequently used to prevent or treat fungal infections. The diffusion of these antifungals within abdominal body sites has been rarely reported, in particular, transplant recipients. This study aimed evaluate the biliary caspofungin (CAS) FCZ. CAS FCZ concentrations were determined plasma bile using validated...
Many factors are involved in the appropriate use of aminoglycosides, such as modalities administration, drug levels monitoring and duration treatment. We assessed prospectively impact an antibiotic control team on appropriateness prescriptions.After a first observational audit assessing prescriptions, issuing updated recommendations, we performed interventional audit, where provided counselling when prescriptions were considered inappropriate. Appropriateness clinical outcomes patients...
Abstract Background Hydroxyurea (HU) is the first approved pharmacological treatment of sickle cell anemia (SCA). The objectives this study were to develop population pharmacokinetic(PK)-pharmacodynamic(PD) models for HU in order characterize exposure-efficacy relationships and their variability, compare two dosing regimens by simulations some recommendations monitoring treatment. Methods built using modelling software NONMEM VII based on data from clinical studies SCA adult patients...
During the early post-transplantation period, limitations of monitoring current tacrolimus dose with classic pharmacokinetics (PK) have been demonstrated in liver-transplant recipients. Evaluation pharmacodynamics (PD) using calcineurin activity (CNA) has proposed to optimize dosing. The aim present study was determine time maximal inhibition CNA, explore relation between exposure and analyze its variability. Blood drawn from 14 patients 0, 2, 3, 4, 6, 9 hours after intake on days 8, 21, 90...
Recent publications suggest potential benefits from statins as a preventive or adjuvant therapy in sepsis. Whether ongoing statin should be continued discontinued patients admitted the intensive care unit (ICU) for sepsis is open to question.We retrospectively compared with severe and septic shock whom had been continued. The primary endpoint was number of organ failure-free days at day 14. Secondary end-points included hospital mortality safety. association continuation outcome evaluated...