A5037129983- Cholinesterase and Neurodegenerative Diseases
- Mycotoxins in Agriculture and Food
- Pesticide Exposure and Toxicity
- Insect and Pesticide Research
- Computational Drug Discovery Methods
- Polyamine Metabolism and Applications
- Carcinogens and Genotoxicity Assessment
- Probiotics and Fermented Foods
- Environmental Toxicology and Ecotoxicology
- Ruminant Nutrition and Digestive Physiology
- Plant Disease Resistance and Genetics
- Plant Pathogens and Fungal Diseases
- Chemical synthesis and alkaloids
- Spectroscopy and Chemometric Analyses
- Wheat and Barley Genetics and Pathology
- Analytical Chemistry and Chromatography
- Chemical Reaction Mechanisms
- Microfluidic and Capillary Electrophoresis Applications
- Plant and fungal interactions
- Indoor Air Quality and Microbial Exposure
- Plant Pathogens and Resistance
- Protein Hydrolysis and Bioactive Peptides
- Pesticide and Herbicide Environmental Studies
- Botany and Plant Ecology Studies
- Botanical Research and Chemistry
Jan Evangelista Purkyně University in Ústí nad Labem
2006-2023
University of Hradec Králové
2012-2018
Bentham Science Publishers (United Arab Emirates)
2013
Bentham Science Publishers (China)
2013
Mendel University in Brno
2005-2011
University Hospital Hradec Králové
2010
University of Defence
2007-2010
Inje University
2010
Masaryk University
1999-2006
Jan Evangelista Purkyně Military Medical Academy
2004
Aflatoxins are cancerogenic compounds produced predominantly by certain strains of the Aspergillus genus. The ideal solution for minimization health risk that aflatoxins pose is prevention foods and feeds contamination. Unfortunately, these contaminants can never be completely removed, on account, many studies have been carried out to explore an effective process their detoxification a threshold level. Biological decontamination seems attractive because it works under mild, environmentally...
Trichothecenes are a group of mycotoxins mainly produced by the fungi Fusarium genus. Consumers particularly concerned over toxicity and food safety trichothecenes their metabolites from food-producing animals. The metabolism T-2 toxin, deoxynivalenol (DON), nivalenol (NIV), fusarenon-X (FX), diacetoxyscirpenol (DAS), 3-acetyldeoxy-nivalenol (3-aDON), 15-acetyldeoxynivalenol (15-aDON) in rodents, swine, ruminants, poultry, humans reviewed this article. Metabolic pathways these very...
Six AChE monooxime-monocarbamoyl reactivators with an (E)-but-2-ene linker were synthesized using modification of currently known synthetic pathways. Their potency to reactivate inhibited by the nerve agent tabun and insecticide paraoxon was tested in vitro. The reactivation efficacies pralidoxime, HI-6, obidoxime, K048, K075 newly prepared compared. According results obtained, one reactivator seems be promising against tabun-inhibited two paraoxon-inhibited AChE. best obtained for...
The issue of moulds and, thus, contamination with mycotoxins is very topical, particularly in connexion forages from grass stands used at the end growing season. Deoxynivalenol (DON), zearalenone (ZEA), fumonisins (FUM) and aflatoxins (AFL) are among most common mycotoxins. aim paper was to determine concentrations selected grasses (Lolium perenne, Festulolium pabulare, braunii) their mixtures Festuca rubra an/or Poa pratensis during season as a marker safety, which assessed according...
Nine potential AChE reactivators were synthesized using a modification of currently known synthetic pathways. Their potency to reactivate inhibited by insecticide chlorpyrifos was tested in vitro. 2,2′-Bis(hydroxyiminomethyl)-1,1′-(1,4-phenylenedimethyl)-bispyridinium dibromide seems be the most potent reactivator. The reactivation these compounds depends on structural factors such as length linking chain between both pyridinium rings and position oxime moiety ring.
Nine potential non-symmetrical xylene-bridged AChE reactivators were synthesized using modifications of currently known synthetic pathways. Their potency to reactivate inhibited by the nerve agent tabun and insecticide paraoxon together with nine symmetrical compounds, was tested in vitro. Seven compounds promising against paraoxon-inhibited AChE. Two found be more potent tabun-inhibited than obidoxime at a concentration applicable vivo.
Acetylcholinesterase (AChE) reactivators are crucial antidotes to organophosphate intoxication. A new series of 26 monooxime-monocarbamoyl xylene-linked bispyridinium compounds was prepared and tested in vitro, along with known (pralidoxime, HI-6, obidoxime, trimedoxime, methoxime, K107, K108 K203), on a model tabun- paraoxon-, methylparaoxon- DFP-inhibited human erythrocyte AChE. Although their ability reactivate tabun-inhibited AChE did not exceed that the previously compounds, some newly...