A5062262842- Traumatic Brain Injury and Neurovascular Disturbances
- Viral Infections and Outbreaks Research
- Disaster Response and Management
- Cerebrospinal fluid and hydrocephalus
- Traumatic Brain Injury Research
- Infective Endocarditis Diagnosis and Management
- Health and Conflict Studies
- Streptococcal Infections and Treatments
- Hemodynamic Monitoring and Therapy
- Viral Infections and Vectors
- Trauma and Emergency Care Studies
- Cardiac Structural Anomalies and Repair
- Thermal Regulation in Medicine
- Cardiac Valve Diseases and Treatments
- Intracranial Aneurysms: Treatment and Complications
- Venous Thromboembolism Diagnosis and Management
- COVID-19 epidemiological studies
- Advanced MRI Techniques and Applications
- Hepatitis B Virus Studies
- Acute Myocardial Infarction Research
- COVID-19 and healthcare impacts
- Central Venous Catheters and Hemodialysis
- Respiratory Support and Mechanisms
- Intensive Care Unit Cognitive Disorders
- Cardiac Arrhythmias and Treatments
Associazione Italiana Vulvodinia Onlus
2021-2025
International Rescue Committee
2015-2024
EMERGENCY
2021-2024
Centre for Sight
2023-2024
International Flame Research Foundation
2021-2022
Kabul University
2022
National Centre for Research
2022
Ministry of Health and Sanitation
2015
Virginia Commonwealth University Medical Center
2000-2006
Azienda Ospedaliera San Gerardo
1998-2005
Object The edema associated with brain swelling after traumatic injury (TBI) has been thought to be vasogenic in origin, but the results of previous laboratory studies by authors have shown that a cellular form is mainly responsible for TBI. In this study used magnetic resonance (MR) imaging techniques identify type occurs patients Methods Diffusion-weighted MR was evaluate apparent diffusion coefficient (ADC) 44 TBI (Glasgow Coma Scale Score < 8) and eight healthy volunteers. Higher ADC...
Object The goal of this study was to demonstrate the posttraumatic neurochemical damage in normal-appearing brain and assess mitochondrial dysfunction by measuring N-acetylaspartate (NAA) levels patients with severe head injuries, using proton ( 1 H) magnetic resonance (MR) spectroscopy. Methods Semiquantitative analysis NAA relative creatine-containing compounds (Cr) choline (Cho) carried out from spectra obtained means chemical shift (CS) imaging single-voxel (SV) methods 25 traumatic...
Infection with Ebola virus (EBOV) results in a life-threatening disease, reported mortality rates between 50%-70%. The factors that determine patient survival are poorly understood; however, clinical observations indicate EBOV viremia may be associated fatal outcome. We conducted study of the kinetics Zaire patients disease (EVD) who were managed at an Treatment Centre Sierra Leone during recent West African outbreak.Data from 84 EVD (38 survivors, 46 nonsurvivors) analyzed, and was...
Ebola virus (EBOV) infection is characterized by an excessive inflammatory response, a loss of lymphocytes and general paralysis the immune system, however pathophysiological mechanisms are not fully understood. In cohort 23 fatal 21 survivors ebola disease (EVD) cases admitted to Emergency Ebola-Treatment-Center in Goderich (Freetown, Sierra Leone) during 2014 2016 EBOV epidemic Western Africa, we analyzed pathway-focused gene expression profile secreted proteins involved response levels...
Background Traumatic brain injuries (TBIs) are a common cause of morbidity and mortality in war zones. Currently, the vast majority reports on war-related TBIs concern soldiers, little is known about this condition civilians. Methods This retrospective observational study from EMERGENCY NGO hospital for civilian victims Kabul, Afghanistan. Data were gathered all adults children with admitted between June November 2021. The aims to describe epidemiology clinical patterns patients non-military...
Having determined that edema and not vascular engorgement is the major factor leading to traumatic brain swelling, objective of this study was determine which type edema, cellular or vasogenic, responsible for increased tissue water in patients with focal lesions. Severely head injured (GCS 8 less) were transported imaging suites measurement apparent diffusion coefficient (ADC) using magnetic resonance technique. Cerebral blood flow by stable Xenon method also measured regions interest....
We investigate the impact on outcome of different levels supportive treatment in Ebola virus disease (EVD). The NGO EMERGENCY delivered care sequentially at two Treatment Centres (ETC) Sierra Leone: first Lakka (fluids, symptomatic, antibiotic, antimalaria treatment, and hospital level medical care), thereafter Goderich, adding organ support only African ETC with an equipped staffed intensive unit (ETC-ICU).The primary this retrospective cohort study was in-ETC mortality. Secondarily, we...
Despite the large burden of critically ill patients in developing countries, mechanical ventilation (MV) is scarce these low-resource settings. In absence data, issues like costs and lack training are often felt to outweigh benefits potential MV implementation such places. We aimed investigate impact feasibility a surgical ICU West Africa.
Pregnancy and childbirth on anticoagulants after mechanical heart valve replacement present a high risk of complications for both mother baby. On top pregnancy worsening the mother's cardiac function, anticoagulant therapy itself is crucial problem. A safe effective anticoagulation regimen fetus not possible. The most drugs preventing thrombosis are VKAs, whose dosage needs to be adjusted with frequent INR checks. Moreover, VKAs can have embryopathic teratogenic action. Patients in follow-up...
The coronavirus disease (COVID-19) pandemic represented an unprecedented challenge for health care facilities, and innovative solutions were urgently required to overcome the high volume of critically ill infectious patients, limit in-hospital outbreaks, risk occupational infection workers (HCWs). Bergamo was hardest-hit Italian province by COVID-19, local system had undergo a profound prompt reorganization. A COVID-19-only field hospital rapidly set up meeting standards severe acute...
Pathogenesis of Ebola virus disease remains poorly understood. We used concomitant determination routine laboratory biomarkers and viremia to explore the potential role viral replication in specific organ damage.We recruited patients with detectable admitted EMERGENCY Organizzazione Non Governativa Lucrativa di Utilità Sociale (ONG ONLUS) Treatment Center Sierra Leone. Repeated measure viremia, alanine aminotransferase (ALT), aspartate (AST), bilirubin, creatine phosphokinase (CPK), lactate...
Rheumatic heart disease is endemic in Sub-Saharan Africa and while efforts are under way to boost prophylaxis early diagnosis, access cardiac surgery rarely affordable. In this article, we report on a humanitarian project by the NGO EMERGENCY, build run Salam Centre for Cardiac Surgery Sudan. This hospital center of excellence offering free-of-charge, high-quality treatment patients needing open-heart advanced rheumatic congenital disease. Since it opened 2007, more than 8,000 have undergone...
Terrorist attacks with large numbers of civilian victims are not uncommon in war-torn countries, and present a unique challenge for health care facilities limited resources. However, these events largely underreported little is known about how the mass casualty (MCEs) handled outside military setting.This study retrospective analysis MCE which ensued Kabul Airport suicide attack (August 26, 2021) at EMERGENCY NGO Hospital (Afghanistan).Within 6 hours, 93 causalities presented our hospital....
Abstract The annual incidence of blocked mechanical valvular prosthesis (BMVP) is 0.3–5.7%. 78% cases are due to thrombosis and development pannus the second more frequent etiology. risk higher for mitral prosthesis, during 1st year after valve replacement, poor INR trend. TEE gold standard diagnoses, but it seldom required if adequate TTE cine–fluoroscopy performed. As therapy, redo surgery recommended in case NYHA III–IV patients or presence big thrombi: contraindicated too high–risk,...
Abstract Status asthmaticus is an acute exacerbation of asthma that unresponsive to initial treatment with bronchodilators and can rapidly escalate into ventilatory failure. The clinical picture severe include agitation, drowsiness or confusion, breathlessness at rest, tachypnea, use accessory respiratory muscles, tachycardia, pulsus paradoxus. Pharmacological treatments but are not limited beta–2–mimetics, anticholinergic agents, magnesium sulphate, steroids aminophylline. Asthma...
It is traditionally believed that edema associated with brain contusion vasogenic. The objective of this study was to quantify and characterize the in cortical coupled early hypoxia hypotension. Sprague-Dawley rats were randomised into six groups: Sham, Trauma moderate (Tm), severe (Ts), Hypoxia Hypotension (HH), Tm Ts HH (THHm; THHs). induced controlled impact; secondary insults lasted 30 minutes. Water content measured using tissue longitudinal relaxation time (T1). Apparent diffusion...
Jugular saturation (SjvO2) monitoring was performed in 26 SAH patients to evaluate the incidence of normal (0.56-0.74) and pathological SjvO2 values this population describe its time course first 12 days. We also attempt quantify influence systemic cerebral hemodynamics on assess relationship between injury volume measured CT scan SjvO2. Mean 0.66 +/- 0.07 (354 samples, median 0.67, range 0.43-0.89). 73% observations (259/354) were range. On serial measurements, we identified only 37/354...