A5046626061- Microbial metabolism and enzyme function
- Cancer, Hypoxia, and Metabolism
- Aldose Reductase and Taurine
- Heterotopic Ossification and Related Conditions
- Social Sciences and Governance
- Social Policies and Family
- Inflammatory mediators and NSAID effects
- Microtubule and mitosis dynamics
- Alcohol Consumption and Health Effects
- T-cell and Retrovirus Studies
- Cancer-related Molecular Pathways
- Kruppel-like factors research
- Education, sociology, and vocational training
- Healthcare Systems and Practices
- Chronic Myeloid Leukemia Treatments
- Bone health and treatments
- Hippo pathway signaling and YAP/TAZ
- Sociology and Education Studies
- Signaling Pathways in Disease
- Cancer Research and Treatments
- Fibroblast Growth Factor Research
- Ubiquitin and proteasome pathways
- Macrophage Migration Inhibitory Factor
- Radiopharmaceutical Chemistry and Applications
- Invertebrate Immune Response Mechanisms
Université Claude Bernard Lyon 1
2000-2024
Inserm
2011-2024
HES-SO Fribourg
2020
Pathophysiology, Diagnosis and Treatment of Bone Diseases
2019
Bipar
2013
Centre National de la Recherche Scientifique
1999-2011
Centre Antoine Lacassagne
2011
Institut de Biologie et de Chimie des Protéines
1999-2011
Centre National pour la Recherche Scientifique et Technique (CNRST)
2006
Laboratoire de Biologie et Modélisation de la Cellule
1999-2005
Adaptation to hypoxia is a driving force for tumor progression that leads therapy resistance and poor clinical outcome. Hypoxic responses are mainly mediated by hypoxia-inducible transcription factor-1 (HIF-1). One critical HIF-1 target mediating lysyl oxidase (LOX), which catalyzes cross-linking of collagens elastin in the extracellular matrix, thereby regulating tissue tensile strength. Paradoxically, LOX has been reported be both upregulated downregulated cancer cells, especially...
Lysyl oxidase (LOX) is a secreted copper-dependent amine whose primary function to drive collagen crosslinking and extracellular matrix stiffness. LOX in colorectal cancer synergizes with hypoxia-inducible factor-1 (HIF-1) promote tumor progression. Here we investigated whether LOX/HIF1 endows cells full competence for aggressive colonization bone. We show that high expression tumors from patients was associated poor clinical outcome, irrespective of HIF-1 In addition, expressed by the bone...
Deux dispositifs de formation en travail social impliquant des personnes concernées sur la base leurs savoirs d’expérience sont analysés. Plusieurs enjeux pédagogiques discutés : le rapport entre expérience vécue et savoir construit, transformation du rôle pédagogique formateurs, diversité profils ainsi que leur recrutement, susceptible produire l’exclusion ou l’institutionnalisation.
The human T-cell lymphotrophic virus, type 1 Tax protein can interact via its C terminus with various proteins including a PDZ domain. In this work, one of them, TIP-1, is characterized as cytoplasmic 14-kDa mainly corresponding to A two-hybrid screen performed TIP-1 bait showed that it interacts the homologue rhotekin was previously identified in mice Rho effector. Both and mouse rhotekins exhibit at their termini sequence QSPV-COOH matches X(S/T)XV-COOH consensus known for recognizing...
ABSTRACT Several viral proteins expressed by DNA or RNA transforming viruses have the particular property of binding via their C-terminal end to various cellular with PDZ domains. This study is focused on protein TIP-2/GIPC, which was originally identified in two-hybrid screens performed two different baits: human T-cell leukemia virus type 1 Tax oncoprotein and regulator G signaling RGS-GAIP. Further studies shown that TIP-2/GIPC also able associate cytoplasmic domains transmembrane...
Abstract Lysyl oxidase initiates the enzymatic stage of collagen and elastin cross-linking. Among five isoforms comprising lysyl family, LOX is better studied. associated to an antitumor activity in ras-transformed fibroblasts, its expression down-regulated many carcinomas. The aim this work was shed light on functions within epidermis by studying human basal squamous cell carcinomas analyzing effect inhibition protein absence keratinocytes behavior a skin equivalent. In both carcinomas,...
p53 and the retinoblastoma (RB) pocket proteins are central to control of progression through G1 phase cell cycle. The RB protein family is downstream controls S-phase entry. Disruption actin assembly arrests nontransformed mammalian fibroblasts in G1. We show that this arrest requires intact function, but surprisingly does not require p53. Thus, with normal function reversibly on exposure inhibitors regardless their status. By contrast, triple knockout mouse embryo T antigen–transformed rat...
ABSTRACT The mouse int-6 gene was identified in mammary tumors as an integration site for the tumor virus. Its human counterpart encodes a product that interacts with Tax viral oncoprotein of T cell leukaemia virus type 1. This interaction impedes localisation over-expressed Int-6 nuclear bodies containing promyelocytic (PML). In this study, is characterised 52 kDa protein localised within primary lymphocytes. Screening B cDNA library proteins interact led to isolation four clones coding...
We previously identified TD-60 (RCC2) as a mitotic centromere-associated protein that is necessary for proper completion of mitosis. now report an essential regulator cell cycle progression during interphase. siRNA suppression blocks mammalian G₁/S phase cells and G₂ into Prolonged arrest occurs both in non-transformed transformed lacking functional p53. associates with Rac1 Arf6 has recently been demonstrated to be element α5β1 integrin cortactin interactomes. These associations known...
Cellular senescence, a stable proliferation arrest, is induced in response to various stresses. Oncogenic stress-induced senescence (OIS) results blocked and constitutes fail-safe program counteracting tumorigenesis. The events that enable tumor benign senescent state escape from OIS become malignant are largely unknown. We show lysyl oxidase activity contributes the decision maintain senescence. Indeed, human epithelial cell constitutive expression of LOX or LOXL2 protein favored escape,...
The primary function of the lysyl oxidase (LOX) family, including LOX and its paralogue LOX-like (LOXL)-2, is to catalyze covalent crosslinking collagen elastin in extracellular matrix. LOXL2 are also facilitating breast cancer invasion metastatic spread visceral organs (lungs, liver)
Based on a study that we carried out in Geneva between 2013 and 2015, this paper suggests the anti-begging law adopted by High Council 2007 can be understood way of managing urban cohabitation with marginalized populations. In response to “poverty management”, argue continued occupation public space people wh o practice begging as them implementing their own “right city” anyway, subversive sense meant Lefebvre.
Cet article se fonde sur une recherche menee en Suisse francophone la maniere dont categorie des « jeunes adultes a l’aide sociale » est configuree les plans politique, institutionnel et au niveau de l’intervention sociale directe. Les resultats presentes restituent comment professionnels caracterisent ce public, l’identifient legitiment leurs interventions son egard. Une typologie proposee differents roles professionnels.
Searchable abstracts of presentations at key conferences on calcified tissues ISSN 2052-1219 (online)
<div>Abstract<p>Lysyl oxidase (LOX) is a secreted copper-dependent amine whose primary function to drive collagen crosslinking and extracellular matrix stiffness. LOX in colorectal cancer synergizes with hypoxia-inducible factor-1 (HIF-1) promote tumor progression. Here we investigated whether LOX/HIF1 endows cells full competence for aggressive colonization bone. We show that high <i>LOX</i> expression tumors from patients was associated poor clinical outcome,...
Supplementary Figure 2 from The HIF-1–Inducible Lysyl Oxidase Activates HIF-1 via the Akt Pathway in a Positive Regulation Loop and Synergizes with Promoting Tumor Cell Growth