A5049570070- Birth, Development, and Health
- Schizophrenia research and treatment
- Genetics, Aging, and Longevity in Model Organisms
- Chronic Disease Management Strategies
- Dementia and Cognitive Impairment Research
- Diet and metabolism studies
- Electroconvulsive Therapy Studies
- Health disparities and outcomes
- Mental Health Treatment and Access
- Treatment of Major Depression
- Stress Responses and Cortisol
- Thyroid Disorders and Treatments
- Health Systems, Economic Evaluations, Quality of Life
- Bipolar Disorder and Treatment
- Diabetes Management and Research
- Maternal Mental Health During Pregnancy and Postpartum
- Cardiac Health and Mental Health
- Pharmaceutical Practices and Patient Outcomes
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Mental Health and Psychiatry
- Genetic Neurodegenerative Diseases
- Adipose Tissue and Metabolism
- Global Health Care Issues
- Healthcare cost, quality, practices
- Diabetes Treatment and Management
University of Copenhagen
2016-2025
Frederiksberg Hospital
2021-2025
Copenhagen University Hospital
2025
Rigshospitalet
2019-2024
Center for Clinical Research and Prevention
2024
GTx (United States)
2022
Mental Health Services
2021
Capital Region of Denmark
2021
Leiden University Medical Center
2008-2015
GGZ inGeest
2013-2015
To compare the risk of mortality nonagenarian siblings with that sporadic nonagenarians (not selected on having a sibling) and to prevalence morbidity in their offspring offsprings' partners.Longitudinal (mortality risk) cross-sectional (disease prevalence).Nationwide sample.The Leiden Longevity Study consists 991 derived from 420 Caucasian families, 1,365 offspring, 621 partners. In 85-plus Study, 599 subjects aged 85 were included, whom 275 attained age 90 (sporadic nonagenarians).All...
A relation between low thyroid activity and prolonged life span in humans has been observed. Several studies have demonstrated hereditary genetic influences on function.The objective of the study was to test whether associated with extreme longevity constitutes a heritable phenotype, which could contribute familial observed Leiden Longevity Study.This cross-sectional study.The conducted at university hospital city Leiden, The Netherlands.Eight hundred fifty-nine nonagenarian siblings (median...
ABSTRACT Background Mental disorders are associated with excess risk of death from unnatural and natural causes, but few studies have differentiated causes among patients major depression. We examined cumulative relative risks all‐cause cause‐specific mortality in individuals depression up to 50 years after diagnosis according sex, age, time since diagnosis. Methods In this nationwide matched‐cohort study, we included diagnosed Danish National Patient registries 1970 through 2021 a 1:5...
Insulin resistance is a risk factor for various age-related diseases. In the Leiden Longevity study, we recruited long-lived siblings and their offspring. Previously, showed that, compared to controls, offspring of had better glucose tolerance. Here, groups from controls relation between insulin in nonfasted serum (n = 1848 subjects) quantitation action using two-step hyperinsulinemic-euglycemic clamp 24 subjects). Groups were similar with regard sex distribution, age, body mass index. We...
Objective To examine the incidence of suicidal and violent behaviour following initiation antidepressant medication. Method Cohorts 997 911 conscripts 95 794 patients with a first‐time affective disorder were followed for purchase medication, suicide, suicide attempts conviction crime in Danish registries between 1997 through 2015. Incidence outcomes was estimated first 28 days, 28–365 days or later after antidepressants study entry. Results Of 16.5% 73.7% disorders initiated 3–4 times...
Importance Large-scale evidence for the efficacy of continuation and maintenance electroconvulsive therapy (c/mECT) is lacking. Objective To provide an exhaustive naturalistic insight into real-world outcomes cost-effectiveness c/mECT in a large dataset. Design, Setting, Participants This cohort study included all patients Danish National Patient Registry who initiated treatment with ECT from 2003 through 2022. The data were analyzed October 2023 to February 2024. Exposures ECT. An algorithm...
OBJECTIVES: To explore measures of metabolic syndrome and glucose metabolism in families with exceptional longevity. DESIGN: Case–control study. SETTING: A university hospital Leiden, the Netherlands. PARTICIPANTS: One hundred twenty‐one offspring nonagenarian siblings, who were enriched for familial factors promoting longevity, 113 their partners. No subject had diabetes mellitus. MEASUREMENTS: Prevalence was determined according to criteria Third Report National Cholesterol Education...
The hypothalamo-pituitary-thyroid axis has been widely implicated in modulating the aging process. Life extension effects associated with low thyroid hormone levels have reported multiple animal models. In human populations, an association was observed between function and longevity at old age, but beneficial of metabolism middle age remain elusive. We compared serum parameters a group middle-aged offspring long-living nonagenarian siblings control their partners, all participants Leiden...
Aging | doi:10.18632/aging.100071. Maarten P. Rozing, Rudi G.J. Westendorp, Marijke Frölich, Anton J.M. de Craen, Marian Beekman, Bastiaan T. Heijmans, Simon Mooijaart, Gerard-Jan Blauw, Eline Slagboom, Diana van Heemst, on behalf of the Leiden Longevity Study (LLS) Group
Reduced insulin/insulin-like growth factor 1 (IGF-1) signaling has been associated with longevity in various model organisms. However, the role of insulin/IGF-1 human survival remains controversial. The aim this study was to test whether circulating IGF-1 axis parameters associate old age and functional status nonagenarians from Leiden Longevity Study. This examined 858 Dutch nonagenarian (males≥89 years; females≥91 years) siblings 409 families, without selection on health or demographic...
Background: The effects of electroconvulsive therapy are usually estimated from changes in depression scales studies with relatively small patient samples. Larger samples can be achieved epidemiological registers, which provide information on other social and clinical predictors, results risks. Aims: To examine whether severity predicts the use therapy, risk re-hospitalization, suicidal behaviour mortality following patients major depression. Methods: A cohort 92,895 diagnosed single or...
Current metrics for estimating a scientist's academic performance treat the author's publications as if these were solely attributable to author. However, this approach ignores substantive contributions of co-authors, leading misjudgments about individual's own scientific merits and consequently misallocation funding resources positions. This problem is becoming more urgent in biomedical field where number collaborations growing rapidly, making it increasingly harder support best scientists....
Increasing evidence suggests that pro-inflammatory cytokines are at play in lowering peripheral thyroid hormone levels during critical illness. Conversely, hormones have been suggested to enhance production of inflammatory cytokines. In view these considerations, we hypothesized a mutual association between triiodothyronine and Therefore evaluated the relation both circulating induced markers serum function parameters Leiden 85-plus Study. We found higher were associated with lower free...