OBJECTIVES: To examine the relationship between obesity and depressive symptoms taking into account different measures for (body mass index (BMI), waist circumference (WC), waist-to-hip ratio (WHR)) symptom clusters. DESIGN: Cross-sectional population-based survey. SETTING: Baseline data of Nijmegen Biomedical Study. PARTICIPANTS: One thousand two hundred eighty-four persons aged 50 to 70. MEASUREMENTS: Obesity (BMI, WC, WHR) were measured, latter using Beck Depression Inventory (BDI)....

Oral tetrahydrocannabinol (THC) is currently studied for its possible efficacy on dementia-related neuropsychiatric symptoms (NPS), but might lead to increased risk of falling. This was a randomised, double-blind, crossover study evaluate the effects THC mobility in dementia patients. Eighteen community-dwelling patients ( M age =77 years) received 1.5 mg oral twice daily and placebo, random order, three days, separated by four-day washout. Balance gait were assessed using SwayStar TM...

Background Depression is associated with the metabolic syndrome (MS). We examined whether dysregulation predicted 2-year course of clinical depression. Method A total 285 older persons (⩾60 years) suffering from depressive disorder according to DSM-IV-TR criteria was followed up for 2 years. Severity depression assessed Inventory Depressive Symptomatology (IDS) at 6-month intervals. Metabolic defined National Cholesterol Education Programme (NCEP-ATP III). applied logistic regression and...

Abstract Background To examine the mortality risk of current and life-time depressive as well anxiety disorders, whether this is moderated by sex or age, can be explained lifestyle and/or somatic health status. Methods A cohort study (Lifelines) including 141,377 participants (18–93 years) which were followed-up regarding for 8.6 years (range 3.0–13.7). Baseline disorders according to Diagnostic Statistical Manual Mental Disorders, fourth edition criteria assessed with Mini International...

BackgroundSocietal measures in context of the COVID-19 outbreak forced us to transform our schema therapy based day-treatment for older adults with chronic affective disorders and personality problems into an online program. The objective this paper is present first impressions transformation.MethodsUsing over-the-phone instructions initially, all patients were able participate To reduce screen-time patients, nonverbal therapies shortened. Four aged 64–70 years, started...

Objective The aim of the study was to describe successful treatment delirium with electroconvulsive therapy (ECT). Methods method a case report. Results A 75-year-old man, recently diagnosed carcinoma parotid gland, admitted fluctuating psychiatric syndrome. Delirium diagnosed, although an acute underlying somatic cause could not be readily established. Antipsychotics and benzodiazepines were effective. After 7 sessions ECT, all symptoms ceased. This enabled him receive radiotherapy for his...

Objective Depression has been associated with increased mortality rates, and modifying mechanisms have not yet elucidated. We examined whether specific subtypes or characteristics of late-life depression predict mortality.Methods A cohort study including 378 depressed older patients according to DSM-IV criteria 132 never comparisons. The predictive value on the six-year rate, as well their interaction somatic disease burden antidepressant drug use, were studied by Cox proportional hazard...

Abstract Background The frailty index (FI) is a well-recognized measurement for risk stratification in older people. Among middle-aged and people, we examined the prospective association between FI mortality as well its course over time relation to multimorbidity specific disease clusters. Methods A was constructed based on either 64 (baseline only) or 35 health deficits follow-up) among people aged ≥ 40 years who participated LifeLines, population-based cohort living Northern Netherlands....

Abstract Introduction Depressive disorder has been conceptualised as a condition of accelerated biological ageing. We operationalised frailty index (FI) marker for ageing aimed to explore the bidirectional, longitudinal association between and either depressive symptoms or disorder. Methods A cohort study with 6‐year follow‐up including 377 older (≥60 years) outpatients DSM‐IV‐defined 132 never‐depressed controls. Site visits at baseline, 2 were conducted included CIDI 2.0 assess relevant...

This paper explores recently emerging challenges in Medical Assistance Dying on Psychiatric Grounds (MAID-PG), focusing ethical, clinical, and societal perspectives. Two themes are explored. First, the growing number of young MAID-PG requestors public platform given to requests. Ethically, media portrayal, particularly patients' testimonials, requires scrutiny for oversimplification, acknowledging potential a Werther effect alongside absence Papageno effect. highlights need better...

Organ donation after medical assistance in dying (MAID) on psychiatric grounds is a relatively new practice that poses complex ethical challenges. This paper explores several issues are important for guiding current and future practice. While organ MAID may alleviate shortages, it also prompts concerns regarding the instrumentalization of human life. However, can be argued if patient wishes to donate, based insight deliberation, person not just regarded as means. implies decision-making...

Aging-related physiological changes like metabolic dysregulation and physical frailty are associated with depression worsen its prognosis. Since central obesity is a key component of the syndrome sarcopenia frailty, we examined association sarcopenic cross-sectional over time.Cohort study depressed patients nondepressed comparison group.Primary secondary mental health care.Three hundred seventy-eight older (≥60 y) which 285 were followed up at 2 years 132 persons participating in Netherlands...

Child abuse is a major global burden with an enduring negative impact on mental and physical health. A history of child consistently associated worse cognitive performance among adults; data in older age groups are inconclusive. Since affective symptoms functioning interrelated persons, synergistic effect can be assumed patients who also have suffered from abuse. This study examines the association between such patients.Cross-sectional were collected 'Routine Outcome Monitoring for Geriatric...

Frailty is an important concept for risk stratification in clinical practice, but it hardly acknowledged at all mental healthcare settings. This paper aims to assess the impact of frailty on course depression and anxiety, these affective disorders frailty.

Abstract Background The deficit accumulation method considers the ageing process underlying frailty as a random of health deficits. Objective Although Adverse Childhood Experiences (ACE) have consistently been associated with onset mental disorders and somatic diseases during adolescence midlife, it remains unknown whether ACE still exert detrimental effects in late life. Therefore, we examined cross-sectionally prospectively association between among community-dwelling older people. Design...

Background Depression increases the risk of subsequent vascular events in both cardiac and non-cardiac patients. Atherosclerosis, underlying process leading to events, has been associated with depression. This association, however, may be confounded by somatic-affective symptoms being a consequence cardiovascular disease. While taking into account differentiation between cognitive-affective depression, we examined association depression atherosclerosis community-based sample. Method In 1261...

A low plasma 25-OH vitamin D3 level is a universal risk factor for wide range of diseases and has also been implicated in late-life depression. It currently unknown whether the biologically active form D, that is, 1,25-(OH)2 D3, decreased depression, or D levels correlate with specific depression characteristics. We determined parathormone 355 depressed older persons 124 non-depressed comparison subjects (age⩾60 years). Psychopathology was established Composite International Diagnostic...