Andrographis paniculata is widely used as a traditional medicine in Asian countries. It has been classified safe and non-toxic by Chinese medicine. The investigation of the biological activities A. still focused on crude extract isolation its main active compound, andrographolide, derivatives. However, use andrographolide alone shown to exacerbate unwanted effects. This highlights importance developing fraction with enhanced efficacy an herbal-based In this study, extraction fractionation...

Ultraviolet (UV) irradiation is a serious problem for skin health thus the interest in research to develop sunscreen agent has been increasing. Chalcone promising compound be developed as its chromophore absorbs UV region. Therefore, present work, we synthesized eight chalcone derivatives through Claisen–Schmidt condensation at room temperature. The evaluation of optical properties each region was conducted spectroscopic and computational studies. chalcones were obtained good yields they...

Combinatorial synthesis of a 1,5-polyol system corresponding to the C1−C14 unit amphidinol 3 (AM3) and its diastereomers was achieved via chemoselective cross metathesis as key step. Comparison 13C NMR data synthetic specimens with that AM3 led controversy regarding originally proposed structure. From GC-MS analysis degradation product, absolute configuration at C2 has been revised be R.

Vernonia amygdalina has been reported as a potential antidiabetic agent. One of the mechanisms in diabetes mellitus treatment is inhibition α-amylase enzyme's action. This study aimed to identify presence secondary metabolites leaf extract, which inhibitors through phytochemical screening combined with metabolomic analysis. Methanol extract from was partitioned into n-hexane, dichloromethane (DCM), and ethyl acetate. From this process, methanol, hexane, DCM, acetate extracts were obtained....

Snake envenomation is a severe economic and health concern affecting countries worldwide. venom carries wide variety of small peptides proteins with various immunological pharmacological properties. A few key research areas related to snake venom, including its applications in treating cancer eradicating antibiotic-resistant bacteria, have been gaining significant attention recent years. The goal the current study was analyze global profile literature research. This presents bibliometric...

To investigate the antioxidant, antibacterial, antimalarial activities and cytotoxicity of n-hexane, ethyl acetate, n-butanol, aqueous fractions from a crude extract Lobophytum sp. This organism was collected Selayar Islands (South Sulawesi). The antioxidant activity performed by 1,1-diphenyl-2-picryl hydrazyl radical scavenging method. All were examined for their using brine shrimp lethality bioassay heme polymerization inhibitory assay activity. It found that n-butanol exhibited with IC50...

Curcuma longa or turmeric is known to have many functions in the field of foodstuff, cosmetics, and traditional medicines.The rhizome contains curcuminoid, especially curcumin which believed be active compound responsible for pharmacological activities.The authenticity C. very important avoid adulteration practices.The objective this study was develop thin layer chromatography (TLC) analysis combined with H-NMR metabolite fingerprinting multivariate authentication powder.Determination pure...

(PDF) Graphical Abstract: In this study, the chloro-substituted hydroxyxanthones were prepared by cyclodehydration of acid derivatives and substituted phenol in presence Eaton reagent, followed halogenations step to electrophilic substitution chlorine a moderate yield. The vitro anticancer activity study on various cell lines revealed that chloro functional group increases hydroxyxanthone derivatives. molecular docking showed there was binding interaction between chloro-hydroxyxanthone amino...

The study aims to develop an effective, efficient, and reliable method using Fourier Transform Infrared (FTIR) spectroscopy with Attenuated Total Reflection (ATR) combined chemometric for identifying the synthetic drug in Indonesian herbal medicine known as Jamu. Jamu powders, Metamizole, binary mixture of Metamizole were measured FTIR-ATR at mid-infrared region (4000-650 cm-1). obtained spectra profiles further analyzed by Principal Component Analysis, Partial Least Square Regression,...

A study of TiO2(rod)-SiO2 composites coated with polyaniline (PANI) has been performed. PANI was synthesized through in-situ polymerization aniline at various concentration (0.0137, 0.0274, and 0.0411 M) on the composite under acidic condition. confirmed by appearance C=N, C=C vibrations redshift band-gap from 3.14 eV for into 3.0 TSP01 composite. It is also shown that does not change crystal structure as XRD pattern. The TEM image shows a mixed SiO2 TiO2(rod)-PANI layers oxides layers....

Antimicrobial peptide (AMP) peptide-based lead compound has become interesting target in developing new antibiotics. AMP is possibly generated through the digestion of protein. The protein castor (Ricinus communis) seed characterized as a ribosome-inactivating (RIP) that can be source AMP. objectives this research are to identify antibacterial peptides from Ricinus communis hydrolysate. was isolated using sodium dodecyl sulfate and subsequently digested trypsin. hydrolysate fractionated...

Through experimental along with molecular docking techniques of potential fraction, this study intended to evaluate the essential phytochemical elements Tristaniopsis merguensis leaflets as well antioxidant, photoprotective, cytotoxic activities. The DPPH and ABTS tests were used antioxidant efficacy n-hexane (HPF), ethyl acetate (EPF), methanol (MPF) fractions. Using an in-vitro solar protection factor (SPF) assessment, photoprotective ability T. components against UV damage was examined....

Bacterial infections pose significant threats to human health, particularly due the rise of antibiotic-resistant strains. Identifying new sources effective antibiotics is therefore crucial for combating these resistant pathogens. This study aims isolate novel Streptomyces species and profile their secondary metabolites through extraction high-resolution mass spectrometry (HRMS) analysis. Furthermore, antibacterial activity extract containing was assessed in vitro agar well diffusion method...

Among other homologues, amphidinol 3 (AM3) is the most potent antifungal compound isolated from dinoflagellate Amphidinium klebsii.AM3 undergoes conformational changes in organic solvents while it takes relatively fixed configuration a membrane model.By using NMR data of peracetyl AM3, we were able to confirm C50-C51 AM3 which remained uncertain our previous study.

Some new hydroxyxanthone compounds were prepared through one pot cyclodehydration reaction of hydroxybenzoic acid derivatives (salicylic or resorcylic acid) with phloroglucinol pyrogallol in the presence Eaton's reagent (P 2 O 5 /MeSO 3 H).The synthesized screened for their antioxidant activities by 2,2-diphenyl-1-picrylhydrazyl (DPPH) methods to determine inhibitory concentration (IC 50 ).Cytotoxicity was also evaluated MMT assay on Vero cell line.It observed that position and number...

Analysis of acetaminophen, mefenamic acid, sibutramine hydrochloride, and sildenafil citrateEva Susanty Simaremare, Rizka Agustine Susilowati, Yeyen Dwi Astuti, Rusadi Hermawan, Elsye Gunawan, Rani Dewi Pratiwi, Rusnaeni

Anticancer peptide is one of the target in development new anticancer drug. Bioactive can be originated from isolated free or produced by hydrolysis protein. Protein main component Naja kaouthia venom, and due to toxicity it assessed as source peptides. This study aims characterize venom protein identify peptides snake N. anticancer. Proteome analysis was employed trypsin completed with HRMS database query. Preparative tryptic followed reverse-phased fractionation anti breast cancer activity...

Macroalgae is a protein source with the potential to yield antimicrobial peptides (AMPs) that exhibit wide range of biological activities. This study aimed find bioactive peptide-based antibacterial compounds from marine macroalgae Chondrus crispus hydrolysate. The were isolated by solid phase extraction strong cation exchanger trypsin-digested and α -chymotrypsin-digested hydrolysates. Certain fractions hydrolyzed displayed good inhibition zone, α-chymotrypsin-digested fraction eluted at pH...

Objective: The objective of this study was to apply 1H-NMR spectroscopy-based metabolite fingerprinting in combination with multivariate analysis for authentication turmeric (Curcuma longa) from C. heyneana and manga.Methods: Partial least square-discriminant (PLS-DA) orthogonal projections latent structures-discriminant (OPLS-DA) were used differentiation authentic adulterated longa manga heyneana. variables peaks certain chemical shifts at optimized spectra longa.Results: All the samples...

Indonesian bay leaves [IBL; Syzygium polyanthum (Wight) Walp.] are frequently used as a seasoning in various cuisines. The potential of IBL extract an antioxidant and aroma source based on the leaf maturities withering durations is not yet known. Therefore, present work aimed to study effect changes potentials compound. Results showed that total phenolic, flavonoid, tannin contents old yielded highest values (89.08 gallic acid equivalent (GAE)/g sample, 37.11 mg quercetin (QE)/g 2.72 tannic...

To investigate the total phenolic content, anti-oxidant capacity and cytotoxic activity present in n-hexane, ethyl acetate, n-butanol aqueous fractions of an extract collected at Selayar Island, Indonesia. The antioxidant was performed by 1,1-diphenyl-2-picrylhydrazyl radical scavenging method β-carotene bleaching assay. All from crude Acanthella cavernosa (A. cavernosa) were examined for their cytotoxicity using brine shrimp lethality bioassay heme polymerization inhibitory assay...

Background: Interaction between -NH 2 group of chitosan to -CHO groups glutaraldehyde is critical in lipase immobilization using as a matrix and linker.Since the Deacetylation Degree (DD%) represent number group, it important understand effect DD% value on effectiveness immobilization.Chitosan beads powder have different accessible therefore, influence form also interesting be investigated.Materials Methods: Three chitosans with DD prepared various repetition deacetylation.This was set then...