A5039187049- Synthesis and biological activity
- Bioactive Compounds and Antitumor Agents
- RNA modifications and cancer
- Cancer-related gene regulation
- Epigenetics and DNA Methylation
- Endoplasmic Reticulum Stress and Disease
- Cancer therapeutics and mechanisms
- Heme Oxygenase-1 and Carbon Monoxide
- Genomics, phytochemicals, and oxidative stress
- Autophagy in Disease and Therapy
- Synthesis and Biological Evaluation
- Mercury impact and mitigation studies
- Quinazolinone synthesis and applications
- Advanced Glycation End Products research
- Nuclear Receptors and Signaling
- Macrophage Migration Inhibitory Factor
- Alcohol Consumption and Health Effects
Okayama University
2016-2023
Abstract DNA methyltransferases (DNMTs) catalyze methylation at the C5 position of cytosine with S -adenosyl- l -methionine. Methylation regulates gene expression, serving a variety physiological and pathophysiological roles. The chemical mechanisms regulating DNMT enzymatic activity, however, are not fully elucidated. Here, we show that protein S-nitrosylation cysteine residue in DNMT3B attenuates activity consequent aberrant upregulation expression. These genes include Cyclin D2 ( Ccnd2 ),...
Methylmercury (MeHg) results in cell death through endoplasmic reticulum (ER) stress. Previously, we reported that MeHg induces S-mercuration at cysteine 383 or 386 protein disulfide isomerase (PDI), and this modification the loss of enzymatic activity. Because PDI is a key enzyme for maturation nascent harboring bond, disruption function by ER stress via accumulation misfolded proteins. However, effects on unfolded response (UPR) sensors their signaling remain unclear. In present study,...
Nitric oxide (NO) is a key signaling molecule that has various effects via S-nitrosylation, reversible post-translational modification affects the enzymatic activity, localization, and metabolism of target proteins. As chronic nitrosative stress correlates with neurodegeneration, targets have received focused attention. Macrophage migration inhibitory factor (MIF) plays pivotal role in induction gene expression to control inflammatory responses. MIF acts as ligand for CD74 receptor activates...
Upregulation of nitric oxide (NO) production contributes to the pathogenesis numerous diseases via S-nitrosylation, a post-translational modification proteins. This process occurs due oxidative reaction between NO and cysteine thiol group; however, extent this remains unknown. S-Nitrosylation PRMT1, major asymmetric arginine methyltransferase histones RNA metabolic proteins, was induced by donor treatment. We found that nitrosative stress leads S-nitrosylation 119, located near active site,...
The epidermal growth factor receptor (EGFR) is the most intensively investigated tyrosine kinase. Several EGFR mutations and modifications have been shown to lead abnormal self-activation, which plays a critical role in carcinogenesis. Environmental air pollutants, are associated with cancer respiratory diseases, can also activate EGFR. Specifically, environmental electrophile 1,2-naphthoquinone (1,2-NQ), component of diesel exhaust particles particulate matter more generally, has previously...
[Background] The redox-mediated chemical modification occurs via oxidative reaction between electrophile and cysteine thiol in the presence of an electron acceptor. It is widely recognized that long exposure to or high concentration 1,2-naphthoquinone (1,2-NQ), cigarette ingredients/smoke metabolite naphthalene, results cytotoxic effect. Whereas, low 1,2-NQ specifically stimulates Akt signaling involving cell proliferation anti-apoptosis possibly protein oxidation. In this study, we...
[Background]
Epigenetic dysregulation, such as aberrant DNA methylation, is one of the hallmarks cancer cells, however mechanisms by which these dysregulations occur remain unclear. Previously, we found that methyltransferase 3B (DNMT3B), catalyzes cytosine selectively oxidized several stresses. A cysteine residue modification site on DNMT3B. As oxidation DNMT3B attenuates its enzymatic activity, this reaction may be related to epigenetic regulation. In study, focused cell cycle regulator CCND2 and...
[Background] The epidermal growth factor receptor (EGFR) is the most intensively investigated tyrosine kinase whose mutation or modification leads to abnormal self-activation, which plays a critical role in carcinogenesis. Although environmental air pollutants, are associated with cancer and respiratory diseases, can activate EGFR, detailed mechanisms remain unknown. In this study, we addressed clarify by pollutant 1,2-naphthoquinone (1,2-NQ) disrupts EGFR-Akt signaling promotes oncogenic effects.