A5074575184- Nanoparticle-Based Drug Delivery
- Barrier Structure and Function Studies
- Advanced Drug Delivery Systems
- 3D Printing in Biomedical Research
- Cell Adhesion Molecules Research
- Neuroscience and Neuropharmacology Research
- RNA Interference and Gene Delivery
- Cancer-related molecular mechanisms research
- MicroRNA in disease regulation
- Platelet Disorders and Treatments
- Microbial Metabolism and Applications
- Nanomaterials for catalytic reactions
- Tissue Engineering and Regenerative Medicine
- Circular RNAs in diseases
- Biochemical and biochemical processes
- Tannin, Tannase and Anticancer Activities
- Connective tissue disorders research
- Pluripotent Stem Cells Research
- Electrospun Nanofibers in Biomedical Applications
Fraunhofer Institute for Biomedical Engineering
2020-2024
Jena University Hospital
2013
Friedrich Schiller University Jena
2013
MicroRNAs are regulators of gene expression. A wide-spread, yet not validated, assumption is that the targetome miRNAs non-randomly distributed across transcriptome and targets share functional pathways. We developed a computational experimental strategy termed high-throughput miRNA interaction reporter assay (HiTmIR) to facilitate validation target First, pathways predicted prioritized by means increase specificity positive predictive value. Second, novel webtool miRTaH facilitates guided...
Abstract Human pluripotent stem cell‐derived cardiomyocytes (hPSC‐CMs) represent a valuable tool for in vitro modeling of the cardiac niche and possess great potential tissue engineering applications. However, conventional polystyrene‐based cell culture substrates have adverse effects on due to stress applied by stiff substrate contractile cells. Ultra‐high viscosity alginates offer unique versatility as tunable cultures their biocompatibility, flexible biofunctionalization, stability. In...
The human blood-brain barrier (BBB) represents the interface of microvasculature and central nervous system, regulating transport nutrients protecting brain from external threats. To gain a deeper understanding (patho)physiological processes affecting BBB, sophisticated models mimicking in vivo situation are required. Currently, most vitro cultivated on stiff, semipermeable, non-biodegradable Transwell® membrane inserts, not adequately complexity extracellular environment native BBB....
The treatment of Parkinson’s disease has been moving into the focus pharmaceutical development. Yet, necessity for reliable model systems in development phase made research challenging and vivo models necessary. We have established reliable, reproducible vitro to evaluate binding transport dopamine-loaded PLGA nanoparticles put results context with comparable results. provided similar concerning usability investigated as previously used thus provide a good alternative line 3R principles research.
In vitro model systems of the blood-brain barrier (BBB) play an essential role in pharmacological research, specifically during development and preclinical evaluation new drug candidates. Within past decade, trend research further has moved away from models based on primary cells animal origin towards differentiated derived human induced pluripotent stem (hiPSs). However, this logical progression renewable cell sources opens up questions about transferability results generated models. study,...
Prodigiosenes are a family of red pigments with versatile biological activity. Their tripyrrolic core structure has been modified many times in order to manipulate the spectrum We have looking systematically at prodigiosenes substituted C ring alkyl chains different lengths, assess relevance this substituent context that not investigated before for these derivatives: Cu(II) complexation, DNA binding, self-activated cleavage, photoinduced cytotoxicity and antimicrobial Our results indicate...