A5051208819- Reproductive Biology and Fertility
- Sperm and Testicular Function
- Ovarian function and disorders
- Obesity, Physical Activity, Diet
- Food Security and Health in Diverse Populations
- Knee injuries and reconstruction techniques
- Animal Genetics and Reproduction
- Global Cancer Incidence and Screening
- Obesity and Health Practices
- Pluripotent Stem Cells Research
- Colorectal Cancer Screening and Detection
- School Health and Nursing Education
- Osteoarthritis Treatment and Mechanisms
- Reproductive Physiology in Livestock
- Cancer survivorship and care
- Estrogen and related hormone effects
- Periodontal Regeneration and Treatments
- Health Policy Implementation Science
- Palliative Care and End-of-Life Issues
- Diabetes Management and Education
- Community Health and Development
- Maternal Mental Health During Pregnancy and Postpartum
- Cardiovascular Health and Risk Factors
- Mesenchymal stem cell research
- Tendon Structure and Treatment
People Designs (United States)
2024
University of Milan
2009-2021
Istituto Ortopedico Galeazzi
2016-2019
Istituti di Ricovero e Cura a Carattere Scientifico
2017-2019
Université Laval
2015
West Virginia University
1998-2012
Durham Technical Community College
2012
UConn Health
2012
UNC Lineberger Comprehensive Cancer Center
1997-2011
Istituto Sperimentale Italiano Lazzaro Spallanzani
2006-2009
The WATCH (Wellness for African Americans Through Churches) Project was a randomized trial comparing the effectiveness of 2 strategies to promote colorectal cancer preventive behaviors among 587 American members 12 rural North Carolina churches. Using X factorial research design, authors compared tailored print and video (TPV) intervention, consisting 4 individually newsletters targeted videotapes, with lay health advisor (LHA) intervention. Results showed that TPV intervention significantly...
Oocyte in vitro maturation (IVM) has become a valuable technological tool for animal breeding and cloning the treatment of human infertility because it does not require administration exogenous gonadotropin to obtain fertilizable oocytes. However, embryo development after IVM is lower compared vivo maturation, most likely oocytes collected are heterogeneous with respect their developmental competencies. Attempts improve outcome have relied upon either prematuration culture (PMC) or two-step...
Although the oocyte is largest cell in body and an unavoidable phase life, its physiology still poorly understood, other types provide little insight into unique nature. Even basic cellular functions such as energy metabolism are not yet fully understood. It known that mitochondria of female gamete exhibit immature form characterized by limited production from glucose oxidative phosphorylation. We show bovine uses alternative means to maintain ATP during maturation, namely, adenosine salvage...
In the pig, efficiency of in vitro embryo production and somatic cell nuclear transfer (SCNT) procedures remains limited. It has been suggested that prematuration treatments (pre-IVM) based on prolongation a patent, bidirectional crosstalk between oocyte cumulus cells through gap junction mediate communication (GJC), with maintenance proper level cAMP, could improve developmental capability oocytes. The aim this study was to assess: 1) dose-dependent effects cilostamide maturation kinetics,...
Purpose. The purpose of this study was to gain a better understanding the cultural meanings that shape breast cancer screening behavior older African-American women. Design. Qualitative research methods elicited social and themes related screening. Setting. Focus group interviews were conducted in natural settings (churches, etc.) Subjects. Interviews with 132 members from 14 networks Measures. A focus guide asked about 1) perceived risk cancer, 2) behavioral intentions screening, 3) health...
SUMMARY Major remodelling of the chromatin enclosed within germinal vesicle occurs towards end oocyte growth in mammals, but mechanisms involved this process are not completely understood. In bovine, four distinct stages compaction—ranging from a diffused state (GV0) to fully compacted configuration (GV3)—are linked gradual acquisition developmental potential. To better understand molecular events and identify mRNA modulations occurring during GV0‐to‐GV3 transition, transcriptomic analysis...
Progesterone Receptor Membrane Component 1 (PGRMC1) is expressed in both oocyte and ovarian somatic cells, where it found multiple cellular sub-compartments including the mitotic spindle apparatus. PGRMC1 localization maturing bovine oocytes mirrors its suggesting a possible common action mitosis meiosis. To test hypothesis that altering activity leads to similar defects meiosis, function was perturbed cultured granulosa cells (bGC) effect on meiotic progression assessed. RNA...
Does the gene expression profile of cumulus cells (CC) accompanying oocytes with different degrees chromatin compaction within germinal vesicle (GV) reflect oocyte's quality and response in culture during in-vitro embryo production (IVP). The transcriptomic CC is related to oocyte competence, setting stage for development customized pre-maturation strategies improve IVP. Oocytes complete acquisition their competence antral follicle development. During this period, configuration GV changes...
Beginning in 1990, Georgia's Special Supplemental Nutrition Program for Women, Infants, and Children (WIC) initiated 5 new strategies to promote breastfeeding among its pregnant postpartum clients. These were implemented 1991, each be provided as an addition standard program of counseling on distributing appropriate literature: 1) enhanced education, 2) breast pump loans, 3) hospital-based programs, 4) peer counseling, 5) community coalitions. The education strategy provides access a hotline...
The effect of cigarette smoking on the risk early-stage endometrial cancer was evaluated in a population-based case-control study women aged 40 to 69 years from upstate New York. Two hundred with diagnosed between 1979 and 1981, 200 matched community controls were interviewed person asked about habits other factors. Statistical analysis revealed significant decline relative increased (P < 0.05). This strongly modified well-known increase body weight. Among smokers did not weight, whereas...
DNA methyltransferase-1 (Dnmt1) is involved in the maintenance of methylation patterns and crucial for normal mammalian development. The aim present study was to assess localization Dnmt1 cow, during latest phases oocyte differentiation early stages segmentation. expression were assessed oocytes according chromatin configuration, which turn provides an important epigenetic mechanism control global gene represents a morphological marker differentiation.We found that initial condensation...
Several reports suggest the participation of progesterone receptor membrane component 1 (PGRMC1) in signaling reproductive system. This study aimed at investigating presence and localization PGRMC1 bovine ovary, oviduct uterus, during follicular luteal phases estrous cycle. In has been detected surface germinal epithelium, granulosa cells, theca cells vesicle oocytesat all stages folliculogenesis. corpus luteum expression was influenced by stage oviducts uterus horns, immunolocalized luminal...
Epigenetic modifications are established during gametogenesis and preimplantation embryonic development. Any disturbance of the normal natural environment these critical phases could cause alterations epigenetic signature. Histone acetylation is an important modification involved in regulation chromatin organization gene expression. The present study was aimed to determine whether proper establishment post-translational histone H4 at lysine 8 (AcH4K8), 12 (AcH4K12) 16 (AcH4K16) equine...
In a previous survey concerning cows of reproductive age, we demonstrated that oocytes isolated from ovaries with <10 medium antral follicles 2 to 6 mm in diameter (low ovaries; Lo) show less developmental competence than collected >10 (high Hi). The aim the present study was evaluate whether defective endothelial nitric oxide synthase/nitric (eNOS/NO) system and vasculature healthy is likely reduce oocyte Lo ovaries. Thus, experiments were conducted 1) immunolocalize eNOS protein during...