A5063428562- Health Systems, Economic Evaluations, Quality of Life
- Pharmaceutical Economics and Policy
- Global Health Care Issues
- Diabetes Management and Research
- Pharmaceutical Practices and Patient Outcomes
- Healthcare Systems and Reforms
- Biosimilars and Bioanalytical Methods
- Diabetes Treatment and Management
- Pharmaceutical industry and healthcare
- Blood Pressure and Hypertension Studies
- Economic and Financial Impacts of Cancer
- Medication Adherence and Compliance
- Pharmaceutical studies and practices
- Chronic Disease Management Strategies
- Pharmacology and Obesity Treatment
- Cardiovascular Health and Risk Factors
- Pharmacovigilance and Adverse Drug Reactions
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Global Public Health Policies and Epidemiology
- Pituitary Gland Disorders and Treatments
- COVID-19 Clinical Research Studies
- Cervical Cancer and HPV Research
- Healthcare Systems and Practices
- Health, Environment, Cognitive Aging
- Healthcare Systems and Public Health
Medical University of Sofia
2016-2025
To evaluate the expected life expectancy in patients with diabetes Bulgaria and to compare it of non-diabetic population country.It is a retrospective observational study on individuals diagnosed diabetes, compared for period 2012-2015. Data from national register statistical institute were used construct life-tables probability survival t-test Chi Square test. Confounder analysis was done by age, sex, type diabetes. All-cause mortality deaths diabetic analyzed. Kaplan-Meier curves...
Background: Type 2 diabetes is a chronic disease with high global prevalence and significant social economic burden. The pandemic affected patients’ diagnostics medicines dispensing. Diabetes was among the most-affected conditions during lockdown due to limited resources unaffordable medicines. impact of on utilisation cost has not been thoroughly studied, which inspired us conduct current study. Objectives: study explored dynamics, changes in antidiabetic utilisation, public expenditure...
Background and Objectives: Hypertension is found as the leading cardiovascular disease in Bulgaria most frequent lifelong condition with a high risk of non-adherence. The aim this study to assess hypertension patients’ adherence medication therapy by using self-efficacy for appropriate use scale (SEAMS). Materials Methods: A cross-sectional was conducted major cardiology settings capital Sofia Burgas, fourth largest city Bulgaria. Data were collected from January 2024 July 2024. SEAMS...
Introduction Meaningful patient involvement in health technology assessment (HTA) is essential ensuring that the interests of affected population, their families, and general public are accurately reflected coverage reimbursement decisions. Central Eastern European (CEE) countries generally at less advanced stages implementing HTA, which particularly true for activities. As part Horizon2020 HTx project, this research aimed to form recommendations critical barriers HTA CEE countries. Methods...
Background: Rising expenditure for new cancer medicines is accelerating concerns that their costs will become unsustainable universal healthcare access. Moreover, early market access of oncology lacking appropriate clinical evaluation generates uncertainty over cost-effectiveness and increases unknown health gain. Patient-level data can complement trials generate better evidence on the effectiveness, safety outcomes these in routine care. This support policy decisions including funding....
Background: Acromegaly and its comorbidities affect the patients' quality of life, each healthcare system society. This study aimed to evaluate clinical characteristics treatment patterns economic burden acromegaly. Materials methods: All patients with acromegaly treated expensive medicines regularly followed up at main expert center for in country were included this nationwide, retrospective, observational, population-based study. Patient characteristics, patterns, resource use, costs...
The growth of public expenditure worldwide has set the priority on assessment trends and establishment factors which generate most significant costs. goal current study is to review tendencies in healthcare expenditures Bulgaria analyze influence demographic, economic, system capacity indicators dynamics. A retrospective, top-down, financial analysis was performed. Datasets National Statistical Institute (NSI), Health Insurance Fund (NHIF), Center Public Analysis (NCPHA) were retrospectively...
Introduction Breast cancer is the most common type of affecting women in Europe. Advanced breast (ABC) poses a significant therapeutic challenge, and therefore, timely access to treatment crucial. The aim present study was evaluate patterns patients' new therapies for ABC Bulgaria. Methods We conducted retrospective period 2008–2021. Based on European Medicines Agency (EMA) database, we analyzed number medicinal products with marketing authorization last 13 years. Time market evaluated as...
Objective Hypertension is one of the most common chronic diseases, affecting more than 20 % population. The side effects experienced due to antihypertensive medications such as tired-ness, muscle pain, and insomnia are often a significant predictor poor adherence therapy. goal current study present frequency, type, seriousness, severity adverse drug reactions reported BDA via Individual Case Safety Reports (ICSR) following differentiation messages found in patient. Methods We conducted...
Objective: Hypertensionis one of the most common chronic diseases, affecting more than 20% population. The side effects experienced due to antihypertensive medications, such as tiredness, muscle pain, and insomnia, are often a significant predictor poor adherence therapy. goal current study is present frequency, type, seriousness, severity adverse drug reactions reported BDA via Individual Case Safety Reports (ICSRs) following differentiation messages found in patient. Methods: We conducted...
The aim of this study is to evaluate the effect introduction biosimilars in Bulgaria on prices and utilization biologic disease modifying antirheumatic drugs (bDMARD). It a combined qualitative quantitative analysis time entry national market respective changes during 2015–2020. We found 58 for 16 reference products authorized sale European by end 2019, but 2 were not market. Only inflammatory joint had more than one biosimilar molecule indicated therapy. Prices observed bDMARD decreased 17%...
Patients' perspectives are important to identify preferences, estimate values and appreciate unmet medical needs in the process of research development subsequent assessment new health technologies. Patient public involvement technology (HTA) is essential understanding assessing wider implications coverage reimbursement decisions for patients, their relatives, caregivers, general population. There two approaches incorporating patients' voice HTA, preferably used a mix. In first one,...
Central and Eastern European countries (CEEC) have among the highest rates of increase in healthcare expenditure. External reference pricing, generics biologics price capping, regressive scale for setting, health technology assessment (HTA), positive drug lists reimbursed medicines are variety implemented cost-containment measures aimed at reducing controlling rising cost pharmaceuticals. The aim our study was to analyze influence a recently introduced measure Bulgaria—budget capping terms...
Health care systems worldwide are experiencing tremendous financial pressure because of the introduction new targeted health technologies and medicines. This study aims to analyze compare public household healthcare expenditures in Bulgaria during period 2015–2019, as well present major cost-containment measures implied by government their probable influence on overall cost. Regulatory analysis endorsed measures, budget expenditures, extrapolations were performed. The regulatory reveals that...
There is a global call for action cervical cancer elimination as public health problem—WHO Strategy 90-70-90. One of the strategic pillars, alongside vaccination, screening. This aims to assess economic consequences and cost-effectiveness primary DNA-HPV testing screening in Bulgaria. Combined (CEA) cost-benefit (CBA) analysis was performed evaluate net benefit HPV genotype program among women aged 30–54 Bulgaria compare its with current practice. ICER presented separately only direct costs...
Adherence is the degree to which patient's behaviour and actions correspond physician's established treatment regimen regarding timing, dose frequency. Patient counselling by both oncologists pharmacists optimization of therapeutic can critically impact decision-making adherence therapy. We performed a two-step study identify factors influencing therapy from perspective oncology hospital in Bulgaria. The results show that major affecting anticancer are manifestation adverse drug reactions...
This study aimed to investigate the transferability of novel artificial intelligence (AI) methods for prediction modelling diabetes based on real-world data (RWD) between early and late adopters emerging health technologies from perspective developers technology assessment (HTA) experts. A two-step approach was used. Developers new AI within HTx consortium completed a survey about benefits, usability, barriers associated with implementing models in routine HTA practices. Then, experts...