A5083181530- Pituitary Gland Disorders and Treatments
- Adrenal and Paraganglionic Tumors
- Growth Hormone and Insulin-like Growth Factors
- Neuroendocrine Tumor Research Advances
- Ophthalmology and Eye Disorders
- Hormonal Regulation and Hypertension
- Nutrition, Genetics, and Disease
- Neuroblastoma Research and Treatments
- Genetic Associations and Epidemiology
- Medication Adherence and Compliance
- Biomedical Research and Pathophysiology
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Parathyroid Disorders and Treatments
- Cardiovascular, Neuropeptides, and Oxidative Stress Research
- Neurofibromatosis and Schwannoma Cases
- Ion Transport and Channel Regulation
- Atherosclerosis and Cardiovascular Diseases
- Vitamin K Research Studies
- Diet and metabolism studies
- Human Health and Disease
- Thyroid Disorders and Treatments
- Cardiac tumors and thrombi
- Cellular transport and secretion
- Cardiovascular Disease and Adiposity
- Adrenal Hormones and Disorders
Medical University of Sofia
2012-2025
University Specialized Hospital for Active Treatment of Endocrinology
2017-2022
Sofia University "St. Kliment Ohridski"
2022
New Bulgarian University
2014
Centre Hospitalier Universitaire de Liège
2010-2011
University of Liège
2009-2011
Abstract Objective The variant 9p21 is correlated with coronary artery disease (CAD) in multiple studies the European population, but we lack information for Eastern Europeans (Caucasian). We aimed at investigating potential association of six common polymorphic variants locus (rs7865618, rs1537378, rs7857345, rs10757274, rs2383206, and rs10757278) CAD Bulgarian population. Materials methods current analysis included 261 patients angiographically documented (153 myocardial infarction 108...
Mortality in acromegaly strictly depends on optimal control of GH and IGF1 levels. Modern medical therapy with somatostatin analogs (SSAs) receptor antagonists (GHRAs) is not available many countries due to funding restrictions. This retrospective, comparative, cohort study investigated the impact different treatment modalities disease (GH IGF1) mortality patients.Two cohorts patients from Bulgaria (n=407) Campania, Italy (n=220), were compared, rates evaluated during a 10-year period...
We described biochemical outcome in regards to different treatment modalities patients with acromegaly Bulgaria.It was a retrospective analysis using data from the Bulgarian Acromegaly Database. Patients eligible on at least one modality were included study. Disease control assessed by both GH and IGF-1 values or GH/IGF-1 alone cases marker. Last follow-up median 7.0 (range 0.5-51) years after diagnosis.We identified 534 interpretable data, 65.4% of whom females. Overall surgical cure rate...
Background: Acromegaly and its comorbidities affect the patients' quality of life, each healthcare system society. This study aimed to evaluate clinical characteristics treatment patterns economic burden acromegaly. Materials methods: All patients with acromegaly treated expensive medicines regularly followed up at main expert center for in country were included this nationwide, retrospective, observational, population-based study. Patient characteristics, patterns, resource use, costs...
The purpose was to assess the level of medication adherence (MA) and related factors among individuals with acromegaly. secondary goal quality life patients whether how it correlates adherence. A prospective one-year study conducted acromegaly diagnosed, treated, monitored in reference center for rare endocrine diseases Bulgaria 2021. Clinical data, reported outcomes, health economics data were collected define predictors non-adherence medicines. Medication assessed through a free...
Endothelial dysfunction is a common feature of hypertension and associated with reduced nitric oxide bioavailability. The endogenous inhibitor syntase, asymmetric dimethylarginine (ADMA), soluble adhesion molecules such as vascular cell molecule 1 (sVCAM-1) have been established markers endothelial in number pathologic conditions including essential hypertension. There little information, however, about these endocrine To investigate the levels circulating ADMA sVCAM-1 patients...
Acromegaly is characterized by high neoplastic morbidity as a side effect of growth hormone (GH) hypersecretion. Increased incidence goiter, thyroid carcinoma, and dysfunction also reported. The aim the present study was to find prevalence goiter in patients with acromegaly determine its relationship disease activity, duration, presence secondary hypothyroidism.In cross-sectional period 2008-2012 were included 146 (56 men, 90 women) mean age 50.3 ± 12.4 years. activity function evaluated all...
Recent studies have revealed a higher rate of cardiovascular complications in primary aldosteronism (PA) compared to patients with essential hypertension (EH). Asymmetric dimethylarginine (ADMA) is marker endothelial dysfunction that could contribute increased risk PA.The aim this study was compare the levels ADMA among PA, controls EH and healthy participants. Methods: Serum were determined, using commercially available competitive enzyme-linked immunosorbent assay.Serum assay.Patients PA...
Genetic disorders of calcium metabolism arise in a familial or sporadic setting. The calcium-sensing receptor (CASR) plays key role maintaining homeostasis and study the CASR gene can be clinically useful determining etiology appropriate therapeutic approaches. We report two cases novel mutations that illustrate varying clinical presentations discuss these terms current understanding function.A 16-year-old patient had mild hypercalcemia associated with low-normal urinary excretion...
Acromegaly is a chronic disorder characterized by increased morbidity and mortality in uncontrolled patients. Growth hormone-secreting pituitary adenoma the hallmark majority of cases, generally considered as benign due to lack distant metastases. However, clinical behavior certain proportion these adenomas could be quite aggressive, causing difficulties their management. Aggressive have some clinical, radiological, ultrastructural molecular features common they are usually resistant...
Background: Adherence to therapy is one of the most important elements during therapeutic process ensuring predefined outcomes. The aim analyze need and importance treatment adherence guideline for acromegaly patients possibilities its development implementation in Bulgaria. Methods: A set methods was applied: (1) a literature review electronic database identification articles guidelines related acromegaly; (2) analysis Bulgarian legislative documents; (3) pilot study assessment level among...
<ns4:p>We describe a patient with rare combination of acromegaly and primary aldosteronism. A 37 year-old female was diagnosed on the basis typical clinical, hormonal image characteristics. She presented also one most common co-morbidities – arterial hypertension. The has been regularly followed-up after three surgical interventions, irradiation adjuvant treatment dopamine agonist, finally controlled in 2008 (20 years diagnosis). Arterial hypertension however, remained therapeutic problem...
We describe a patient with rare combination of acromegaly and primary aldosteronism. A 37 year-old female was diagnosed on the basis typical clinical, hormonal image characteristics. She presented also one most common co-morbidities - arterial hypertension. The has been regularly followed-up after three surgical interventions, irradiation adjuvant treatment dopamine agonist, finally controlled in 2008 (20 years diagnosis). Arterial hypertension however, remained therapeutic problem even...