A5102745564- Acute Myeloid Leukemia Research
- Cancer Genomics and Diagnostics
- Multiple Myeloma Research and Treatments
- Chronic Myeloid Leukemia Treatments
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Immunotherapy and Immune Responses
- Immune Cell Function and Interaction
- Chronic Lymphocytic Leukemia Research
- Protein Degradation and Inhibitors
- Epigenetics and DNA Methylation
- Hematopoietic Stem Cell Transplantation
- Peptidase Inhibition and Analysis
- Cancer Treatment and Pharmacology
- CAR-T cell therapy research
- Acute Lymphoblastic Leukemia research
- Head and Neck Cancer Studies
- Adrenal and Paraganglionic Tumors
- Histone Deacetylase Inhibitors Research
- T-cell and B-cell Immunology
- Lymphoma Diagnosis and Treatment
- Diet and metabolism studies
- Adrenal Hormones and Disorders
- Radiomics and Machine Learning in Medical Imaging
- Traditional Chinese Medicine Studies
- Platelet Disorders and Treatments
Chonnam National University Hwasun Hospital
2012-2024
Chonnam National University Hospital
2007-2023
University of Toronto
2019-2023
Chonnam National University
2005-2022
Palmetto Hematology Oncology
2011
Donor clonal hematopoiesis may be transferred to the recipient through allogeneic hematopoietic stem cell transplantation (HSCT), but potential for adverse long-term impact on transplant outcomes remains unknown. A total of 744 samples from 372 recipients who received HSCT and corresponding donors were included. Bar-coded error-corrected sequencing using a modified molecular inversion probe capture protocol was performed, which targeted 33 genes covering mutations involved in with...
The abundance, dynamics, and context-dependent heterogeneity of DNA methylation - where a pattern considered abnormal in one cell type may be normal another poses challenges identifying abnormalities linked to disease risk. Through genome-wide analyses, we identified CpG sites with remarkably consistent profiles healthy whole blood, predominantly existing an unmethylated state. We examined alterations at these epigenetically stable loci diverse cohorts, including those cardiovascular...
Hepatitis C virus (HCV) has the ability to persist in majority of infected people. Strong, multispecific and sustained T-cell response is correlated with viral clearance. The mechanisms chronicity by HCV are unclear. could restrain immune system establish chronic infection modulating dendritic cell (DC) function, function or both. DC dysfunction been postulated be either due direct presence proteins. In this report, for first time, we have examined whether soluble proteins can impair...
Purpose This study was performed to determine the feasibility and safety of use induction chemotherapy combined with docetaxel, cisplatin, 5-fluorouracil (TPF) followed by concurrent chemoradiation therapy for locally advanced squamous cell carcinoma head neck (SCCHN). Materials Methods The patients, that were initially not treated SCCHN, underwent three cycles every 3 weeks at a dose 70 mg/m2 docetaxel D1, 75 cisplatin 1000 5-FU D1-4, subsequently received therapy. Results Forty-nine...
Abstract Decrease in DNA dioxygenase activity generated by TET2 gene family is crucial myelodysplastic syndromes (MDS). The general downregulation of 5-hydroxymethylcytosine (5-hmC) argues for a role demethylation MDS beyond mutations, which albeit frequent, do not convey any prognostic significance. We investigated TETs expression to identify factors can modulate the impact mutations and thus 5-hmC levels on clinical phenotypes prognosis patients. DNA/RNA-sequencing data were collected from...
Abstract DNA sequencing-based measurable residual disease (MRD) detection has shown to be clinically relevant in AML. However, the same methodology cannot applied fusion gene-driven subtypes of AML such as core-binding factor (CBF-AML). Here this study, we evaluated effectiveness using and RNA sequencing MRD tracking clonal dynamics CBF-AML. Using RNA-seq, were able quantify expression levels RUNX1 - RUNX1T1 CBFB MYH11 at diagnosis their reduction during remission (P < 6.3e−05 P 2.2e−13)....
Multiple myeloma is an incurable and slow growing plasma cell neoplasm. The introduction of new drugs has increased the number treatment options. Bortezomib, first-in-class proteasome inhibitor, been shown to have a significant antitumor activity in relapse/refractory patients with multiple myeloma. Additionally, plasmacytomas response bortezomib. In this case report, we describe patient who developed disseminated fulminant extramedullary during combination chemotherapy bortezomib within...
Some bacterial and viral infections may reduce the risk of atopy, this is based on concept their ability to divert immune system towards Th1 responses. Most hepatitis B virus (HBV) occur in developing countries where atopic disorders are least prevalent. responses important for clearance HBV also antibody production. The aim study investigate whether presence antibodies surface antigen (anti-HBs) inversely associated with atopy adults.A random sample 358 subjects, who were without antigen,...