A5072772018- Bone Tissue Engineering Materials
- Osteoarthritis Treatment and Mechanisms
- Chemical Synthesis and Analysis
- Marine Biology and Environmental Chemistry
- Supramolecular Self-Assembly in Materials
- Wound Healing and Treatments
- Nanoparticle-Based Drug Delivery
- Polymer Surface Interaction Studies
- Inflammatory mediators and NSAID effects
- Cancer-related molecular mechanisms research
- Graphene and Nanomaterials Applications
- Dental Implant Techniques and Outcomes
- Spondyloarthritis Studies and Treatments
- Liver physiology and pathology
- RNA modifications and cancer
- Silk-based biomaterials and applications
- Cardiac Ischemia and Reperfusion
- Electrospun Nanofibers in Biomedical Applications
- Sirtuins and Resveratrol in Medicine
- Nanocomposite Films for Food Packaging
- Periodontal Regeneration and Treatments
- Cellular Mechanics and Interactions
- Aerogels and thermal insulation
- Advanced Glycation End Products research
- Mesoporous Materials and Catalysis
University of Chinese Academy of Sciences
2023-2025
Wenzhou Medical University
2022-2025
First Affiliated Hospital of Wenzhou Medical University
2023-2025
Zhengzhou University
2024
Tongji University
2024
Quzhou City People's Hospital
2024
Zhuhai People's Hospital
2024
Hangzhou Normal University
2020
Defective diabetic wound healing is a major clinical challenge, where hyperglycemia at the site induces excessive reactive oxygen species (ROS) which activate MAPK pathway (particularly p38 MAPK), resulting in sustained release of inflammatory factors and cellular damage/apoptosis. Polyphenols are efficient ROS scavengers reduce level inflammation promote healing, but low bioavailability limits their biomedical application. This study developed simple highly method for preparing...
Utilizing complementary bioactive peptides is a promising surface engineering strategy for bone regeneration on osteogenesis. In this study, we designed block peptides, (Lysine)
The limited osteointegration often leads to the failure of implant, which can be improved by fixing bioactive molecules onto surface, such as arginyl-glycyl-aspartic acid (RGD): a cell adhesion motif. Metal-Phenolic Networks (MPNs) have garnered increasing attention from different disciplines in recent years due their simple and rapid process for depositing on various substrates or particles with shapes. However, lack cellular binding sites MPNs greatly blocks its application tissue...
Abstract Osteointegration, the effective coupling between an implant and bone tissue, is a highly intricate biological process. The initial stages of bone‐related immunomodulation cellular colonization play crucial roles, but have received limited attention. Herein, novel supramolecular co‐assembled coating strontium (Sr)‐doped metal polyphenol networks (MPN) modified with c(RGDfc) developed well‐characterized, for eliciting early colonization. results showed that (Sr‐MPN)@RGD significantly...
Abstract Collagen, commonly used in tissue engineering, is widespread various tissues. During bone regeneration, collagen can stimulate the cellular response and determine fate of cells. In this work, we integrated type II with procyanidin (PC) onto an implant coating by applying a layer-by-layer technique to demonstrate that PC participate construction new biomaterials serve as multifunctional components. The effects PC/collagen multilayers on viability cocultured marrow mesenchymal stem...
The development of drug delivery systems with real-time cargo release monitoring capabilities is imperative for optimizing nanomedicine performance. Herein, we report an innovative self-reporting platform based on a ROS-responsive random copolymer (P1) capable visualizing kinetics via the activation integrated fluorophore. P1 was synthesized by copolymerization pinacol boronate, PEG, and naphthalimide monomers to impart ROS-sensitivity, hydrophilicity, fluorescence signaling, respectively....
Osteonecrosis of the femoral head (ONFH) is a condition caused by disruption or damage to head's blood supply, which causes death bone cells and marrow components prevents future regeneration. Ferroptosis, type controlled cell death, iron‐dependent lipid peroxidation. Here, we identified ferroptosis‐related genes infiltrating immune involved in ONFH predicted underlying molecular mechanisms. The GSE123568 dataset was subjected differential expression analysis identify related ferroptosis....
Abstract Osteoarthritis (OA) is a common chronic inflammatory disease that leads to disability and death. Existing therapeutic agents often require frequent use, which can lead drug resistance long‐term side effects. Polyphenols have anti‐inflammatory antioxidant potential. However, they are limited by their short half‐life low bioavailability. This work presents novel pure polyphenol capsule for sustained release of polyphenols, self‐assembled via hydrophobic hydrogen bonds. The enhances...
Aims This study was performed to explore the effect of melatonin on pyroptosis in nucleus pulposus cells (NPCs) and underlying mechanism that effect. Methods experiment included three patients diagnosed with lumbar disc herniation who failed conservative treatment. Nucleus tissue isolated from these when they underwent surgical intervention, primary NPCs were cultured. Western blotting, reverse transcription polymerase chain reaction, fluorescence staining, other methods used detect changes...
This study introduces the optimization of boronic ester-based ROS-responsive amphiphilic copolymers for antioxidant drug delivery.
Abstract Polyphenols and peptides represent two fundamental building blocks in the kingdom of supramolecular assembly (SA) coatings, which have recently attracted considerable interest. Regulating kinetics SA coatings is critical to controlling performance but this area still its infancy, especially coating peptide‐polyphenol. Herein, a library oligopeptides with rich diversity, numerous polyphenols, modulators are explored reveal their roles formation regulation coating. Citric acid (CA) an...
Implantable catheters are susceptible to severe complications due non-specific protein adhesion on their surfaces. Polyethylene glycol (PEG) coatings, the gold standard for resistance adhesion, present a challenge in achieving high-density grafting, which significantly restricts use as anti-biofouling coatings. Herein, we exploited strong interaction between polyphenols (PCs) and polycations (K6-PEG) graft PEG onto surface of PC-Cu (A network metal composed proanthocyanidins copper ions,...
<title>Abstract</title> Implantable catheters are susceptible to severe complications due non-specific protein adhesion on their surfaces. Polyethylene glycol (PEG) coatings, the gold standard for resistance adhesion, present a challenge in achieving high-density grafting, which significantly restricts use as anti-biofouling coatings. Herein, we exploited strong interaction between polyphenols (PCs) and polycations (K6-PEG) graft PEG onto surface of PC-Cu (A network metal composed...
Osteoarthritis is a very common clinical disease in middle-aged and elderly individuals, with the advent of ageing, incidence this gradually increasing. There are few studies on role basement membrane (BM)-related genes OA.We used bioinformatics machine learning methods to identify important related BMs OA patients performed immune infiltration analysis, lncRNA‒miRNA-mRNA network prediction, ROC qRT‒PCR.Based results learning, we determined that LAMA2 NID2 were key diagnostic OA, which...
The purpose of this study was to explore the mechanism exogenous MIF (macrophage migration inhibitory factor) in reducing apoptosis mouse BMSCs (bone marrow mesenchymal stem cells) induced by irradiation under high oxidative stress. Methods: were plated 60-mm culture dishes, and exposed radiation at a dose rate 1.02 Gy/min build cell damage model. Real-time quantitative polymerase chain reaction (RT-qPCR), western blot immunofluorescence used detect expression gene mRNA protein BMSCs....