A5043330477- Gallbladder and Bile Duct Disorders
- Pancreatic and Hepatic Oncology Research
- Pancreatitis Pathology and Treatment
- Pediatric Hepatobiliary Diseases and Treatments
- Esophageal and GI Pathology
- Gastrointestinal disorders and treatments
- Eosinophilic Esophagitis
- Dysphagia Assessment and Management
- Biliary and Gastrointestinal Fistulas
- Cardiac, Anesthesia and Surgical Outcomes
- COVID-19 Clinical Research Studies
- Enhanced Recovery After Surgery
- Abdominal Surgery and Complications
- Gastroesophageal reflux and treatments
- Gastrointestinal Bleeding Diagnosis and Treatment
- Frailty in Older Adults
- Cancer survivorship and care
- Colorectal Cancer Surgical Treatments
- Chronic Lymphocytic Leukemia Research
- Vascular Malformations and Hemangiomas
- Sphingolipid Metabolism and Signaling
- Gut microbiota and health
- Nutrition and Health in Aging
- Esophageal Cancer Research and Treatment
- Lymphoma Diagnosis and Treatment
Wake Forest University
2018-2025
Atrium Health Wake Forest Baptist
2017
Vanderbilt University Medical Center
2015
Background and Objectives Frailty disproportionately impacts older patients with gastrointestinal cancer, rendering them at increased risk for poor outcomes. A frailty index may aid in preoperative stratification. We hypothesized that high modified (mFI) scores are associated adverse outcomes after tumor resection older, cancer patients. Methods Patients (60‐90 years old) who underwent were identified the 2005‐2012 NSQIP Participant Use File. mFI was defined by 11 previously described,...
Disconnected pancreatic duct syndrome (DPDS) is the most common cause of fluid collection (PFC) recurrence. While long-term transmural drainage with plastic stents preferred endoscopic approach, there a paucity literature on patients undergoing initial lumen-apposing metal (LAMS). We describe our experience managing DPDS.A retrospective review prospectively maintained database (November 2015-September 2020) was performed looking at clinical outcomes and overall survival for management PFCs...
Background: Walled-off necrosis (WON) is a sequela of acute necrotizing pancreatitis preferentially managed with lumen apposing metal stents (LAMS). Adverse events including buried stent syndrome and bleeding have been associated longer duration LAMS placement. Objectives: We attempt to examine our outcomes standardized approach dwell time hypothesize that removal based on imaging characteristics patient symptoms improves outcomes. Design: From November 2015 May 2022, prospectively...
Advancements in the endoscopic management of walled-off necrosis using lumen apposing metal stents have improved outcomes over its surgical and percutaneous alternatives. The ideal procedural technique timing direct necrosectomy (DEN) yet to be clarified.From November 2015 June 2021, a retrospective comparative cohort analysis was performed comparing clinical for patients undergoing immediate DEN (iDEN) versus delayed (dDEN). Subgroups were identified based on quantification necrosis....
Abstract Background and study aims Cystic duct stones (CDS) are challenging to treat with conventional ERCP techniques due the small diameter tortuous nature of cystic duct. There have been limited studies focused on endoscopic management CDS. We present our experience managing CDS endoscopically demonstrate that new advances in technology rendered easier manage. Patients methods From 2013 2020, we prospectively maintained a database patients undergoing was performed all patients, if...
Endoscopic ultrasound-guided hepaticogastrostomy (EUS-HG) is a technique used to access the biliary tree in patients with surgically altered anatomy. Additionally, development of EUS-HG fistula permits intraductal therapy, thereby preventing from requiring surgery or percutaneous transhepatic drainage (PTBD), thus decreasing morbidity. This clinical vignette describes an 83-year-old man history gangrenous cholecystitis cholecystectomy, partial gastrectomy, and Roux-en-Y gastrojejunostomy who...
Introduction: An abnormal infiltration of intraepithelial lymphocytes in the intestinal mucosa is described as microscopic enteritis (ME). ME a heterogeneous condition that can be found in, but not limited to, celiac disease, autoimmune disorders, food protein intolerance, parasitic infections, and NSAID use. Thus, an obvious cause difficult to elucidate requires thorough work up. We report case patient who was have thought secondary infiltrative T-cell promyelocytic leukemia (T-PLL). Case...
The central question I investigated in my research this semester was how the cholesterol and triglyceride metabolic pathways interact macrophages when levels are high. What factors prevent or enhance macrophage ability to regulate metabolism? We have preliminary evidence that excessive accumulation alters metabolism these cells. When cellular normal, primary site of hydrolysis is on surface macrophage. There, lipases hydrolyze triglycerides within triglyceride-rich lipoproteins glycerol...
Introduction: Gastrointestinal symptoms are common in SARS-CoV-2 infection. infects enterocytes and sheds feces up to seven months despite respiratory clearance. Persistent viral inflammation may contribute risk of future GI complications including bleed. The study objective was identify factors associated with bleeding within one year after COVID-19 diagnosis. We hypothesized that at presentation would be positively for a bleed event. Methods: conducted retrospective cohort using electronic...
Background and study aims Innovations in endoscopic management of pancreatic fluid collections (PFCs) using lumen apposing metal stents (LAMS) have rendered it a preferred approach for drainage PFCs. These advances not come without concern adverse events (AEs). We present our experience with LAMS PFCs analyze factors that contribute to LAMS-related AEs. Patients methods From November 2015 October 2021, retrospective analysis was performed patients undergoing LAMS. All AEs were classified as...
INTRODUCTION: Familial Mediterranean Fever (FMF) is a hereditary autoinflammatory disease characterized by recurrent episodes of fever and polyserosal inflammation. The non-specific symptoms FMF can mimic large variety diseases, particularly Crohn’s (CD), as both diseases affect the digestive tract, skin, joints. This manuscript presents case with clinical that closely resemble CD. CASE DESCRIPTION/METHODS: A 28-year-old female Melkerson-Rosenthal syndrome presented to Wake Forest Digestive...