A5068268225- Cellular Mechanics and Interactions
- Hippo pathway signaling and YAP/TAZ
- Zebrafish Biomedical Research Applications
- Developmental Biology and Gene Regulation
- Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
- Genomics and Chromatin Dynamics
- Immune cells in cancer
- Protein Degradation and Inhibitors
- Microtubule and mitosis dynamics
- Congenital heart defects research
- Ubiquitin and proteasome pathways
- RNA modifications and cancer
- Immune Cell Function and Interaction
- Photoreceptor and optogenetics research
- Lipid metabolism and biosynthesis
- Melanoma and MAPK Pathways
- Liver Disease Diagnosis and Treatment
- Inflammatory Bowel Disease
- Pancreatic function and diabetes
- Circadian rhythm and melatonin
- Liver physiology and pathology
- Wnt/β-catenin signaling in development and cancer
- Retinal Development and Disorders
- Single-cell and spatial transcriptomics
- Spaceflight effects on biology
Yamaguchi University
2017-2024
The University of Tokyo
2015-2019
Tokyo Medical and Dental University
2009-2016
Introduction: RRAS2, a member of the R-Ras subfamily Ras-like low-molecular-weight GTPases, is considered to regulate cell proliferation and differentiation via RAS/MAPK signaling pathway. Seven RRAS2 pathogenic variants have been reported in patients with Noonan syndrome; however, few functional analyses conducted. Herein, we report two who presented Noonan-like phenotype recurrent novel (p.Gly23Val p.Gly24Glu, respectively) results their analysis. Materials methods: Wild-type (WT) mutant...
Abstract Macrophages are versatile cells of the innate immune system that work by altering their pro- or anti-inflammatory features. Their dysregulation leads to inflammatory disorders such as bowel disease. We show macrophage-specific upregulation clock output gene and transcription factor E4BP4 reduces severity colitis in mice. RNA-sequencing single-cell analyses macrophages revealed increased expression an overall increase genes including Il4ra with a concomitant reduction...
During vertebrate embryogenesis, the liver develops at a precise location along endodermal primitive gut tube because of signaling delivered by adjacent mesodermal tissues. Although several molecules have been associated with formation, molecular mechanism that regulates specification is still unclear. We previously performed screen in medaka to isolate mutants impaired development. The hio exhibit profound (but transient) defect resembles formation found zebrafish prometheus (prt) mutants,...
Abstract Stress‐induced Sapk/Jnk signaling is involved in cell survival and apoptosis. Recent studies have increased our understanding of the physiological roles Jnk embryonic development. However, still unclear precise function during gastrulation, a critical step establishment vertebrate body plan. Here we use morpholino‐mediated knockdown zebrafish orthologs activators Mkk4 Mkk7 to examine effect abrogation on early embryogenesis. Depletion Mkk4b led abnormal convergent extension (CE)...
Abstract The pineal gland functioning as a photoreceptive organ in non-mammalian species is serial homolog of the retina. Here we found that Brain-specific homeobox (Bsx) key regulator conferring individuality on between two serially homologous organs zebrafish. Bsx knock-down impaired development with reduced expression exorh , pineal-specific gene responsible for photoreception, whereas it induced ectopic rho retina-specific gene, gland. remarkably transactivated promoter combination Otx5,...
Ewing's sarcoma is the second most common bone malignancy in children or young adults and caused by an oncogenic transcription factor a chromosomal translocation between EWSR1 gene ETS family. However, transcriptional mechanism of EWS-ETS fusion proteins still unclear. To identify complexes factors, we applied proximal labeling system called BioID cells. We identified AHDC1 as protein proteins. knockdown showed reduced cell growth activity EWS-FLI1. also BRD4 BRG1 levels, both known...
c-Jun N-terminal...
<title>Abstract</title> Macrophages are versatile cells of the innate immune system that work by altering their pro- or anti-inflammatory features. Their dysregulation leads to inflammatory disorders such as bowel disease. We show macrophage-specific upregulation clock output gene and transcription factor E4BP4 reduces severity colitis in mice. RNA-sequencing single-cell analyses macrophages revealed increased expression an overall increase genes including Il4ra with a concomitant reduction...
Abstract Ewing’s sarcoma is the second most common bone malignancy in children or young adults and caused by an oncogenic transcription factor a chromosomal translocation between EWSR1 gene ETS family. However, transcriptional mechanism of EWS-ETS fusion proteins still unclear. To identify complexes factors, we applied proximal labeling system called BioID cells. We identified AHDC1 as protein proteins. knockdown showed reduced cell growth activity EWS-FLI1. also BRD4 BRG1 levels, both known...