A5051227076- Pregnancy and preeclampsia studies
- Gestational Diabetes Research and Management
- Endometrial and Cervical Cancer Treatments
- Birth, Development, and Health
- Prenatal Screening and Diagnostics
- Ovarian cancer diagnosis and treatment
- Maternal and fetal healthcare
- Uterine Myomas and Treatments
- Pregnancy-related medical research
- Preterm Birth and Chorioamnionitis
- Bariatric Surgery and Outcomes
- Endometriosis Research and Treatment
- Renal and Vascular Pathologies
- Parathyroid Disorders and Treatments
- Neurological Complications and Syndromes
- Cardiovascular Issues in Pregnancy
- Hemoglobinopathies and Related Disorders
- Cerebral Venous Sinus Thrombosis
- Chronic Kidney Disease and Diabetes
- Intestinal and Peritoneal Adhesions
- Estrogen and related hormone effects
- Assisted Reproductive Technology and Twin Pregnancy
- Gynecological conditions and treatments
- Medical Imaging and Pathology Studies
- Dialysis and Renal Disease Management
Royal Women's Hospital
2014-2025
The University of Melbourne
2017-2025
Epworth Hospital
2024
Geelong Hospital
2012
Objective To identify effects on health outcomes from implementing new criteria diagnosing gestational diabetes mellitus(GDM) and to analyse costs-of-care associated with this change. Design Quasi-experimental study comparing data the calendar year before (2014) after (2016) Setting Single, tertiary-level, university-affiliated, maternity hospital. Participants All women giving birth in hospital, excluding those pre-existing or multiple pregnancy. Main outcome measures Primary were caesarean...
Fetal growth restriction secondary to chronic placental insufficiency is a major cause of perinatal morbidity and mortality. A significant proportion fetuses with fetal are small for gestational age, defined as birthweight ≤10th percentile. However, not all small-for-gestational-age restricted. Some constitutionally otherwise healthy. It important distinguish between without ensure appropriate interventions in minimize unnecessary healthy fetuses. The maternal serum ratio soluble fms-like...
Premenopausal women with early endometrial cancer may wish to maintain their fertility, and for some patients non-surgical treatment options be attractive. We have examined our own experience such patients, as there are limited published data so far support clear guidelines in this area.Retrospective analysis of a case series.Case series from specialist gynaecological oncology unit major tertiary referral hospital.Sixteen receiving progestogen therapy stage-1 cancer.We reviewed all cancer,...
Background Cervical cerclage has been used as a treatment for cervical insufficiency over 60 years. Transabdominal is indicated not amenable to transvaginal procedure, or following previous failed vaginal cerclage. A laparoscopic approach abdominal offers the potential reduce morbidity associated with laparotomy. Aims To evaluate obstetric outcome and surgical of transabdominal Methods An observational study consecutive women undergoing from 2007 2013 by single surgeon (AA). Eligible had...
The Australasian Diabetes in Pregnancy Society recommends screening high-risk women for gestational diabetes mellitus (GDM) before 24 weeks gestation, under the assumption that an earlier diagnosis and opportunity to achieve normoglycemia will minimize adverse outcomes. However, little evidence exists this recommendation. study objective was compare pregnancy outcomes of diagnosed with GDM gestation routinely after gestation. A retrospective audit conducted all pregnancies using...
Abstract Aim To evaluate if maternal serum soluble fms‐like tyrosine kinase‐1(sFlt‐1) to placental growth factor (PlGF) ratio levels at term can anticipate the following adverse pregnancy outcomes: small for gestational age neonates; operative delivery suspected fetal welfare compromise; and neonatal compromise. Methods A retrospective analysis of a single hospital database containing antenatal kinase‐1 (sFlt‐1/PlGF) results together with associated demographic, clinical investigative...
Background Gestational diabetes (GDM) is one of the commonest pregnancy complications and placing an increasing burden on obstetric resources. Aims To describe different antenatal models care that have developed to address proportion pregnancies complicated by GDM. Materials Methods Narrative review with thematic analysis from 15 volunteer in services Australia New Zealand identified through a national organisation. Main outcomes were approaches patient education, medical nutrition therapy...
There has been an increasing interest in accurately assessing tumors preoperatively to plan appropriate surgery or, some low-risk patients, conservative treatment. We wish determine the accuracy of magnetic resonance imaging (MRI) predicting myometrial invasion endometrial cancer and whether it is a safe suitable tool for planning treatment.We compared MRI scans final histopathologic diagnoses 111 patients with endometrioid adenocarcinoma over 6-year period at major tertiary centre. Data...
Background The gold standard for diagnosis of proteinuria in pre‐eclampsia is traditionally a 24‐h urine collection. Current A ustralian guidelines advocate use the spot protein‐to‐creatinine ratio ( PCR ); however, there controversy international literature about its accuracy and little recent Australian data exists. Aim To clarify cohort women with pre‐eclampsia. Methods Women over 52‐month period from single obstetric unit were included study. Spot , collection, gestation at delivery,...
It has been suggested that the risk of adverse perinatal outcomes in twin pregnancies is exacerbated by concomitant gestational diabetes mellitus (GDM). This study aimed to assess incurred pregnancy and a diagnosis GDM, separately, on development poor outcomes. A retrospective cohort was conducted all pregnant women at tertiary center between 2016 2017. The impact GDM - birth weight above 90th centile for age, cesarean delivery, clinical neonatal hypoglycemia, premature delivery (before 37...
Pregnancy and caesarean section are known to predispose the development of acute colonic pseudo-obstruction (ACPO), a rare form functional ileus distal large bowel. Pathogenesis ACPO is likely influenced by pregnancy childbirth subsequent changes hormonal, autonomic metabolic physiology. Identifying risk factors will assist with early identification, as insidious onset postpartum often leads delayed diagnosis bowel ischaemia, perforation sepsis.To establish associated after section.A...
For select women with early endometrial cancer, particularly nulliparous women, nonsurgical options may be considered. There is increasing experience using progestogens, but little known about the long-term outcomes and safety of such treatment.To present cancer pregnancy greater than five years follow-up after progestogen treatment for cancer.Ten who underwent six months continuous therapy were included in study. All managed by a gynaecological oncologist at major tertiary centre Melbourne,...
Background . Current data on the rates of macrosomia in women with gestational diabetes mellitus (GDM) are heterogenous. No study has specifically examined diet-controlled diabetes. Aims To compare between mothers GDM to without mellitus. Methods A retrospective which all patients and singleton pregnancies 2014 were considered for inclusion study. These cases individually matched type 1 or 2 Cases parity, age, BMI. Controls selected from same year as close possible date delivery case....
A key focus of the Closing Gap campaign is to reduce low birthweight in Aboriginal babies. Limited research exists on factors affecting urban areas.Retrospective cohort analysis 38,382 births (38,167 non-Aboriginal, 215 Aboriginal) at Royal Women's Hospital Melbourne from January 2010 December 2015. status was defined by mothers who identified themselves and their baby as or Torres Strait Islander. The aim examine association maternal health risk behaviours obstetric complications with...
ABSTRACT Purpose Maternal ocular sonography offers a window into cerebrovascular and intracranial pressure changes in pregnancy. This study aimed to determine the Doppler velocimetric variables of ophthalmic artery, mean diameter optic nerve sheath (ONSD), an Australian cohort healthy pregnant women. Methods A prospective observational women with uncomplicated singleton pregnancies third trimester was undertaken tertiary maternity service. single prenatal ultrasonographic examination...
The prognostic significance of oestrogen and progesterone receptors (ER/PR) in endometrial stromal sarcoma (ESS) has conflicting reports the literature, routine use adjuvant progestogen is uncertain efficacy.To examine ER/PR positivity primary with outcome ESS.All women a diagnosis ESS our tertiary institution associated private practices over last 23 years were included. Primary variables use. Other included high-grade disease extrauterine disease. was survival, secondary recurrence-free...
A single umbilical artery (SUA) was identified in 1.5% of twin pregnancies. The presence a SUA pregnancy associated with 50% incidence fetal anomalies, many them complex and severe. embryology pathophysiological mechanisms are reviewed. Aneuploidy is relatively common should be considered, particularly the anomalies. Fetal growth restriction frequent preterm delivery common.
Gestational trophoblastic disease (GTD) is an uncommon but highly treatable condition. There limited local evidence to guide therapy.
To determine the prognosis of an isolated single umbilical artery (SUA) in a twin pregnancy, we selected pregnancies with second trimester ultrasound diagnosing SUA at least one fetus our tertiary hospital. This was confirmed by placental histopathology or expert review images. Cases were identified searching hospital database over period 7.5 years. Higher order multiples coexistent aneuploidy major anomalies excluded. Each case assigned three consecutive pregnancy controls paired for...
Background Insulin delivery options for pregnant women with type 1 diabetes mellitus are either continuous subcutaneous insulin infusion or multiple daily injections. The aim of this paper is to compare pregnancy outcomes in using injections pregnancy. Methods Retrospective single-centre cohort study 298 pregnancies booked between 2006 and 2016. Descriptive analysis was performed HbA1c values. Logistic regression models were created selected maternal neonatal outcomes. Results Continuous...
Reliably predicting spontaneous preterm birth remains challenging, therefore it persists as a major contributor to perinatal morbidity and mortality. The use of biomarkers predict premature cervical shortening, recognised risk factor for birth, is yet be fully explored in current literature. This study evaluates seven cervicovaginal biochemical possible predictors shortening. Asymptomatic, high-risk women (n = 131) presenting specialised prevention clinic were analysed through retrospective...
Calcium and phosphate are present in serum at concentrations that should encourage precipitation, but ectopic mineral deposition outside of osseous tissue is rarely seen children disease states. However, ageing some pathologies e.g. chronic kidney disease, inflammatory diabetes, extra-osseous common. For many years a high level has been considered one the prime drivers to this event, yet evidence modifying levels affects calcification lacking.