A5033406796- Metabolomics and Mass Spectrometry Studies
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Advanced Proteomics Techniques and Applications
- Immune Cell Function and Interaction
- Mass Spectrometry Techniques and Applications
- Immune cells in cancer
- IL-33, ST2, and ILC Pathways
- SARS-CoV-2 and COVID-19 Research
- Cell Adhesion Molecules Research
- Toxin Mechanisms and Immunotoxins
- Cancer Immunotherapy and Biomarkers
- Diet and metabolism studies
- Cannabis and Cannabinoid Research
- Virus-based gene therapy research
- Gut microbiota and health
- Immune Response and Inflammation
- Immunotherapy and Immune Responses
- Respiratory viral infections research
- Dermatology and Skin Diseases
- Inflammasome and immune disorders
- Psoriasis: Treatment and Pathogenesis
- T-cell and B-cell Immunology
Northwestern University
2022-2024
Northwestern University
2023
Center for Research and Advanced Studies of the National Polytechnic Institute
2020-2022
Instituto Politécnico Nacional
2022
Hospital Infantil de México Federico Gómez
2017-2020
Centro de Investigación en Materiales Avanzados
2017
Neutrophil (PMN) mobilization to sites of insult is critical for host defense and requires transendothelial migration (TEM). TEM involves several well-studied sequential adhesive interactions with vascular endothelial cells (ECs); however, what initiates or terminates this process not well-understood. Here we describe believe be a new mechanism where vessel associated macrophages (VAMs) through localized primed EC responses form ICAM-1 "hot spots", support PMN TEM. Using real-time intravital...
While immunotherapy has revolutionized cancer treatment, its safety been hampered by immunotherapy-related adverse events. Unexpectedly, we show that Mediator complex subunit 1 (MED1) is required for T regulatory (Treg) cell function specifically in the tumor microenvironment. Treg cell-specific MED1 deletion does not predispose mice to autoimmunity or excessive inflammation. In contrast, promotion of growth because terminal differentiation effector cells tumor. Suppression these terminally...
Ulcerative colitis (UC) is a chronic relapsing disease featuring aberrant accumulation of neutrophils in colonic mucosa and the luminal space. Although significant advances UC therapy have been made with development novel biologics small molecules targeting immune responses, success most current therapies still limited, safety concerns. Thus, there need to develop additional safe effective for treatment UC. Antimalarial drugs safely used many years resolve tissue inflammation associated...
Mucosal innate immunity functions as the first line of defense against invading pathogens. Members IL-1 family are key cytokines upregulated in inflamed mucosa. Inflammatory regulated by limiting their function and availability through activation secretion mechanisms. is affected lack a signal peptide on sequence, which prevents them from accessing conventional protein pathway; thus, they use unconventional pathways. Here we show mouse macrophages that LPS/ATP stimulation induces cytokine...
Because large brains are energetically expensive, they associated with metabolic traits that facilitate energy availability across vertebrates. However, the biological underpinnings driving these not known. Given its role in regulating host metabolism disease studies, we hypothesized gut microbiome contributes to variation normal cross-vertebrate species differences metabolism, including those brain’s energetic requirements. By inoculating germ-free mice microbiota (GM) of three primate –...
Mass spectrometry has been the focus of technology development and application for imaging several decades. Imaging mass using matrix-assisted laser desorption ionization is a new effective tool molecular studies complex biological samples such as tissue sections. As histological features remain intact throughout analysis section, distribution maps multiple analytes can be correlated with clinical features. Spatial arrangements assessed without need target-specific reagents, allowing...
T regulatory (Treg) cells engage specific transcriptional programs depending on the environmental and immunologic context. The Tregcell-intrinsic mechanisms differentially regulating these between tumors other inflammatory settings remain to be determined. Here we show that Mediator complex subunit 1 (MED1) is required for Treg cell function specifically in context of tumor microenvironment. cell-specific deletion MED1 did not predispose mice autoimmunity or affect models colitis,...