A5040362768- Advanced MRI Techniques and Applications
- Lanthanide and Transition Metal Complexes
- 3D Printing in Biomedical Research
- Neuroscience and Neural Engineering
- Medical Imaging Techniques and Applications
- Cardiomyopathy and Myosin Studies
- Supramolecular Self-Assembly in Materials
- interferon and immune responses
- Cardiac Imaging and Diagnostics
- Photoreceptor and optogenetics research
- Nanoplatforms for cancer theranostics
- Alzheimer's disease research and treatments
- Nanoparticle-Based Drug Delivery
- Effects of Radiation Exposure
- Cardiac Valve Diseases and Treatments
- Neuroscience and Neuropharmacology Research
- Advanced NMR Techniques and Applications
- Muscle Physiology and Disorders
- Neuroinflammation and Neurodegeneration Mechanisms
- MRI in cancer diagnosis
- Systemic Lupus Erythematosus Research
- COVID-19 Clinical Research Studies
- Viral Infections and Immunology Research
- Cardiac tumors and thrombi
- Cytokine Signaling Pathways and Interactions
University of South Carolina
2025
Northwestern University
2015-2024
Bradford Royal Infirmary
2023
Advanced Imaging Research (United States)
2021
University of Chicago
2017
Waters (United States)
2008-2016
Jesse Brown VA Medical Center
2010
University of Illinois Chicago
2010
Washington University in St. Louis
2004-2008
A Gd(III)-nanodiamond conjugate [Gd(III)-ND] was prepared and characterized, enabling detection of nanodiamonds by MR imaging. The Gd(III)-ND particles significantly reduced the T1 water protons with a per-Gd(III) relaxivity 58.82 ± 1.18 mM−1 s−1 at 1.5 T (60 MHz). This represents 10-fold increase compared to monomer Gd(III) complex (r1 = 5.42 0.20 s−1) is among highest relaxivities reported.
Small animals support a wide range of pathological phenotypes and genotypes as versatile, affordable models for pathogenesis cardiovascular diseases exploration strategies in electrotherapy, gene therapy, optogenetics. Pacing tools such contexts are currently limited to tethered embodiments that constrain animal behaviors experimental designs. Here, we introduce highly miniaturized wireless energy-harvesting digital communication electronics thin, pacing platforms weighing 110 mg with...
Temporary postoperative cardiac pacing requires devices with percutaneous leads and external wired power control systems. This hardware introduces risks for infection, limitations on patient mobility, requirements surgical extraction procedures. Bioresorbable pacemakers mitigate some of these disadvantages, but they demand pairing external, systems secondary mechanisms control. We present a transient closed-loop system that combines time-synchronized, wireless network skin-integrated an...
Ultrasmall (3, 4, 5, and 6 nm), water-soluble Fe
Measurements of regional internal body temperatures can yield important information in the diagnosis immune response-related anomalies, for precisely managing effects hyperthermia and hypothermia therapies monitoring other transient processes such as those associated with wound healing. Current approaches rely on permanent implants that require extraction surgeries after measurements are no longer needed. Emerging classes bioresorbable sensors eliminate requirements extraction, but their use...
Significance Monitoring neuronal activity with cell specificity in freely behaving animal models can yield insights into underpinning operating mechanisms of the brain. Dynamics genetically targeted populations be recorded through calcium indicators; however, current tools for such measurements are only available tethers or large and heavy externalized head stages, potential to influence behaviors test subjects limit experimental paradigms simple two-dimensional arenas. Here, we introduce...
Multiple imaging modalities are often required for in vivo applications that require both high probe sensitivity and excellent spatial temporal resolution. In particular, MR optical an attractive combination can be used to determine molecular anatomical information. Herein, we describe the synthesis testing of two multimeric NIR–MR contrast agents contain three Gd(III) chelates IR-783 dye moiety. One agent contains a PEG linker other short alkyl linker. These label cells with extraordinary...
Abstract Continuous, real-time monitoring of perfusion after microsurgical free tissue transfer or solid organ allotransplantation procedures can facilitate early diagnosis and intervention for anastomotic thrombosis. Current technologies including Doppler systems, cutaneous O 2 -sensing probes, fluorine magnetic resonance imaging methods are limited by their intermittent measurements, requirements skilled personnel, indirect interfaces, and/or tethered connections. This paper reports a...
Abstract In vivo optogenetics and photopharmacology are two techniques for controlling neuronal activity that have immense potential in neuroscience research. Their applications tether-free groups of animals been limited part due to tools availability. Here, we present a wireless, battery-free, programable multilateral optofluidic platform with user-selected modalities optogenetics, pharmacology photopharmacology. This system features mechanically compliant microfluidic electronic...
A one-pot reaction process was developed to synthesize highly dispersible, superparamagnetic Fe(3)O(4) nanoflowers; the potential of these nanoflowers as MRI contrast agents investigated.
The ability to track labeled cancer cells in vivo would allow researchers study their distribution, growth, and metastatic potential within the intact organism. Magnetic resonance (MR) imaging is invaluable for tracking as it benefits from high spatial resolution absence of ionizing radiation. However, many MR contrast agents (CAs) required label either do not significantly accumulate or are biologically compatible translational studies. We have developed carbon-based...
Bioactive supramolecular nanostructures are of great importance in regenerative medicine and the development novel targeted therapies. In order to use chemistry design such nanostructures, it is extremely important track their fate vivo through molecular imaging strategies. Peptide amphiphiles (PAs) known generate a wide array there extensive literature on areas as tissue regeneration therapies for disease. We report here series PA molecules based well-established β-sheet amino acid sequence...
Our lab has developed a new series of self-immolative MR agents for the rapid detection enzyme activity in mouse models expressing β-galactosidase (β-gal). We investigated two molecular architectures to create that detect β-gal by modulating coordination water GdIII . The first is an intermolecular approach, wherein we designed several structural isomers maximize endogenous carbonate ions. second involves intramolecular mechanism q modulation. incorporated pendant coordinating carboxylate...
Surgical options for relapsed clubfoot include repeat heel cord lengthening or posterior release recurrent equinus, and anterior tibialis tendon transfer (ATT) residual dynamic supination deformity. Some studies have suggested that these procedures be performed in isolation to allow early range of motion after intra-articular surgery. This study was examine clinical radiographic outcomes comparing two surgical methods, simultaneous ATT with (ATT/PR) vs (ATT(i)), the management Patients who...
Angiogenesis is a critical early feature of atherosclerotic plaque development and may also prominently in the pathogenesis aortic valve stenosis. It has been shown that MRI can detect quantify specific molecules interest expressed cardiovascular disease cancer by measuring unique fluorine signature appropriately targeted perfluorocarbon (PFC) nanoparticles. In this study, we demonstrated binding ανβ3 integrin nanoparticles to neovasculature rabbit model disease. We showed could be used...
Magnetic resonance imaging (MRI) has long been used clinically and experimentally as a diagnostic tool to obtain three-dimensional, high-resolution images of deep tissues. These are enhanced by the administration contrast agents such paramagnetic Gd(III) complexes. Herein, we describe preparation series multimodal in which complexes conjugated fluorescent tetrapyrrole, namely, porphyrazine (pz). Zinc metalated pzs one, four, or eight reported. Among these conjugates, Zn-Pz-8Gd(III) exhibits...
Improvements have been made in the diagnosis of Alzheimer's disease (AD), manifesting mostly development vivo imaging methods that allow for detection pathological changes AD by magnetic resonance (MRI) and positron emission tomography (PET) scans. Many these methods, however, use agents probe amyloid fibrils plaques-species do not correlate well with progression are present at earliest stages disease. Amyloid β oligomers (AβOs), rather, now widely accepted as Aβ species most germane to...
Cardiomyopathy and arrhythmias are under significant genetic influence. Here, we studied a family with dilated cardiomyopathy associated conduction system disease in whom prior clinical cardiac gene panel testing was unrevealing.Whole-genome sequencing induced pluripotent stem cells were used to examine atrial ventricular arrhythmias. We also characterized mouse model heterozygous homozygous deletion of Mybphl.Whole-genome identified premature stop codon, R255X, the MYBPHL encoding MyBP-HL...
Magnetic resonance imaging is a noninvasive modality with high spatial and temporal resolution. Contrast agents (CAs) are frequently used to increase the contrast between tissues of interest. To effectiveness MR agents, small molecule CAs have been attached macromolecules. We created family biodegradable, macromolecular based on protein polymers, allowing control over CA properties. The polymers monodisperse, random coil, contain evenly spaced lysines that serve as reactive sites for Gd(III)...
We demonstrate the ability of a molecular Fe<sub>2</sub> complex to enable magnetic resonance-based ratiometric quantitation redox status.
Abstract Real‐time detection of targeted contrast agent binding is challenging due to background signal from unbound agent. 19 F diffusion weighted MR spectroscopy (DWS) could selectively detect angiogenesis‐targeted perfluorocarbon nanoparticles in vivo. Transgenic K14‐HPV16 mice with epidermal squamous carcinomas exhibiting up‐regulated neovasculature were used, nontransgenic littermates as controls. Mice treated α v β 3 ‐integrin nanoparticles. DWS (b‐values 0 16,000 s/mm 2 ) was...