A5078866574- Paraoxonase enzyme and polymorphisms
- Cholesterol and Lipid Metabolism
- Antioxidant Activity and Oxidative Stress
- Cynara cardunculus studies
- Free Radicals and Antioxidants
- Nutrition and Health in Aging
- Alzheimer's disease research and treatments
- Cardiac Imaging and Diagnostics
- Atherosclerosis and Cardiovascular Diseases
- Fatty Acid Research and Health
- Neuroinflammation and Neurodegeneration Mechanisms
- Hibiscus Plant Research Studies
- Cerebrovascular and Carotid Artery Diseases
- Tryptophan and brain disorders
- Nutritional Studies and Diet
- Apelin-related biomedical research
- Lipoproteins and Cardiovascular Health
- Phytochemicals and Antioxidant Activities
- Pomegranate: compositions and health benefits
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Medical Imaging Techniques and Applications
- Cardiovascular Disease and Adiposity
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Peroxisome Proliferator-Activated Receptors
- Adipokines, Inflammation, and Metabolic Diseases
Université de Sherbrooke
2016-2025
Health and Social Services Centre University Institute of Geriatrics of Sherbrooke
2004-2023
Centre Hospitalier Universitaire de Sherbrooke
1999-2023
Minia University
2014-2021
Centre Intégré Universitaire de Santé et de Services Sociaux du Centre-Sud-de-l'Île-de-Montréal
2019
Military Hospital of Tunis
2017
Hôpital Fleurimont
2013-2016
King Saud University
1993-2014
Université Sultan Moulay Slimane
2007
Centre for Excellence in Mining Innovation
2006
Cardiovascular diseases (CVDs) have become the leading global cause of mortality, prompting a heightened focus on identifying precise indicators for their assessment and treatment. In this perspective, plasma levels HDL emerged as pivotal focus, given demonstrable correlation between cardiovascular events, rendering them noteworthy biomarker. However, it is crucial to acknowledge that HDLs, while intricate, are not presently direct therapeutic target, necessitating more nuanced understanding...
Alzheimer's disease (AD) is the most common neurodegenerative ultimately manifesting as clinical dementia. Despite considerable effort and ample experimental data, role of neuroinflammation related to systemic inflammation still unsettled. While implication microglia well recognized, exact contribution peripheral monocytes/macrophages largely unknown, especially concerning their in various stages AD.AD develops over decades its manifestation preceded by subjective memory complaints (SMC)...
Natural antioxidants products are widely distributed in food and medicinal plants. These natural antioxidants, especially polyphenols, exhibit a wide range of biological activities including anti-cancer, anti-inflammatory, anti-atherosclerosis activities. Pomegranate (Punica granatum L.) is rich source polyphenolic components. The purpose this study was to characterize the phenolic composition flavonoids anthocyanin content different parts (peel aril) Sefri variety pomegranate. Our results...
To compare sarcopenic-obese and obese postmenopausal women for risk factors predisposing to cardiovascular disease (CVD) determine whether there may be a relationship between muscle mass metabolic in women.In this cross-sectional study, 22 healthy (mean age, 66 +/- 5 years; mean BMI, 27 3 kg/m(2)) were divided into two groups matched age (+/-2 years) fat (FM) (+/-2%). Sarcopenia was defined as index of <14.30 kg fat-free (FFM)/m(2) (which corresponds 1 standard deviation below the values...
Aging is an important risk factor for cardiovascular diseases and convincing data have shown that chronic low-grade inflammation, which develops with advanced age, contributes significantly to risk. The present study aimed use 18F-FDG/18F-NaF-PET/CT imaging to, respectively, gauge arterial inflammation microcalcification in a healthy elderly population assess the potential benefits of tyrosol- hydroxytyrosol-rich diet on these two markers atherosclerotic plaque fragility. Eleven participants...
Abstract: Background: Aging is an important risk factor for cardiovascular diseases and con-vincing data has shown that chronic low-grade inflammation, which develops with advanced age, contributes significantly to risk. Objectives: The present study aimed use ¹⁸F-FDG/¹⁸F-NaF-PET/CT imaging respectively gauge arterial inflammation microcalcifi-cation in healthy elderly assess the potential benefits of a tyrosol- hydroxytyrosol-rich diet on these two markers atherosclerotic plaque fragility....
Abstract Aging is associated with a decline in T cell activation and proliferation, but the underlying mechanisms are not fully understood. Recent findings suggest that lipid rafts act as platform initiation of by selectively recruiting signaling proteins formation initial complex signal transduction. We tested hypothesis raft properties altered lymphocytes from elderly, healthy individuals comparison young subjects. Results showed cholesterol content derived these cells was consistently...
The aim of this study was to investigate the effect HDL oxidation on PON1 paraoxonase activity. Also, we were interested in investigating mechanism by which could be inactivated and correlation between its enzymatic activity antioxidant properties HDL. Three different systems used for oxidation: (1) induced THP1 cells, (2) copper ions at a concentration 10 microM, (3) *OH O2.- oxygen free radicals produced gamma-radiolysis. followed measurement lipid peroxide formation, determined measuring...
Paraoxonase 1 (PON1) is associated with HDL and modulates the antioxidant anti-inflammatory role of HDL. The goals present study were to investigate effect ageing PON1 on activity HDL, determine whether extra-virgin olive oil (EVOO) consumption could improve atheroprotective isolated from plasma ten young (Y-HDL Y-PON1) elderly (E-HDL E-PON1) healthy volunteers before after 12 weeks EVOO consumption. Inflammation was assessed by measuring intracellular adhesion molecule (ICAM-1) expression....
The present study was aimed to investigate the effect of 12 weeks extra-virgin olive oil (EVOO) consumption on capacity HDL promote cholesterol efflux (CE) and determine which CE pathways are modulated by EVOO consumption. Whole 2 /HDL 3 subclasses were isolated from plasma twenty-six healthy volunteers before after (25 ml/d). increased serum mediate THP-1, J774 macrophages Fu5AH cells 9·8–24·57 %, depending cell type. increase in independent both concentration subclass distribution. three...