A5082448281- Neuroscience of respiration and sleep
- Neonatal Respiratory Health Research
- Cardiac Ischemia and Reperfusion
- PARP inhibition in cancer therapy
- Restraint-Related Deaths
- Respiratory Support and Mechanisms
- Sirtuins and Resveratrol in Medicine
- Infant Health and Development
- Tuberculosis Research and Epidemiology
- Viral Infections and Immunology Research
- Cardiac electrophysiology and arrhythmias
- Nitric Oxide and Endothelin Effects
- Heart Rate Variability and Autonomic Control
- Neonatal and fetal brain pathology
- Cardiovascular Function and Risk Factors
- Heme Oxygenase-1 and Carbon Monoxide
- Non-Invasive Vital Sign Monitoring
- Connective tissue disorders research
- Respiratory and Cough-Related Research
- Clinical practice guidelines implementation
- Influenza Virus Research Studies
- Healthcare Technology and Patient Monitoring
- Calcium signaling and nucleotide metabolism
- Circadian rhythm and melatonin
- Sleep and Wakefulness Research
Meyer Children's Hospital
2007-2025
Istituti di Ricovero e Cura a Carattere Scientifico
2025
Meyer (China)
2022
University of Florence
2002-2012
Abstract Background: Although oxidative stress‐related diseases mostly affect neonates with extremely low birthweight, healthy preterm newborns might also be at risk of damages. The aim the present study was to verify this possibility. Methods: Urinary 8‐hydroxy‐2′‐deoxyguanosine (8‐OHdG), erythrocyte glutathione peroxidase (GSHPx) and superoxide dismutase (SOD), plasma concentrations selenium, zinc copper were measured until 100 days life in 30 infants mean ± SD birthweight gestational age...
Congenital Central Hypoventilation Syndrome (CCHS) is a rare disorder that impairs autonomic breathing control, leading to alveolar hypoventilation and sometimes central apnoea, predominantly during sleep. Patients typically require nocturnal ventilatory support alarms prevent life-threatening desaturation events. However, current alarm systems integrated into pulse oximeters do not provide adequate assistance at home. To address these limitations, we developed an assistive device with...
Abstract Oxidative stress is associated with several cardiovascular pathologies, including hypertension, cardiac hypertrophy and heart failure. Although oxidative also increased after ischaemia‐reperfusion (I/R), little known about the role activation mechanisms, in myocytes under these conditions, of NADPH oxidase, a superoxide‐producing enzyme. We found that rat muscle cells (H9c2) subjected to an vitro simulated ischaemia (substrate‐free medium plus hypoxia) followed by ‘reperfusion’,...
AbstractWe investigated the effect of 3-aminobenzamide (3-AB), an inhibitor nuclear enzyme poly(ADP-ribose) polymerase (PARP), against early ischemia/reperfusion (IR) injury in heart transplantation. In our experimental model, rat subjected to heterotopic transplantation, low temperature global ischemia (2 h) was followed by vivo reperfusion (60 min). these conditions, and absence 3-AB treatment, clear signs oxidative stress, such as lipid peroxidation, increase protein carbonyls DNA strand...
<h3>Objective:</h3> To compare transthoracic impedance (TTI/ECG) and pulse oximetry alarm traces detected during home monitoring in infants at risk of apnoea, bradycardia hypoxaemia. <h3>Study design:</h3> A retrospective evaluation the monitor downloads 67 who had undergone either TTI/ECG or using a device which can detect both parameters. <h3>Methods:</h3> The patients were categorised as: apparent life-threatening events (n = 39), preterm 21) miscellaneous 7). scored as true false alarms....
AbstractFree radicals and other reactive species generated during reperfusion of ischemic tissues may cause DNA damage and, consequently, the activation nuclear enzyme poly(ADP-ribose) polymerase (PARP). An excessive PARP result in a depletion intracellular NAD + ATP, hence cell suffering ultimately, death. The present study is aimed at clarifying role heart transplantation procedure contribution myocyte necrosis and/or apoptosis to this process. In our experimental model, rat subjected...
Despite the recent advances, clinical approach to persistent pulmonary hypertension of newborn (PPHN) still represents an important challenge for neonatologists. The care newborns with PPHN requires meticulous therapeutic and ventilation strategies including, besides stabilization newborn, use nitric oxide high-frequency ventilation. However, not all neonates PPHH are responsive this approach. Recent studies have proposed sildenafil, a phosphodiesterase 5 inhibitor, in refractory forms PPHN....
We evaluated the compliance of families using telemonitoring and conventional home monitoring in infants at risk apnoea, bradycardia hypoxaemia. Families who used telemedicine system could perform remote data transmission from their home. had to come regional centre download cardiorespiratory traces captured by monitor. A total 175 patients examined Regional Centre for Sudden Infant Death Syndrome (SIDS) Florence were included 5-year study. Good was defined as an average daily use 10 hours...
Congenital Central Hypoventilation Syndrome (CCHS) is a rare genetic disorder of the autonomic nervous system and in particular respiratory control during sleep. No drug therapy is, to date, available; therefore, survival these patients depends on lifelong ventilatory support Reactive oxygen species (ROS)-induced oxidative stress recognized risk factor involved pathogenesis several chronic diseases. Therefore, monitoring systemic could provide important insights into CCHS outcomes. Because...
Congenital Central Hypoventilation Syndrome (CCHS) is a rare disorder of the autonomic nervous system (ANS), characterized by inadequate control ventilation and global dysfunction. Heterozygous polyalanine repeat expansion mutations in exon 3 transcription factor Paired-like homeobox 2B (PHOX2B) gene occur 90% CCHS cases. In this study, we describe generation characterization two human induced pluripotent stem cell (hiPSC) lines from female patients carrying heterozygous + 5 alanine...
<b>Background:</b> Over recent years the improvement of non-invasive ventilation (NIV) use in pediatrics is also result availability more sophisticated materials and new specific pediatric mask interfaces. Selection assessment optimal interfaces currently relies on expertise knowledge those choosing mask. Respiratory physiotherapists (PTs) are increasingly involved NIV, contributing to its introduction proper selection interface. <b>Aims & Objectives:</b> The aim study is ...
Congenital central hypoventilation syndrome (CCHS) is a rare neurological genetic disorder that affects sleep-related respiratory control. Currently, no drug therapy available. In light of this, there need for lifelong ventilation support, at least during sleep, these patients. The pathogenesis several chronic diseases influenced by oxidative stress. Thus, determining stress in CCHS may indicate further disorders the course this disease. Liquid biopsies are widely used to assess circulating...
Abstract Background Patients who experience cardiorespiratory events usually have to be moved specialized centers perform studies. To avoid the transfer of these patients centers, a network has been created based on an interchange system, where recordings were uploaded in unspecialized (spokes) and downloaded by Sleep Disorders Breathing (SDB) Center (hub) analyzed. Methods The inter-hospital was established November 2008. Initially only 3 non-tertiary hospitals Tuscany Region joined...