- Optical Imaging and Spectroscopy Techniques
- Photoacoustic and Ultrasonic Imaging
- Infrared Thermography in Medicine
- Hemodynamic Monitoring and Therapy
- Optical Coherence Tomography Applications
- Non-Invasive Vital Sign Monitoring
- Functional Brain Connectivity Studies
- Spectroscopy Techniques in Biomedical and Chemical Research
- Voice and Speech Disorders
- Advanced Chemical Sensor Technologies
- Muscle Physiology and Disorders
- Glaucoma and retinal disorders
- Muscle activation and electromyography studies
- Physical Unclonable Functions (PUFs) and Hardware Security
- Graphene research and applications
- Infrared Target Detection Methodologies
- Advanced Fluorescence Microscopy Techniques
- Dental Erosion and Treatment
- Carbon Nanotubes in Composites
- Atherosclerosis and Cardiovascular Diseases
- Laser Applications in Dentistry and Medicine
- Electrical and Bioimpedance Tomography
- Neural dynamics and brain function
- Prosthetics and Rehabilitation Robotics
- Ocular Surface and Contact Lens
National Yang Ming Chiao Tung University
2012-2020
Institute of Biomedical Science
2019
National Taiwan University
2010-2012
National Yang Ming University Hospital
2012
National Tsing Hua University
2003
We characterized and imaged dental calculus using swept-source optical coherence tomography (SS-OCT). The refractive indices of enamel, dentin, cementum, were measured as 1.625 ± 0.024, 1.534 0.029, 1.570 0.021, 2.097 0.094, respectively. Dental leads strong scattering properties, thus, the region can be identified from enamel with SS-OCT imaging. An extracted human tooth is covered gingiva tissue an in vitro sample for tomographic
The prefrontal cortex (PFC) is thought to play an important role in "higher" brain functions such as personality and emotion that may associated with several gender-related mental disorders. In this study, the gender effects of functional connectivity, cortical lateralization significantly differences PFC were investigated by using resting-state optical tomography (fOT) measurement. A total forty subjects including twenty healthy male female adults recruited for study. results, hemoglobin...
Although Monte Carlo simulations of light propagation in full segmented three-dimensional MRI based anatomical models the human head have been reported many articles. To our knowledge, there is no patient-oriented simulation for individualized calibration with NIRS measurement. Thus, we offer an approach brain modeling on image segmentation process vivo T1 to investigate measurement simulation.In this study, modeled 3D as five layers structure. The behavior photon migration was studied...
The goal of this study is to prove that the light propagation in head by used 3-D optical model from vivo MRI data set can also provide significant characteristics on spatial sensitivity cerebral cortex folding geometry based Monte Carlo simulation. Thus, we proposed a approach for brain modeling near-infrared spectroscopy (NIRS). In results, profile and arrangement source-detector separation have being necessarily considered applications functional NIRS. optimal choice suggested within...
Radio frequency ablation (RFA) is a widely used alternative modality in the treatment of tumors. During RFA, temperature monitoring essential to ensure accurate and appropriate thermal dosage. Ultrasound imaging based on detection echo time-shift has been demonstrated have good ability monitor distribution. However, no study proven that region ultrasound can correspond well practical distribution tissue. In this study, we aim combine infrared systems clarify correlation between Five porcine...
Diffuse optical multipatch technique is used to assess spatial variations in absorption and scattering biological tissue, by monitoring changes the concentration of oxyhemoglobin deoxyhemoglobin. In our preliminary study, temporal tracings tissue oxygenation are measured using diffuse measurement a venous occlusion test, employing normal subjects ICU patients suffering from sepsis heart failure. experiments, obvious differences signals were observed among all three groups. This paper...
Abnormal prefrontal function plays a central role in the cognition deficits of schizophrenic patients; however, character relationship between discriminant analysis and activation remains undetermined. Recently, evidence low cortex (PFC) individuals with schizophrenia has also been found during verbal fluency tests (VFT) other cognitive several neuroimaging methods. The purpose this study is to assess hemodynamic changes PFC patients healthy controls VFT task by utilizing functional optical...
Harris corner detectors, which depend on strong invariance and a local autocorrelation function, display poor detection performance for infrared (IR) images with low contrast nonobvious edges. In addition, feature points detected by detectors are clustered due to the numerous nonlocal maxima. This paper proposes modified detector that includes two unique steps processing IR in order overcome aforementioned problems. Image enhancement based generalized form of histogram equalization (HE)...
Voice disorder such as vocal fatigue is a common and complex multifaceted clinical problem that presents significant impact on quality of life. In this study, the functional near-infrared diffuse optical technique (fNIRS-DOT) was proposed novel approach for human cords oxidative metabolism detection acoustic assessment simultaneously to provide multidimensional voice disorder. A totally 60 healthy subjects included 30 male female adults age-matched were recruited performed loading task...
For the first time, we proposed a 2T complementary architecture of one-time-programmable memory (OTP) in foundry logic CMOS chip. It was then used to realize PUF (Physical unclonable function), and combination with AI technology provide one-time password capability. At first, an OTP developed based on novel unit cell. The experimental results show that macro exhibits high speed operation, excellent data retention under more than 1 month baking at 200 <sup...
Duchenne muscular dystrophy (DMD) is an X-linked debilitating disease that may decrease nitric oxide (NO) production and lead to functional ischemia. Currently, the 6-minute walk test (6-MWT) North Star Ambulatory Assessment (NSAA) are primary outcome measures in clinical trials, but they severely limited by subjective consciousness mood of patients, can only be used older ambulatory boys. This study proposed using near-infrared spectroscopy (fNIRS) evaluate dynamic changes muscle...
Invasive Ductal Carcinoma (IDC) is one of the most frequently diagnosed breast cancers. IDC accounts for about 8 out 10 all invasive While early detection cancer essential reduction death rate, there may be already more than 7 cells in a when it can observed by X-ray mammogram. In contrast, passive IR spectrogram proposed Szu et al. was shown to promising detecting cancers several months ahead With energy readings from two cameras, middle wavelength (MIR, 3–5 μm) and long (LIR, 8–12 μm),...
The symptom of brain volumetric changes may provide significant biomarker to predict progressive dementia. prefrontal cortex are highly associated with many neurodegenerative diseases. Besides, atrophy reveals the expanded interhemispheric fissure and concomitant increasing cerebrospinal fluid volume. Thus, quantitative assessment is an important consideration for clinical studies In this study, we first proposed approach that uses near-infrared imaging detect changes. healthy, aged, typical...
This is the first study of dentin-enamel zone (DEZ) identification with tooth structure characterization based on optical Stokes-Mueller measurement. Stokes vectors a cross-sectional slice were measured using various polarization inputs. The direction DEZ different in enamel and dentin structures; therefore, profiles can specifically characterize structures DEZ. method, polarimetry, provides useful tool for characterizing tooth.
Abstract Near‐infrared spectroscopy (NIRS) is a noninvasive method for measuring the oxygenation in muscle and other tissues vivo . For quantitative NIRS measurement of dynamics, vessel‐occlusion test was usually applied as physiological intervention. There are several drawbacks that include skin contact, uncomfortable microcirculation block patients. Thus, we propose far‐infrared (FIR) illumination new intervention this paper. Our preliminary result shows linear correlation dynamic signals...
The presence of dental calculus is highly correlated with the formation and advancement periodontal disease.The occurrence relapse disease can be prevented only if completely removed.In this study, optical coherence tomography (OCT) used to obtain two-dimensional cross-sectional images tooth samples, in conjunction a segmentation technique that enables automatic identification calculus.We propose vertical intensity transform function correct nonuniform instrument signal caused by...
The activated leukocyte attacked the vascular endothelium and associated increase in VEcadherin number was observed experiments. confocal microscopic system with a prism-based wavelength filter used for multiwavelength fluorescence measurement. Multiwavelength imaging based on within aorta segment of rat achieved. capable detection cardiovascular tissue is useful tool measuring biological properties clinical applications.
This study proposed diffuser-aided diffuse optical imaging (DADOI) as a new approach to improve the performance of conventional tomography (DOT) for breast imaging. The 3-D model Monte Carlo simulation is remodeled from clinical MRI image. modified Beer-Lambert's law adopted with DADOI substitute complex algorithms inverse problem mapping spatial distribution, and depth information obtained based on time-of-flight estimation. results demonstrate that time-resolved method can be capable...
In this study, the dental calculus was characterized and imaged by means of swept-source optical coherence tomography (SSOCT). The refractive indices enamel, dentin, cementum were measured as 1.625±0.024, 1.534±0.029, 1.570±0.021 1.896±0.085, respectively. lead strong scattering property thus region can be identified under enamel with SSOCT imaging. An extracted human tooth covered gingiva tissue in vitro sample for
We present the first experimental results of time-resolved diffuser-aided diffuse optical imaging (DADOI) method in this paper. A self-manufactured diffuser plate was inserted between optode and surface a scattering medium. The utilized to enhance multiple that destroys image information for baseline measurement turbid Therefore, abnormality can be detected with modified density calculation. time-domain DADOI provide better contrast simpler than conventional tomography measurement. Besides,...
Verbal fluency tests (VFT) are widely used neuropsychological of frontal lobe and have been frequently in various functional brain mapping studies. There two versions VFT based on the type cue: letter task (LFT) category (CFT). However, fundamental aspect connectivity across spatial regions fronto-temporal during VFTs has not elucidated to date. In this study we hypothesized that different cortical over bilateral can be observed by means multi-channel fNIRS LFT CFT respectively. Our results...