A5005801391- Neurobiology of Language and Bilingualism
- EEG and Brain-Computer Interfaces
- Speech and Audio Processing
- Speech Recognition and Synthesis
- Language Development and Disorders
- Neural dynamics and brain function
- Neurological disorders and treatments
- Advanced Neuroimaging Techniques and Applications
- Advanced MRI Techniques and Applications
- Neuroscience and Neural Engineering
- Functional Brain Connectivity Studies
- Bacterial Infections and Vaccines
- Motor Control and Adaptation
- Radiation Dose and Imaging
- Blind Source Separation Techniques
- Neuroscience and Neuropharmacology Research
- Reading and Literacy Development
- Head and Neck Surgical Oncology
- Multisensory perception and integration
- Glycogen Storage Diseases and Myoclonus
- Epilepsy research and treatment
- Electrochemical Analysis and Applications
- Neuroinflammation and Neurodegeneration Mechanisms
- Neonatal and fetal brain pathology
- Phonetics and Phonology Research
University of California, San Francisco
2021-2025
University of California, Berkeley
2022-2025
Neurological Surgery
2022-2025
Neurosciences Institute
2023
University of Pennsylvania
2019-2022
National Institute of Neurological Disorders and Stroke
2019
National Institutes of Health
2019
Brain maps, or atlases, are essential tools for studying brain function and organization. The abundance of available atlases used across the neuroscience literature, however, creates an implicit challenge that may alter hypotheses predictions we make about neurological pathophysiology. Here, demonstrate how parcellation scale, shape, anatomical coverage, other atlas features impact our prediction brain's from its underlying structure. We show network topology, structure-function correlation...
Speech perception and production are interconnected processes, but the underlying neural mechanisms remain unclear. We investigated this relationship by recording large-scale single-neuron activity in human brain during a delayed sentence repetition task. Contrary to traditional view that precentral gyrus is solely responsible for motor execution, we found neurons there encoded across all task phases of listening, delay, initiation, speaking. Notably, discovered "mirror" activated...
Neuroprostheses can restore communicative ability to people with paralysis by decoding intended speech movements from the sensorimotor cortex (SMC). However, overlapping neural populations in SMC are also engaged visual and auditory processing. The nature of these shared motor perceptual activations their potential interfere particularly relevant questions for neuroprostheses, as reading listening essential daily functions. In two participants vocal-tract anarthria (ClinicalTrials.gov;...
Numerous formulations of nanoparticle-based X-ray computed tomography (CT) contrast agents made heavy metal elements are under investigation for their ability to provide improved CT imaging. Thus far, most experimental have been developed with atoms a single element. However, inspired by the composites formed from multiple used in radioprotective garments, we hypothesized that several whose K-edge energies spaced out high photon flux region could achieve high, broadband attenuation across...
Implanted neurostimulation devices are gaining traction as palliative treatment options for certain forms of drug-resistant epilepsy, but clinical utility these is hindered by incomplete mechanistic understanding their therapeutic effects. Approved anterior thalamic nuclei deep brain stimulation (ANT DBS) thought to work at a network level, limited sensing capability precludes characterization neurophysiological effects outside the thalamus. Here, we describe patient with temporal lobe...
Cognitive impairment often impacts quality of life in epilepsy even if seizures are controlled. Word-finding difficulty is particularly prevalent and attributed to etiological (static, baseline) circuit alterations. We sought determine whether interictal discharges convey significant superimposed contributions word-finding patients, so, through which cognitive mechanism(s).
White matter supports critical brain functions such as learning and memory, modulates the distribution of action potentials, transmits neural information between regions. Notably, neuronal cell bodies exist in deeper white tissue, neurotransmitter vesicles are released directly matter, blood-oxygenation level dependent (BOLD) signals detectable across a range different tasks—all appearing to reflect dynamic, active tissue from which recorded can reveal meaningful about brain. Yet, within...
BACKGROUND Apraxia of speech is a disorder speech-motor planning in which articulation effortful and error-prone despite normal strength the articulators. Phonological alexia agraphia are disorders reading writing disproportionately affecting unfamiliar words. These almost always accompanied by aphasia. OBSERVATIONS A 36-year-old woman underwent resection grade IV astrocytoma based left middle precentral gyrus, including cortical site associated with arrest during electrocortical stimulation...
OBJECTIVE The objectives of this study were to describe the authors’ clinical methodology and outcomes for mapping laryngeal motor cortex (LMC) define localization LMC in a cohort neurosurgical patients undergoing intraoperative brain mapping. Because variability across patients, authors aimed probabilistic distribution cortical sites that evoke movement, as well adjacent somatotopic representations face (mouth), tongue, hand. METHODS Thirty-six underwent left (n = 18) or right craniotomy...
Abstract Natural speech is full of starts and stops. Here, we studied the neural mechanisms that underlie inhibitory control speech, specifically ability to stop speaking on demand. We recorded direct cortical activity while participants made continuous production were given a visual cue speaking. Neural recordings revealed in premotor frontal cortex associated with stopping. Cortical sites showing largely distinct from involved active or, more specifically, encoding articulatory movements....
Brain maps, or atlases, are essential tools for studying brain function and organization. The abundance of available atlases used across the neuroscience literature, however, creates an implicit challenge that may alter hypotheses predictions we make about neurological pathophysiology. Here, demonstrate how parcellation scale, shape, anatomical coverage, other atlas features impact our prediction brain’s from its underlying structure. We show network topology, structure-function correlation...