A5031954827- Functional Brain Connectivity Studies
- EEG and Brain-Computer Interfaces
- Advanced MRI Techniques and Applications
- Neurobiology of Language and Bilingualism
- Neural dynamics and brain function
- Alzheimer's disease research and treatments
- Dementia and Cognitive Impairment Research
- Epilepsy research and treatment
- Neurological disorders and treatments
- Advanced Neuroimaging Techniques and Applications
- Advanced Causal Inference Techniques
- Language Development and Disorders
- Cardiovascular and Diving-Related Complications
- Acute Ischemic Stroke Management
- Reading and Literacy Development
- Neuroscience and Neural Engineering
- Sleep and Wakefulness Research
- Sleep and related disorders
University of California, San Francisco
2018-2024
Neurological Surgery
2019-2024
University of Pennsylvania
2024
Oxford University Press (United Kingdom)
2020
Mallinckrodt (United States)
2018
University of Illinois Urbana-Champaign
2015
Amyloid imaging is a valuable tool for research and diagnosis in dementing disorders. Successful use of this limited by the lack common standard quantification amyloid data. The Centiloid approach was recently proposed to address problem work, we report our implementation evaluate impact differences underlying image analysis methodologies using both cross-sectional longitudinal datasets. successfully converts quantitative burden measurements into scale (CL) comparable dynamic range. As...
Quantitative in vivo measurement of brain amyloid burden is important for both research and clinical purposes. However, the existence multiple imaging tracers presents challenges to interpretation such measurements. This study a direct comparison Pittsburgh compound B-based florbetapir-based same participants from two independent cohorts using crossover design.Pittsburgh B florbetapir PET data three different were analyzed previously established pipelines obtain global These measurements...
Functional magnetic resonance imaging (fMRI) is an important tool for pre-surgical evaluation of eloquent cortex. Classic task-based paradigms require patient participation and individual sequence acquisitions each functional domain that being assessed. Resting state fMRI (rs-fMRI), however, enables localization without can evaluate numerous domains with a single session. To date, post-processing this resting data has been resource intensive, which limits its widespread application routine...
Broca's aphasia is a syndrome of impaired fluency with retained comprehension. The authors used an unbiased algorithm to examine which neuroanatomical areas are most likely result in following surgical lesions.
Implanted neurostimulation devices are gaining traction as palliative treatment options for certain forms of drug-resistant epilepsy, but clinical utility these is hindered by incomplete mechanistic understanding their therapeutic effects. Approved anterior thalamic nuclei deep brain stimulation (ANT DBS) thought to work at a network level, limited sensing capability precludes characterization neurophysiological effects outside the thalamus. Here, we describe patient with temporal lobe...
OBJECTIVE Recent trends have moved from subdural grid electrocorticography (ECoG) recordings toward stereo-electroencephalography (SEEG) depth electrodes for intracranial localization of seizures, in part because perceived morbidity and strip electrodes. For invasive epilepsy monitoring, the authors describe outcomes a hybrid approach, whereby patients receive combination grids, strips, frameless stereotactic electrode implantations through craniotomy. Evolution surgical techniques was...
Treatment-resistant depression is a leading cause of disability. Our center's trial for neurosurgical intervention treatment-resistant involves staged workup implantation personalized, closed-loop neuromodulation device refractory depression. The first stage ("stage 1") 10 stereoelectroencephalography (SEEG) electrodes bilaterally into 5 anatomically defined brain regions and specialized preoperative imaging planning frame-based operating protocol.
Summary Objective Intracranial electroencephalography (ICEEG) recordings are performed for seizure localization in medically refractory epilepsy. Signal quantifications such as frequency power can be projected heatmaps on personalized three‐dimensional (3D) reconstructed cortical surfaces to distill these complex into intuitive cinematic visualizations. However, simultaneously reconciling deep recording locations and reliably tracking evolving ictal patterns remain significant challenges....
INTRODUCTION: Why do similar neurosurgical lesions cause a range of deficits in speech production? We investigated Broca’s aphasia as disorder fluency and apraxia (AOS) articulatory coordination to dissociate the anatomy lesional etiology these syndromes. METHODS: Patients were prospectively tested with standardized paradigm. Resections outlined into 3D regions interest transformed common brainspace (MNI brain). Recordings retrospectively review by language experts assess speech. A...
BackgroundHumans routinely shift their sleepiness and wakefulness levels in response to emotional factors. The diversity of factors that modulates sleep-wake suggests the ascending arousal network may be intimately linked with networks mediate mood. Indeed, while animal studies have identified select limbic structures play a role regulation, breadth corticolimbic directly humans remains unknown.ObjectiveWe investigated whether regional activation through direct electrical stimulation can...
Purpose: In the quantification of functional neuroimaging data, region‐of‐interest (ROI) analysis can be used to assess a variety properties activation signal, but taken alone these are susceptible noise and may fail accurately describe overall regional involvement. Here, authors present evaluate an automated method for localization data that combines multiple signal generate rank‐order lists results. Methods: The proposed method, referred as results decomposition (NIRD), begins by...
Abstract Brodmann’s areas 44/45 of the inferior frontal gyrus (IFG), are seat Broca’s area. The Western Aphasia Battery is a commonly used language battery that diagnoses aphasias based on fluency, comprehension, naming and repetition. aphasia defined as low fluency (0-4/10), retained comprehension (4-10/10), variable deficits in repetition (0-7.9/10) (0-8/10). purpose this study was to find anatomic associated with aphasia. Patients who underwent resective brain surgery dominant hemisphere...
Lee, Anthony T; Nichols, Noah M.L BS; Speidel, Benjamin; Fan, Joline; Knowlton, Robert C MD; Chang, Edward F MD Author Information